Rachel Whitaker, Shakeela Faulkner, Reika Miyokawa, Lucas Burhenn, Mark Henriksen, Jason G. Wood, Stephen L. Helfand
Abstract:Sir2, a member of the sirtuin family of protein acylases, deacetylates lysine residues within many proteins and is associated with lifespan extension in a variety of model organisms. Recent studies have questioned the positive effects of Sir2 on lifespan in Drosophila. Several studies have shown that increased expression of the Drosophila Sir2 homolog (dSir2) extends life span while other studies have reported no effect on life span or suggested that increased dSir2 expression was cytotoxic. To attempt to reco…
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