Increased Expression of DNAJC12 is Associated with Aggressive Phenotype of Gastric Cancer

Uno, Yoji; Kanda, Mitsuro; Miwa, Takashi; Umeda, Shinichi; Tanaka, Haruyoshi; Tanaka, Chie; Kobayashi, Daisuke; Suenaga, Masaya; Hattori, Norifumi; Hayashi, Masamichi; Yamada, Suguru; Nakayama, Goro; Fujiwara, Michitaka; Kodera, Yasuhiro

doi:10.1245/s10434-018-07149-y

Cited by 23 publications

(27 citation statements)

References 32 publications

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“…HSP40 assists in protein folding, unfolding, translation, translocation, and degradation [11,25,26], as well as ATPase activity of HSP70 [27]. Many of the HSP40 family members are overexpressed in numerous human cancer types, such as colorectal, gastric, and lung cancers [28][29][30][31]. Clinicopathologic analyses have shown the markedly increased expression of DnaJA1 in colorectal cancer (CRC) tissues, particularly those of which had developed metastases in lymph node and distant organs.…”

Section: Oncogenic Role Of Hsp40 In Proliferation and Metastasis Of Cmentioning

confidence: 99%

“…The transcriptome analysis has identified that the increased expression of DnaJC12 is correlated with lymphatic invasion, infiltrative growth type, lymph node metastasis, and progression of gastric cancer. The patients with increased levels of DnaJC12, therefore, have higher morbidity and mortality rates, suggesting DnaJC12 as a potent therapeutic target [30].…”

Section: Oncogenic Role Of Hsp40 In Proliferation and Metastasis Of Cmentioning

confidence: 99%

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Heat Shock Proteins: Agents of Cancer Development and Therapeutic Targets in Anti-Cancer Therapy

Yun

Kim

Lim

et al. 2019

Cells

187

158

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Heat shock proteins (HSPs) constitute a large family of molecular chaperones classified by their molecular weights, and they include HSP27, HSP40, HSP60, HSP70, and HSP90. HSPs function in diverse physiological and protective processes to assist in maintaining cellular homeostasis. In particular, HSPs participate in protein folding and maturation processes under diverse stressors such as heat shock, hypoxia, and degradation. Notably, HSPs also play essential roles across cancers as they are implicated in a variety of cancer-related activities such as cell proliferation, metastasis, and anti-cancer drug resistance. In this review, we comprehensively discuss the functions of HSPs in association with cancer initiation, progression, and metastasis and anti-cancer therapy resistance. Moreover, the potential utilization of HSPs to enhance the effects of chemo-, radio-, and immunotherapy is explored. Taken together, HSPs have multiple clinical usages as biomarkers for cancer diagnosis and prognosis as well as the potential therapeutic targets for anti-cancer treatment.

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Section: Oncogenic Role Of Hsp40 In Proliferation and Metastasis Of Cmentioning

confidence: 99%

Section: Oncogenic Role Of Hsp40 In Proliferation and Metastasis Of Cmentioning

confidence: 99%

Heat Shock Proteins: Agents of Cancer Development and Therapeutic Targets in Anti-Cancer Therapy

Yun

Kim

Lim

et al. 2019

Cells

187

158

View full text Add to dashboard Cite

show abstract

“…For instance, in patients with rectal cancer, upregulated expression levels of dNAJc12 have been shown to predict a poor response to neoadjuvant concurrent chemoradiotherapy (11). The aggressive phenotype of gastric cancer has also been found to be associated with the upregulation of dNAJc12 expression levels (12). In addition, in breast cancer, dNAJc12 expression has been found to be associated with the estrogen receptor status (13).…”

Section: Dnajc12 Promotes Lung Cancer Growth By Regulating the Activation Of β-Cateninmentioning

confidence: 99%

DNAJC12 promotes lung cancer growth by regulating the activation of β‑catenin

Li²,

Jin

et al. 2021

Int J Mol Med

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Lung cancer has become the leading cause of cancer-associated mortality worldwide. However, the under- lying mechanisms of lung cancer remain poorly understood. DnaJ heat shock protein family (HSP40) member C12 (DNAJC12) is a type III member belonging to the HSP40/DNAJ family. The role of DNAJC12 in numerous types of cancer has been previously reported; however, the effect of DNAJC12 in lung cancer remains unknown. The results of the present study indicated that DNAJC12 may be involved in lung cancer proliferation and migration by regulating the β-catenin signaling pathway. Data generated in the present study and from The Cancer Genome Atlas revealed that the DNAJC12 expression levels were significantly upregulated in lung cancer tissues compared with non-cancer lung tissues. The expression of DNAJC12 was subsequently knocked down in A549 and NCI-H1975 lung cancer cells using lentiviral transfections and further experiments demonstrated that the knockdown of DNAJC12 inhibited the proliferation, colony formation, migration and invasion of lung cancer cells. The results of flow cytometric assays also revealed that the knockdown of DNAJC12 induced the apoptosis of lung cancer cells. In addition, the effects of DNAJC12 knockdown on the in vivo growth of lung cancer cells were observed. Signaling pathway analysis revealed that the knockdown of DNAJC12 expression suppressed the phosphorylation of p65 NF-κB, downregulated the expression levels and inhibited the subsequent activation of β-catenin, and downregulated the expression levels of vimentin. Rescue experiments demonstrated that the over- expression of β-catenin, but not that of NF-κB or vimentin, reversed the effects of DNAJC12 knockdown on the proliferation and invasion of lung cancer cells. On the whole, the findings of the present study suggest that DNAJC12 may play a crucial role in lung cancer tumorigenesis by regulating the expression and activation of β-catenin. Therefore, DNAJC12 may represent a novel target for the treatment of lung cancer.

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“…DNAJC12, also known as JDP1 or HPANBH4, is a member of the DnaJ heat shock protein family (Hsp40) C12 ( 33 , 34 ). The mRNA expression level of DNAJC12 is generally higher in breast carcinoma ( 35 ), especially in ESR1-positive breast carcinoma tissues ( 36 ).…”

Section: Introductionmentioning

confidence: 99%

DNAJC12 as a Mediator Between ESR1 and ERBB4 in Breast Carcinoma Cells

Lin

Wang

et al. 2021

Front. Oncol.

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Mutation of the DNAJC12 gene is typically associated with non-progressive Parkinsonism, but is also detectable in breast carcinoma where its contribution and mechanisms are unexplored. In breast carcinoma, ESR1 was positively correlated with DNAJC12 and ERBB4, and DNAJC12 was positively correlated with ERBB4. We used the GEO2R tool to compare differential gene expression of MCF-7 cells, following ESR1 knockdown (GEO database, E-GEOD-27473 array), and found decreased expression of DNAJC12 and ERBB4 in ESR1-silenced MCF-7 cells. The number of identical genes having correlativity with ESR1, DNAJC12, or ERBB4 was 12,165 (66.41%). These results suggest that ESR1 can promote the expression of DNAJC12 and ERBB4, and DNAJC12 can enhance the expression of ERBB4 in MCF-7 cells, implying that there may be a regulatory network among these three genes.

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Increased Expression of DNAJC12 is Associated with Aggressive Phenotype of Gastric Cancer

Cited by 23 publications

References 32 publications

Heat Shock Proteins: Agents of Cancer Development and Therapeutic Targets in Anti-Cancer Therapy

Heat Shock Proteins: Agents of Cancer Development and Therapeutic Targets in Anti-Cancer Therapy

DNAJC12 promotes lung cancer growth by regulating the activation of β‑catenin

DNAJC12 as a Mediator Between ESR1 and ERBB4 in Breast Carcinoma Cells

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