Increased expression of interleukin-1α and interleukin-1β is associated with experimental varicocele

Sahin, Zeliha; Çelik-Özenci, Çiler; Akkoyunlu, Gökhan; Korgun, Emin Türkay; Acar, Nuray; Erdoğru, Ti̇bet; Demir, Ramazan; Üstünel, İ̇smail

doi:10.1016/j.fertnstert.2005.10.025

Cited by 36 publications

(26 citation statements)

References 23 publications

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“…Both IL‐1α and IL‐1β are known as inflammatory mediators, which regulate critical physiological functions in the testis (Sahin et al, ). IL‐1α is involved in spermatogenesis promotion and steroidogenesis regulation (Guazzone et al, ), and IL‐1β has a role in the damage of testicular tissues (Bergh & Soder, ).…”

Section: Discussionmentioning

confidence: 99%

Alteration of testicular regulatory and functional molecules following long‐time exposure to 900 MHz RFW emitted from BTS

Azimzadeh

Jelodar

2019

Andrologia

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The aim of this investigation was to evaluate changes in testosterone and some of the functional and regulatory molecules of testis such as P450scc, steroidogenic acute regulatory protein (StAR), tumour necrosis factor-α (TNF-α), interleukin-1α (IL-1α), interleukin-1β (IL-1β) and nerve growth factor (NGF) following exposure to 900 MHz radio frequency (RF). Thirty adult male Sprague Dawley rats (190 ± 20 g BW) were randomly classified in three equal groups, control (sham, without any exposure), short-time exposure (2 hr) (STE) and long-time exposure (4 hr) (LTE). The exposure was performed for 30 consecutive days. The testosterone level in both exposed groups was significantly less than control (p < .05). Level of TNF-α in both exposed groups was significantly greater than control (p < .05). IL-1α and NGF levels in LTE were significantly higher than the STE and control groups (p < .05). Level of IL-1β in LTE was significantly higher than control (p < .05). Expression of both P450scc and StAR mRNA was significantly down-regulated in both exposed groups compared to control (p < .05). Our results showed that RFW can affect testis and reproductive function through changes in factors, which are important during steroidogenesis, and also through changes in inflammatory factors, which regulate Leydig cell functions. K E Y W O R D S900 MHz radio frequency, cytokine, P450scc, StAR, testosterone

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Section: Discussionmentioning

confidence: 99%

Alteration of testicular regulatory and functional molecules following long‐time exposure to 900 MHz RFW emitted from BTS

Azimzadeh

Jelodar

2019

Andrologia

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“…Sahin et al . reported increased IL‐1α expression in Leydig cells, Sertoli cells and spermatogonia of adolescent rats with ELV, and proposed that IL‐1α might affect both germ‐cell and immature Leydig‐cell proliferation, and modulate adult Leydig‐ and Settle‐cell function 66 . IL‐1 produces free radicals in many tissues, showing that increased IL‐1α expression in testes with varicocele indirectly causes sperm dysfunction through oxidative stress.…”

Section: Other Mechanismsmentioning

confidence: 99%

Pathophysiology of varicocele in male infertility in the era of assisted reproductive technology

2012

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Abbreviations & Acronyms 4-HNE = 4-hydroxy-2-nonenal 8-OHdG = 8-hydroxy-2′-deoxyguanosine ART = assisted reproductive technology CCM = cerebral cavernous malformation CREM = cyclic adenosine 3′,5′-monophosphate response element modulator ELV = experimental left varicocele eNOS = endothelial nitric oxide synthase GDNFa1 = glial cell line-derived neurotropic factor receptor a1 GSR = glutathione reductase GPX = glutathione peroxidase GST = glutathione S-transferase HIF1 = hypoxia-inducible factor 1 HO-1 = heme oxygenase 1 ICSI = intracytoplasmic sperm injection IL-1 = interleukin-1 iNOS = inducible nitric oxide synthase IUI = intrauterine insemination IVF = in vitro fertilization MDA = malondialdehyde nNOS = neuronal nitric oxide synthase NO = nitric oxide PDRN = polydeoxyribonucleotide PCNA = proliferating cell nuclear antigen PN = pronuclear O2 -= superoxide anion ROS = reactive oxygen species RNS = reactive nitrogen species SOD = superoxide dismutase TUNEL = terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling VEGF = vascular endothelial growth factor Abstract: Varicocele is the most common and treatable cause of male infertility. Studies of a rat experimental left varicocele model and human testicular biopsy samples have shown the involvement of various factors in its pathophysiology. Among them, oxidative stress plays a major role in impairing spermatogenesis and sperm function. Therefore, in addition to palpation, scrotal ultrasonography and color Doppler ultrasound , evaluation of testicular oxidative stress (e.g. scrotal temperature is a surrogate parameter) is recommended to enable diagnosis and suitable treatment of varicocele. Varicocelectomy increases the fertilization, pregnancy and live birth rates, indicating improved sperm function; it is therefore important even in couples undergoing intracytoplasmic sperm injection. Routine sperm-function tests are warranted to monitor the sperm quality after varicocelectomy and consequent improvement in the outcomes of assisted reproductive technology. Furthermore, the indications of varicocelectomy in assisted reproductive technology should be widened.Key words: assisted reproductive technologies, oxidative stress, varicocele. Role of sperm factors in ICSIVaricocele is the most common cause of male infertility. Its prevalence is notably high (~40%) in couples with male factor infertility compared with the general population (Յ20%).1 While debating the pathophysiology of varicocele, its influence on infertility treatment should be considered. Twenty years ago, we reviewed that varicocele causes spermatogenic disorder, and attempted to detect and treat as many cases as possible. 2 In the 1990s, the widespread application of ICSI lowered the importance of varicocele treatment. Furthermore, the usefulness of varicocele treatment itself was regarded as doubtful. 3,4 In contrast, two recent meta-analyses have shown that varicocelectomy significantly improves sperm concentration and motility in infertile men with palpable varicocel...

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“…During genital tract inflammation or cellular immunity against microbial antigens, activated leucocytes in human seminal fluid are able to release elastase (PMN elastase), cathepsin G, collagenase‚ reactive oxygen species (ROS), inflammatory and anti‐inflammatory cytokines (Makker, Agarwal, & Sharma, ). Some investigations have suggested that varicocele‐related infertility is also associated with cytokines (Fraczek & Kurpisz, ; Hakimi et al., ; Matalliotakis et al., ; Sahin et al., ). Additionally, various immunocompetent cells are capable to release cytokines in the male urogenital tract (Kocak, Yenisey, Dündar, Okyay, & Serter, ).…”

Section: Introductionmentioning

confidence: 99%

Inflammatory and anti-inflammatory cytokines in the seminal plasma of infertile men suffering from varicocele

et al. 2016

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Varicocele is one of causes of the declined sperm quality and low sperm production, which can lead to infertility in males. There are several experimental and epidemiological findings which support the idea that inflammatory mechanisms play an essential role in varicocele pathogenesis. Besides, in this pathological state, interleukin-37 (IL-37) as an anti-inflammatory cytokine is able to bind interleukin-18-binding protein (IL-18BP), and subsequently binds IL-18 receptor β, inhibiting the pro-inflammatory activity of IL-18. To explore the interaction between IL-37 and IL-18 in infertility, we measured the amount of these cytokines in the seminal fluid of infertile men affected by varicocele. The seminal plasma levels of IL-37 and IL-18 were measured in 75 infertile men with varicocele and 75 healthy fertile controls (age range, 30-48 years) using enzyme-linked immunosorbent assay. The seminal levels of IL-37 and IL-18 were significantly increased in infertile men with varicocele when compared to fertile controls (p < .0001). Because of the essential role(s) of cytokines in inflammatory response of cell systems, it could be possible that sperm motility is reduced following increased IL-18, activated neutrophils and reactive oxygen species in semen of infertile patients with varicocele. Moreover, the results of this study indicated that interaction between IL-37 and IL-18Rβ can lead to reduced inflammatory responses. It seems that IL-37 might be a potential biomarker and therapeutic target for male infertility.

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Increased expression of interleukin-1α and interleukin-1β is associated with experimental varicocele

Cited by 36 publications

References 23 publications

Alteration of testicular regulatory and functional molecules following long‐time exposure to 900 MHz RFW emitted from BTS

Alteration of testicular regulatory and functional molecules following long‐time exposure to 900 MHz RFW emitted from BTS

Pathophysiology of varicocele in male infertility in the era of assisted reproductive technology

Inflammatory and anti-inflammatory cytokines in the seminal plasma of infertile men suffering from varicocele

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