Increased Expression of Fibroblast Activation Protein is Associated with Autophagy Dysregulation and Oxidative Stress in Obese Women with Uterine Fibroids

Maghraby, Nashwa; Noweihi, Amira M El; El-Melegy, Nagla T; Mostafa, Nashwa; Abbas, Ahmed M.; El-Deek, Heba E M; Radwan, Eman

doi:10.1007/s43032-021-00810-0

Cited by 5 publications

(10 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Research has shown the impact of oxidative stress on autophagy with ROS and reactive nitrogen species (RNS), acting as important intracellular signal transducers to sustain autophagy [ 36 ]. Autophagy has specifically been shown to occur in uterine fibroids [ 11 ]. There are higher levels of microtubule-associated proteins 1A/1B light chain 3B (LC3), an autophagy marker, and malondialdehyde (MAD), a marker of oxidative stress, in fibroid tissue compared to normal myometrial tissue [ 11 ].…”

Section: Pathophysiological Considerationsmentioning

confidence: 99%

“…Autophagy has specifically been shown to occur in uterine fibroids [ 11 ]. There are higher levels of microtubule-associated proteins 1A/1B light chain 3B (LC3), an autophagy marker, and malondialdehyde (MAD), a marker of oxidative stress, in fibroid tissue compared to normal myometrial tissue [ 11 ]. Autophagy markers also showed significant positive correlations with MAD and inflammatory cytokines such as TNF-α and TGF-β3 [ 11 ].…”

Section: Pathophysiological Considerationsmentioning

confidence: 99%

“…There are higher levels of microtubule-associated proteins 1A/1B light chain 3B (LC3), an autophagy marker, and malondialdehyde (MAD), a marker of oxidative stress, in fibroid tissue compared to normal myometrial tissue [ 11 ]. Autophagy markers also showed significant positive correlations with MAD and inflammatory cytokines such as TNF-α and TGF-β3 [ 11 ]. These results support that oxidative stress, autophagy dysregulation, and inflammation may contribute to the development of uterine fibroids in women [ 11 ].…”

Section: Pathophysiological Considerationsmentioning

confidence: 99%

“…Autophagy markers also showed significant positive correlations with MAD and inflammatory cytokines such as TNF-α and TGF-β3 [ 11 ]. These results support that oxidative stress, autophagy dysregulation, and inflammation may contribute to the development of uterine fibroids in women [ 11 ].…”

Section: Pathophysiological Considerationsmentioning

confidence: 99%

“…Oxidative stress is the imbalance between prooxidants and antioxidants, and this imbalance is controlled by interconnecting cascades that involve angiogenesis, hypoxia, dietary factors, and smoking/environmental exposures, among others [ 7 , 8 , 9 , 10 ]. Oxidative stress in turn drives fibroid development through its impact on genetics, epigenetics, and fibrogenesis [ 11 , 12 , 13 ]. Further exploring the relationship between oxidative stress and fibroids not only would enhance our understanding of fibroid pathobiology but also could introduce and establish several diagnostic and therapeutic implications specifically designed to target this association ( Figure 1 ).…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Oxidative Stress and Antioxidants in Uterine Fibroids: Pathophysiology and Clinical Implications

et al. 2023

View full text Add to dashboard Cite

In the last few decades, our understanding of the complex pathobiology of uterine fibroid development has grown. While previously believed to be a purely neoplastic entity, we now understand that uterine fibroids possess different and equally important aspects of their genesis. An increasing body of evidence suggests that oxidative stress, the imbalance between pro- and antioxidants, is an important factor in fibroid development. Oxidative stress is controlled by multiple, interconnecting cascades, including angiogenesis, hypoxia, and dietary factors. Oxidative stress in turn influences fibroid development through genetic, epigenetic, and profibrotic mechanisms. This unique aspect of fibroid pathobiology has introduced several clinical implications, both diagnostic and therapeutic, that can aid us in managing these debilitating tumors by using biomarkers as well as dietary and pharmaceutical antioxidants for diagnosis and treatment. This review strives to summarize and add to the current evidence revealing the relationship between oxidative stress and uterine fibroids by elucidating the proposed mechanisms and clinical implications.

show abstract

Section: Pathophysiological Considerationsmentioning

confidence: 99%

Section: Pathophysiological Considerationsmentioning

confidence: 99%

Section: Pathophysiological Considerationsmentioning

confidence: 99%

Section: Pathophysiological Considerationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Oxidative Stress and Antioxidants in Uterine Fibroids: Pathophysiology and Clinical Implications

et al. 2023

View full text Add to dashboard Cite

show abstract

From basic research to clinical application: targeting fibroblast activation protein for cancer diagnosis and treatment

Zhang,

Tao,

Qiu

et al. 2023

Cell Oncol.

View full text Add to dashboard Cite

Shifting paradigms in uterine fibroids treatment: insights from current therapeutic approaches

Vázquez Ruvalcaba,

García,

Cornejo

et al. 2023

Int J Reprod Contracept Obstet Gynecol

View full text Add to dashboard Cite

This review examined the effectiveness of ulipristal acetate (UPA) compared to leuprolide acetate (LEU) in the treatment of symptomatic uterine fibroids. The primary objective was to analyze relevant studies that investigated the improvement of symptoms, complications, alternative treatment options, and surgical outcomes for fibroids. Using the PICO format as a research approach, various aspects were compared for each treatment, including diagnostic accuracy, side effects, quality of life, and patient satisfaction measured through the Uterine fibroid symptoms and quality of life scale. UPA proved to be a safe, well-tolerated, and effective treatment option for symptomatic uterine fibroids, leading to amenorrhea and reduced heavy menstrual bleeding. On the other hand, LEU also effectively reduced fibroid size but had a higher incidence of adverse events such as hot flashes, vaginal dryness, and decreased bone density. It is crucial to consider all the aforementioned factors when selecting the most suitable treatment option for individual patients, as each treatment has its own advantages and disadvantages, including dosing requirements, side effects, endometrial changes, and their impact on treatment adherence and outcomes. Currently, there is limited evidence supporting the superiority of UPA over other drugs like LEU in short-term therapy for symptomatic uterine fibroids. Further research is necessary to establish UPA as a reliable and promising alternative. Treatment decisions should be individualized, taking into account patient comorbidities and considering both surgical and conservative approaches.

show abstract

Increased Expression of Fibroblast Activation Protein is Associated with Autophagy Dysregulation and Oxidative Stress in Obese Women with Uterine Fibroids

Cited by 5 publications

References 61 publications

Oxidative Stress and Antioxidants in Uterine Fibroids: Pathophysiology and Clinical Implications

Oxidative Stress and Antioxidants in Uterine Fibroids: Pathophysiology and Clinical Implications

From basic research to clinical application: targeting fibroblast activation protein for cancer diagnosis and treatment

Shifting paradigms in uterine fibroids treatment: insights from current therapeutic approaches

Contact Info

Product

Resources

About