Increased expression of Fc  receptors on neutrophils and monocytes may reflect ongoing bacterial infection

Abstract

The FcyR receptors for IgG, FcyRI, FcyRII and FcyRIII were measured on neutrophils and monocytes from 36 patients suspected of systemic infection. These results were compared with 30 blood donor controls to assess the level of expression as an early indicator of bacterial infection. FcyRI expression on neutrophils was found to be significantly increased from patients with systemic or localised infections, when compared to the non-infected patient group, i.e., patients with no cultural evidence of bacterial infections, (p = 0.02, p = 0.04) or normal controls (p C 0.0001, p = 0.0005). FcyRI expression on monocytes was also significantly increased in both of the infected groups compared to normal controls (p < 0.0001, p = 0.001); however, no significant difference could be seen when compared with the non-infected patients. Fc yRIII was found to be significantly increased on a subset of monocytes in patients with systemic or localised infections compared to the non-infected group (p = 0.009, p = 0.006) and compared to the normal controls (p = 0.009, p = 0.003). Infections caused by gramnegative bacilli induced a higher FcyR response than infection with either streptococci or staphylococci. These data suggest that the measurement of FcyRI on neutrophils and FcyRIII on monocytes may be a useful rapid indicator of bacterial infection.

Neutrophil CD64 Expression: A Sensitive Diagnostic Marker for Late-Onset Nosocomial Infection in Very Low Birthweight Infants

“…During bacterial infection, the expression of CD64 on activated neutrophils was markedly increased (18,33,34). More important, it has also been shown that neutrophils of preterm infants expressed CD64 antigen to an extent similar to those of older children and adults (18).…”

Ratios of CD64 expressed on neutrophils, monocytes, and lymphocytes may be a novel method for diagnosis of neonatal sepsis

“…Neutrophil CD64 expression is a useful biomarker for improving the diagnosis and management of hospital patients with bacterial infections [4,8]. Also, it can be incorporated as a valuable marker to exclude neonatal sepsis (NS) [9][10][11][12][13][14].…”

Influence of surgical treatment and radiotherapy of the advanced intraoral cancers on complete blood count, body mass index, liver enzymes and leukocyte CD64 expression

“…61 During bacterial infections, however, the neutrophil expression of CD64 is markedly increased. [63][64][65] Studies have confirmed that the level of CD64 expression is significantly higher in patients with infectious SIRS as compared to patients with noninfectious SIRS as well as adults and children. 66,67 All the indexes in our group were within the normal range, although surgery is known to elevate the levels of CD64 expression on monocytes and neutrophils.…”