Increased expression of galectin-1 during the progression of cervical neoplasia

Kohrenhagen, N.; Völker, Hans-Ullrich; Kapp, Michaela; Dietl, Johannes; Kämmerer, Ulrike

doi:10.1111/j.1525-1438.2006.00741.x

Cited by 30 publications

(26 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…For cervical cancer, different studies have linked the galectins expression to host-parasite interaction [17], neoplastic transformation [18][19][20], sensitivity to concurrent chemoradiotherapy [21,22], tumorigenesis [23,24], and cell growth [25]. However, little is known about the role of Gal-1 in invasive cervical cancer, especially in terms of tumor proliferation, invasion, or metastasis.…”

Section: Introductionmentioning

confidence: 99%

Galectin 1 expression is associated with tumor invasion and metastasis in stage IB to IIA cervical cancer

Kim

Jeon

et al. 2013

Human Pathology

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Galectin 1 expression is associated with tumor invasion and metastasis in stage IB to IIA cervical cancer

Kim

Jeon

et al. 2013

Human Pathology

View full text Add to dashboard Cite

“…In squamous cervical cancer patients who received radiation therapy, a recent study reported that expression of galectin-1 by the tumor was an independent predictor for local recurrence and poor survival [27]. Expression of galectin-1 in the stroma of cervical cancer has also been correlated with higher histopathological grade [28] and lymph node metastasis [29]. Information about galectin-3 and galectin-9 expression in cervical cancer is limited.…”

Section: Introductionmentioning

confidence: 99%

Galectin-1, -3 and -9 Expression and Clinical Significance in Squamous Cervical Cancer

et al. 2015

View full text Add to dashboard Cite

Galectins are proteins that bind β-galactoside sugars and provide a new type of potential biomarkers and therapeutic targets in cancer. Galectin-1, -3 and -9 have become the focus of different research groups, but their expression and function in cervical cancer is still unclear. The aim of this study was to determine the phenotype of galectin-1, -3 and -9 expressing cells and the association with clinico-pathological parameters in cervical cancer. Galectin expression was scored in tumor cells, tumor epithelium infiltrating immune cells and stromal cells in squamous cervical cancer (n = 160). Correlations with clinico-pathological parameters and survival were studied according to the REMARK recommendations. We additionally investigated whether the galectins were expressed by tumor cells, fibroblasts, macrophages and T cells. Galectin-1 and -9 were both expressed by tumor cells in 11% of samples, while 84% expressed galectin-3. Strong galectin-1 expression by tumor cells was an independent predictor for poor survival (hazard ratio: 8.02, p = 0.001) and correlated with increased tumor invasion (p = 0.032) and receiving post-operative radiotherapy (p = 0.020). Weak and positive tumor cell galectin-3 expression were correlated with increased and decreased tumor invasion, respectively (p = 0.012). Tumor cell expression of galectin-9 showed a trend toward improved survival (p = 0.087). The predominant immune cell type expressing galectin-1, -3 and -9 were CD163+ macrophages. Galectin-1 and -3 were expressed by a minor population of T cells. Galectin-1 was mainly expressed by fibroblasts in the tumor stroma. To conclude, while tumor cell expression of galectin-9 seemed to represent a beneficial response, galectin-1 expression might be used as a marker for a more aggressive anti-cancer treatment.

show abstract

“…In addition, it exists intracellularly and interacts with cytoplasmic and nuclear proteins to regulate cell transformation (14) or pre-mRNA splicing (15). Immunohistochemical staining of Gal-1 in clinical cancer samples reveals that its expression is positively associated with the malignant progression of many tumor types, including glioma (16), prostate (17), colon (18), breast (19), cervical (20), and oral squamous (21) cells. The expression of Gal-1 in carcinoma-associated stromal cells was significantly correlated with breast tumor invasiveness and lymph node metastasis (19).…”

Section: Introductionmentioning

confidence: 99%

Galectin-1-Mediated Tumor Invasion and Metastasis, Up-Regulated Matrix Metalloproteinase Expression, and Reorganized Actin Cytoskeletons

Wu¹,

Hong

Cheng³

et al. 2009

Molecular Cancer Research

135

110

View full text Add to dashboard Cite

Galectin-1 (Gal-1) is a B-galactose-binding lectin; its expression level has been reported to correlate with tumor progression. Gal-1 is highly expressed in the invasive front of primary tumors and in the cancer cells of metastatic lesions in the lymph nodes of patients with oral squamous cell carcinoma. However, the molecular mechanism of Gal-1 in tumor metastasis is not completely clear. We found that increased Gal-1 expression is closely associated with its high levels of invasion in lung adenocarcinoma and oral squamous cell carcinoma cell lines. Knocking down Gal-1 with small interfering RNA in highly invasive cancer cells reduced their invasion levels. Moreover, the invasion ability of poorly invasive cancer cells was significantly increased after Gal-1 overexpression of Gal-1. Mechanism studies revealed that Gal-1 promoted tumor invasion mainly by up-regulating matrix metalloproteinase (MMP)-9 and MMP-2 and by reorganizing actin cytoskeleton. Gal-1 enhanced the activation of Cdc42, a small GTPase and member of the Rho family, thus increasing the number and length of filopodia on tumor cells. Furthermore, Gal-1-overexpressing cells had higher metastatic abilities in tail vein metastasis assays in vivo. We conclude that Gal-1 is involved in tumor invasion and metastasis by increasing MMP expression and reorganizing cytoskeletons in oral cancers and lung adenocarcinoma. (Mol Cancer Res 2009;7(3):311 -8)

show abstract

Increased expression of galectin-1 during the progression of cervical neoplasia

Cited by 30 publications

References 40 publications

Galectin 1 expression is associated with tumor invasion and metastasis in stage IB to IIA cervical cancer

Galectin 1 expression is associated with tumor invasion and metastasis in stage IB to IIA cervical cancer

Galectin-1, -3 and -9 Expression and Clinical Significance in Squamous Cervical Cancer

Galectin-1-Mediated Tumor Invasion and Metastasis, Up-Regulated Matrix Metalloproteinase Expression, and Reorganized Actin Cytoskeletons

Contact Info

Product

Resources

About