Increased expression of heat shock protein 70 and heat shock factor 1 in chronic dermal ulcer tissues treated with laser-aided therapy

Zhou, Jianda; Cheng-qun, Luo; Xie, Hui; Nie, Xinmin; Zhao, Yanzhong; Wang, Shaohua; Xu, Yi; Pokharel, Pashupati Babu; Xu, Dan

doi:10.1097/00029330-200807020-00004

Cited by 21 publications

(21 citation statements)

References 7 publications

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“…As a result, yHSF is essential for viability, paralleling the importance of HSF1 for the survival and proliferation of cancer cells (Dai et al, 2007). Activation of HSF1 may also be required in animals in states of high proliferation and altered metabolism such as immune activation and wound healing (Rokavec et al, 2012; Xiao et al, 1999; Zhou et al, 2008). Moreover, in diverse eukaryotes, HSF is a well-validated longevity factor; non-classical activation of this transcription factor could be highly relevant in this context (Chiang et al, 2012; Volovik et al, 2012)…”

Section: Discussionmentioning

confidence: 99%

HSF1 Drives a Transcriptional Program Distinct from Heat Shock to Support Highly Malignant Human Cancers

Mendillo

Santagata

Koeva

et al. 2012

Cell

619

858

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SUMMARY Heat-Shock Factor 1 (HSF1), master regulator of the heat-shock response, facilitates malignant transformation, cancer cell survival and proliferation in model systems. The common assumption is that these effects are mediated through regulation of heat-shock protein (HSP) expression. However, the transcriptional network that HSF1 coordinates directly in malignancy and its relationship to the heat-shock response have never been defined. By comparing cells with high and low malignant potential alongside their non-transformed counterparts, we identify an HSF1-regulated transcriptional program specific to highly malignant cells and distinct from heat shock. Cancer-specific genes in this program support oncogenic processes: cell-cycle regulation, signaling, metabolism, adhesion and translation. HSP genes are integral to this program, however, many are uniquely regulated in malignancy. This HSF1 cancer program is active in breast, colon and lung tumors isolated directly from human patients and is strongly associated with metastasis and death. Thus, HSF1 rewires the transcriptome in tumorigenesis, with prognostic and therapeutic implications.

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Section: Discussionmentioning

confidence: 99%

HSF1 Drives a Transcriptional Program Distinct from Heat Shock to Support Highly Malignant Human Cancers

Mendillo

Santagata

Koeva

et al. 2012

Cell

619

858

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“…LLLT, as a noninvasive, pain-free method with minor side effects, has been considered as a possible treatment option for diabetic foot syndrome. There is not yet a unique explanation of the mode of functioning of laser therapy in the treatment of diabetic ulcers 13 . Biometrical and histological analysis indicated "faster lesion contraction showing quicker reepithelization and reformed connective tissue with more organized collagen fibers" in irradiated wounds 14 .…”

Section: Bacterial Growth and Lllt Observationmentioning

confidence: 99%

Effect of Low-Level Laser Therapy on Diabetic Foot Ulcers

Kailashdan¹,

Arjunbhai²

2019

IJMBS

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Background: Across the globe, diabetes mellitus (DM) is considered as a major health issue because of its prevalence rate tending to increase day by day in a remarkable manner. A foot ulcer is frequently faced complication that is very frequently faced in patients suffering from diabetes mellitus. Diabetic Mellitus is noticed as a severe health issue affecting around 387 million people. The purpose of this study is to study the effect of low level laser therapy on diabetic foot ulcers to control infection, determine best suitable cost-effective technique and aid in studying the role of Low-level laser therapy in the context of treating diabetic foot ulcers. Aim: To study the role of low-level laser therapy on diabetic ulcers Results: The proportion of males was slightly higher than females in both cases and controls. The mean BMI was 26.50±2.444 among cases and mean BMI was 25.27±2.407 among controls. Among 16 grades 1 ulcer, 6 (37.5%) remained in grade 1, 10 (62.5%) ulcers completely healed at the end of 20 days. In group B, 21 subjects had bacterial growth on day-1, and the remaining 19 had no bacterial growth. Out of the 21 with bacterial growth, 15(71.42%) still had growth at the end of 20 days, and 6 (28.58%) had no growth. Methods: The current study was a randomized open labelled control study, with randomised two treatment groups [Group A: Intervention group (who received laser therapy in addition to standard management) Group B: Control group (standard treatment group)] and total sample size of 80 performed at the Department of Surgery, Banas Medical College and Research Institute, Palanpur, Gujarat between Jan-17 to Dec-17. Descriptive analysis was carried out by mean and standard deviation for quantitative variables, frequency and proportion for categorical variables. Data was also represented using appropriate diagrams like a bar diagram, pie diagram and box plots. The area of the ulcer was compared between the two groups, using independent sample t-test. The mean differences along with their 95% CI were presented. Association between quantitative explanatory and outcome variables was assessed by calculating the Pearson correlation coefficient and the data was represented with P-value. Conclusion: It can be concluded that Laser therapy is best-suited therapy for curing the diabetic foot ulcer as it is pain-free, effective on budget, wound contraction as well as re- epithelialisation helped in accelerating the curing of the wound with simple curing process following proper medication and instructions provided with laser therapy. Control of infection becomes easy as compared to any other techniques being used such as split skin grafting, and other secondary expensive procedures attempted to cure DFU.

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“…HSP coordinate the molecular signal transduction in response to different stress factors and during wound healing [89]. These stress proteins tend to be up‐regulated in all cell types exposed to increasing temperatures (i.e.…”

Section: Heat‐shock Proteinsmentioning

confidence: 99%

Epidermal and dermal changes in response to various skin rejuvenation methods

Helbig

Simon

Paasch

2010

Intern J of Cosmetic Sci

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During the last years, a number of new devices have been developed to improve the dermal and epidermal signs of photo- and chronological skin ageing. There are well-established ablative and non-ablative skin resurfacing options using different lasers and light sources, but side effects have been observed frequently. A recently developed photorejuvenation method using non-thermal stimulation of skin cells with low energy and narrow band light has been termed photomodulation. Light emitting diodes are the ideal source of this kind of light that stimulate mitochondrial cell organelles leading to up-regulation of cytochrome electron transport pathway leading to mitochondrial DNA gene modulation. This paper reviews the most current knowledge of intrinsic and extrinsic changes of ageing and summarizes different systems for skin rejuvenation with focus on non-thermal non-ablative skin rejuvenation modalities.

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Increased expression of heat shock protein 70 and heat shock factor 1 in chronic dermal ulcer tissues treated with laser-aided therapy

Cited by 21 publications

References 7 publications

HSF1 Drives a Transcriptional Program Distinct from Heat Shock to Support Highly Malignant Human Cancers

HSF1 Drives a Transcriptional Program Distinct from Heat Shock to Support Highly Malignant Human Cancers

Effect of Low-Level Laser Therapy on Diabetic Foot Ulcers

Epidermal and dermal changes in response to various skin rejuvenation methods

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