Increased Expression of Inflammatory Cytokines and Discogenic Neck Pain

Kang, Xinjian; Qian, Man; Qin, Tao; Liu, Mingli; Xu, Haiwei; Xu, Baoshan

doi:10.1111/os.13963

Cited by 5 publications

(3 citation statements)

References 26 publications

(81 reference statements)

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“… 10 , 36 Besides, interleukin 1A (IL‐1A) and matrix metalloproteinase 3 (MMP‐3) were also proved to be significantly associated with type 2 MC. 29 , 37 , 38 , 39 …”

Section: Discussionmentioning

confidence: 99%

Clinical and Radiological Outcomes of Cervical Disc Arthroplasty in Patients with Modic Change

Deng,

Sheng,

Wang

et al. 2024

Orthopaedic Surgery

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ObjectiveModic change (MC) is defined as abnormalities observed in the intervertebral disc subchondral and adjacent vertebral endplate subchondral bone changes. Most studies on MC were reported in the lumbar spine and associated with lower back pain. However, MC has been rarely reported in the cervical spine, let alone in those who underwent cervical disc replacement (CDR). This study aimed to focus on MC in the cervical spine and reveal clinical and radiological parameters, especially heterotopic ossification (HO), for patients who underwent CDR. Furthermore, we illustrated the association between MC and HO.MethodsWe retrospectively reviewed patients who underwent CDA from January 2008 to December 2019. The Japanese Orthopaedic Association (JOA), Neck Disability Index (NDI), and Visual Analog Scale (VAS) scores were used to evaluate the clinical outcomes. Radiological evaluations were used to conclude the cervical alignment (CL) and range of motion (ROM) of C2‐7, functional spinal unit angle (FSUA), shell angle (SA), FSU height, and HO. Univariate and multivariate logistic regressions were performed to identify the risk factors for HO. The Kaplan–Meier (K‐M) method was used to analyze potential risk factors, and multivariate Cox regression was used to identify independent risk factors.ResultsA total of 139 patients were evaluated, with a mean follow‐up time of 46.53 ± 26.60 months. Forty‐nine patients were assigned to the MC group and 90 to the non‐MC group. The incidence of MC was 35.3%, with type 2 being the most common. Clinical outcomes (JOA, NDI, VAS) showed no significant difference between the two groups. The differences in C2‐7 ROM between the two groups were not significant, while the differences in SA ROM and FSUA ROM were significantly higher in the non‐MC than in the MC group (p < 0.05). Besides, FSU height in MC group was significantly lower than that in non‐MC group. Parameters concerning CL, including C2‐7, FSUA, SA, were not significantly different between the two groups. The incidence of HO and high‐grade HO, respectively, in the MC group was 83.7% and 30.6%, while that in the non‐MC group was 53.3% and 2.2%, and such differences were significant (p < 0.05). Multivariate logistic regression analyses and Cox regression showed that MC and involved level were significantly associated with HO occurrence (p < 0.05). No implant migration and secondary surgery were observed.ConclusionMC mainly affected the incidence of HO. Preoperative MC was significantly associated with HO formation after CDR and should be identified as a potential risk factor for HO. Rigorous criteria for MC should be taken into consideration when selecting appropriate candidates for CDR.

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“… 10 , 36 Besides, interleukin 1A (IL‐1A) and matrix metalloproteinase 3 (MMP‐3) were also proved to be significantly associated with type 2 MC. 29 , 37 , 38 , 39 …”

Section: Discussionmentioning

confidence: 99%

Clinical and Radiological Outcomes of Cervical Disc Arthroplasty in Patients with Modic Change

Deng,

Sheng,

Wang

et al. 2024

Orthopaedic Surgery

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“…Abnormal muscle activities and bodily posture may be employed for compensation, thereby contributing to poor postoperative efficacy. (2) Aseptic inflammation may occur, given that recent investigations have elucidated [ 38 ] that inflammatory cytokines are overexpressed within the cervical disc. This inflammatory state elicits a variety of pathogenic responses, including cellular senescence, apoptosis, inward proliferation of nerves and blood vessels, and discogenic pain, potentially impeding the recovery of neurological function in patients.…”

Section: Discussionmentioning

confidence: 99%

Risk factors for poor neurological recovery after anterior cervical discectomy and fusion: imaging characteristics

Lu,

Zhang,

Chai

et al. 2024

J Orthop Surg Res

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Background Poor neurological recovery in patients after anterior cervical discectomy and fusion has been frequently reported; however, no study has analyzed the preoperative imaging characteristics of patients to investigate the factors affecting surgical prognosis. The purpose of this study was to investigate the factors that affect the preoperative imaging characteristics of patients and their influence on poor neurologic recovery after anterior cervical discectomy and fusion. Methods We retrospectively analyzed the clinical data of 89 patients who met the criteria for anterior cervical discectomy and fusion for the treatment of single-level cervical spondylotic myelopathy and evaluated the patients’ neurological recovery based on the recovery rate of the Japanese Orthopaedic Association (JOA) scores at the time of the final follow-up visit. Patients were categorized into the “good” and “poor” groups based on the JOA recovery rates of ≥ 50% and < 50%, respectively. Clinical information (age, gender, body mass index, duration of symptoms, preoperative JOA score, and JOA score at the final follow-up) and imaging characteristics (cervical kyphosis, cervical instability, ossification of the posterior longitudinal ligament (OPLL), calcification of herniated intervertebral discs, increased signal intensity (ISI) of the spinal cord on T2-weighted imaging (T2WI), and degree of degeneration of the discs adjacent to the fused levels (cranial and caudal) were collected from the patients. Univariate and binary logistic regression analyses were performed to identify risk factors for poor neurologic recovery. Results The mean age of the patients was 52.56 ± 11.18 years, and the mean follow-up was 26.89 ± 11.14 months. Twenty patients (22.5%) had poor neurological recovery. Univariate analysis showed that significant predictors of poor neurological recovery were age (p = 0.019), concomitant OPLL (p = 0.019), concomitant calcification of herniated intervertebral discs (p = 0.019), ISI of the spinal cord on T2WI (p <0.05), a high grade of degeneration of the discs of the cranial neighboring levels (p <0.05), and a high grade of discs of the caudal neighboring levels (p <0.05). Binary logistic regression analysis showed that ISI of the spinal cord on T2WI (p = 0.001 OR = 24.947) and high degree of degeneration of adjacent discs on the cranial side (p = 0.040 OR = 6.260) were independent risk factors for poor neurological prognosis. Conclusion ISI of the spinal cord on T2WI and high degree of cranial adjacent disc degeneration are independent risk factors for poor neurological recovery after anterior cervical discectomy and fusion. A comprehensive analysis of the patients’ preoperative imaging characteristics can help in the development of surgical protocols and the management of patients’ surgical expectations.

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“…IL-1β and TNF-α were selected in the present Gels 2024, 10, 396 7 of 13 study because they are cytokines involved in the high pathways of the inflammatory process. Both cytokines have been implicated as key mediators in chronic musculoskeletal degenerative/inflammatory diseases such as osteoarthritis, teno-desmopathies, and spondylopathies, among others [34][35][36]. 3 and 4.…”

Section: Glmm Numbermentioning

confidence: 99%

Short-Term Effects of Two COX-2 Selective Non-Steroidal Anti-Inflammatory Drugs on the Release of Growth Factors and Cytokines from Canine Platelet-Rich Gel Supernatants

Ospina,

Carmona,

López

2024

Gels

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(1) Background: There is a lack of knowledge about how a single dose of COX-2 selective non-steroidal anti-inflammatory drugs (NSAIDs) might affect the release of growth factors (GFs) and cytokines from canine platelet-rich gels (PRGs) and other hemocomponents. (2) Methods: A crossover study was conducted in six adult mongrel dogs. Animals were randomized to receive a single dose of either carprofen or firocoxib. PRG, temperature-induced platelet lysate (TIPL), chemically induced PL (CIPL), and plasma hemocomponents were obtained from each dog before (1 h) and after (6 h) the treatments. Platelet and leukocyte counts and determination of the concentrations of platelet-derived growth factor-BB, (PDGF-BB), transforming growth factor beta-1 (TGF-β1), interleukin 1 beta (IL-1β), tumor necrosis factor-alpha (TNF-α) and IL-10 concentrations were assayed by ELISA in all hemocomponents. (3) Results: Both platelet and leukocyte counts and PDGF-BB concentrations were not affected by NSAIDs and time. Total TGF-β1 concentrations were not affected by NSAIDs; however, the release of this GF was increased in PRG supernatants (PRGS) at 6 h. IL-1β and TNF-α concentrations were significantly (p < 0.001) lower in both firocoxib PRGS and plasma at 6 h, respectively. IL-10 concentrations were significantly (p < 0.001) lower at 6 h in all hemocomponents treated with both NSAIDs. (4) Conclusions: The clinical implications of our findings could indicate that these drugs should be withdrawn from patients to allow their clearance before the clinical use of PRP/PRG. On the other hand, the prophylactic use of NSAIDs to avoid the inflammatory reactions that some patients might have after PRP/PRG treatment should be performed only in those animals with severe reactive inflammation to the treatment.

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Increased Expression of Inflammatory Cytokines and Discogenic Neck Pain

Cited by 5 publications

References 26 publications

Clinical and Radiological Outcomes of Cervical Disc Arthroplasty in Patients with Modic Change

Clinical and Radiological Outcomes of Cervical Disc Arthroplasty in Patients with Modic Change

Risk factors for poor neurological recovery after anterior cervical discectomy and fusion: imaging characteristics

Short-Term Effects of Two COX-2 Selective Non-Steroidal Anti-Inflammatory Drugs on the Release of Growth Factors and Cytokines from Canine Platelet-Rich Gel Supernatants

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