Increased Expression of Fc-γ Receptors on Monocytes in Patients With Nascent Metabolic Syndrome

Devaraj, Sridevi; Chen, Xinpu; Adams‐Huet, Beverley; Jialal, Ishwarlal

doi:10.1210/jc.2013-2112

Cited by 15 publications

(10 citation statements)

References 30 publications

(46 reference statements)

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“…10 In addition, alveolar macrophages generally express high levels of CD32. 11 Interestingly, individuals with the previously mentioned underlying medical conditions such as diabetes and cardiovascular diseases express high levels of CD32 on their innate immune cells 12,13 due to elevated Creactive protein (CRP) level. CD32 on monocytes or macrophages can transduce inflammatory signalling in the presence of IgG and result in the production of IFN-c, TNF-a, IL-1b and IL-6.…”

Section: Pathology and Immunology Of Covid-19mentioning

confidence: 99%

Trained immunity as a novel approach against COVID‐19 with a focus on Bacillus Calmette–Guérin vaccine: mechanisms, challenges and perspectives

et al. 2020

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COVID‐19 is a severe health problem in many countries and has altered day‐to‐day life in the whole world. This infection is caused by the SARS‐CoV‐2 virus, and depending on age, sex and health status of the patient, it can present with variety of clinical symptoms such as mild infection, a very severe form or even asymptomatic course of the disease. Similarly to other viruses, innate immune response plays a vital role in protection against COVID‐19. However, dysregulation of innate immunity could have a significant influence on the severity of the disease. Despite various efforts, there is no effective vaccine against the disease so far. Recent data have demonstrated that the Bacillus Calmette–Guérin (BCG) vaccine could reduce disease severity and the burden of several infectious diseases in addition to targeting its primary focus tuberculosis. There is growing evidence for the concept of beneficial non‐specific boosting of immune responses by BCG or other microbial compounds termed trained immunity, which may protect against COVID‐19. In this manuscript, we review data on how the development of innate immune memory due to microbial compounds specifically BCG can result in protection against SARS‐CoV‐2 infection. We also discuss possible mechanisms, challenges and perspectives of using innate immunity as an approach to reduce COVID‐19 severity.

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Section: Pathology and Immunology Of Covid-19mentioning

confidence: 99%

Trained immunity as a novel approach against COVID‐19 with a focus on Bacillus Calmette–Guérin vaccine: mechanisms, challenges and perspectives

et al. 2020

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“…Dysfunction can be acquired as cell exhaustion after extensive sepsis . However, inappropriate responses can induce life threatening cytokine storms (septic shock), granulomatosis, or more insidious slowly progressing inflammation that contributes to chronic metabolic syndrome , atherosclerosis , and other degenerative disorders . Macrophage contribution has even been shown in neuropsychiatric disorders, such as “mild encephalitis” or Alzheimer's disease .…”

Section: Pathologymentioning

confidence: 99%

Monocytes and macrophages in flow: an ESCCA initiative on advanced analyses of monocyte lineage using flow cytometry

Lambert

Preijers

Demirel

et al. 2015

Cytometry Part B Clinical

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In April 2013, a symposium was organized to highlight different aspects of differentiation and activation of the monocyte-macrophage lineage as analyzed on the flow cytometer. Characterization of this lineage requires knowledge of the maturation process from their progenitors that are present in bone marrow up to the mature monocytic cells in peripheral blood, because each monocytic lineage cell with an aberrant phenotype refers to the corresponding maturation stage. A standardized quantitative analysis will facilitate the monitoring of the pathological processes and the clinical features, such as the outcome of treatment. However, changes in marker expression by variation in intensity, asynchronism, and lineage infidelity must be considered. The dynamics of normal marker expressions in early differentiation stages, e.g. molecules like HLA II, CD64 or CD14, give rise to a hypothesis on their possible role in monocyte ontogeny. Besides their usual role in tissue homeostasis, mature macrophages may also play a similar role in hematopoiesis. This meeting highlighted the large potential of flow cytometric tools available for monitoring of all these aspects in the monocytic and macrophage cell lineage. © 2015 International Clinical Cytometry Society.

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“…Furthermore, the course of COVID-19 is in general more severe in those with underlying conditions such as hypertension, poorly controlled diabetes mellitus, and cardiovascular disease among others (4). This may be attributed to the known increased expression of CD32a on monocytes and macrophages in these patients (24). However, it is a common assumption that immunocompromised patients are at increased risk of developing severe COVID-19.…”

mentioning

confidence: 99%

COVID-19: an Immunopathological View

Kadkhoda

2020

mSphere

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Since its emergence in December 2019, it took only a couple of months for an outbreak of the novel coronavirus disease 2019 (COVID-19) to be declared a pandemic by the World Health Organization (WHO). This along with the highly infectious nature of the disease and the associated mortality call for particular attention to the underlying (immuno)pathomechanism(s). The latter will inform case management and vaccine design. Unravelling these mechanisms can assist basic scientists, laboratory medicine practitioners, clinicians, public health practitioners, funding agencies, and health care policymakers in responding to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic.

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Increased Expression of Fc-γ Receptors on Monocytes in Patients With Nascent Metabolic Syndrome

Abstract: We provide novel evidence of increased FcgR expression and activity in monocytes of patients with MetS that correlates with the number of features of MetS and with high-sensitivity CRP.

Cited by 15 publications

References 30 publications

Trained immunity as a novel approach against COVID‐19 with a focus on Bacillus Calmette–Guérin vaccine: mechanisms, challenges and perspectives

Trained immunity as a novel approach against COVID‐19 with a focus on Bacillus Calmette–Guérin vaccine: mechanisms, challenges and perspectives

Monocytes and macrophages in flow: an ESCCA initiative on advanced analyses of monocyte lineage using flow cytometry

COVID-19: an Immunopathological View

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