2011
DOI: 10.1590/s0100-879x2011007500011
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Increased expression of keratinase and other peptidases by Candida parapsilosis mutants

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Cited by 23 publications
(12 citation statements)
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“…The first was the use of 1-methyl-3-nitro-1-nitrosoguanidine for the treatment of Bacillus subtilis KD1, that produced a mutant with a keratinolytic activity double that of the wild type (Cai et al 2008). The second one was the use of EMS to mutate Candida parapsilosis, which produced three mutants presenting 1.4-, 1.5-and 1.7fold activity of the wild type (Duarte et al 2011). Looking at the proportion of increase of protein expression, the results of this work are similar to those obtained in the two works mentioned above.…”
Section: Discussionsupporting
confidence: 77%
See 1 more Smart Citation
“…The first was the use of 1-methyl-3-nitro-1-nitrosoguanidine for the treatment of Bacillus subtilis KD1, that produced a mutant with a keratinolytic activity double that of the wild type (Cai et al 2008). The second one was the use of EMS to mutate Candida parapsilosis, which produced three mutants presenting 1.4-, 1.5-and 1.7fold activity of the wild type (Duarte et al 2011). Looking at the proportion of increase of protein expression, the results of this work are similar to those obtained in the two works mentioned above.…”
Section: Discussionsupporting
confidence: 77%
“…Thus, keratinous materials can remain inert in the environment for a long time, as keratinase producing microorganisms are not widespread (Lange et al 2016). However, despite their rigid structure, keratins are recycled in nature and can be efficiently degraded by a few microorganisms such as bacteria from the genus Bacillus (Fellahi et al 2016), Streptomyces (Ramakrishnan et al 2011) from several species of fungi (El-Gendy 2010; Duarte et al 2011;Bohacz 2017) and from Archaea (Kublanov et al 2009;Brandelli et al 2010) that are capable of producing keratinolytic peptidases known as keratinases.…”
Section: Introductionmentioning
confidence: 99%
“…Temperature (A), and pH (B). The enzymatic extract was obtained after growth in medium F with 1% feather at pH 8.0 been observed for other microorganisms such as Candida parapsilosis and other bacillus strains isolated from industrial waste (Williams et al 1990;Kim et al 2001;Rozs et al 2001;Duarte et al 2011).…”
Section: Discussionmentioning
confidence: 99%
“…9 Despite known differences in virulence, it is unclear what virulence factors (biofilm development, lipases, or aspartyl proteinases) may play a role in the final outcome. [10][11][12][13][14][15] Murine models are the gold standard for virulence studies; however, ethical considerations associated with mammalian models have made invertebrate models (Caenorhabditis elegans, Drosophila melanogaster, Galleria mellonella, Dictyostelium discoideum, etc.) an attractive alternative.…”
Section: Introductionmentioning
confidence: 99%