Increased expression of Dkk1 by HR is associated with alteration of hair cycle in hairpoor mice

Kim, Bong-Kyu; Lee, Hwa Young; Kim, In Jung; Choi, Kyu-Yong; Park, Jong–Keun; Yoon, Sungjoo Kim

doi:10.1016/j.jdermsci.2013.12.007

Cited by 15 publications

(20 citation statements)

References 37 publications

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“…CRC paraffin sections were obtained from the Department of Pathology in the College of Medicine at the Catholic University of Korea. Immunohistochemistry was performed as described previously (43) . Briefly, CRC paraffin wax sections were fixed prior to antigen retrieval.…”

Section: Methodsmentioning

confidence: 99%

FZD6 expression is negatively regulated by miR-199a-5p in human colorectal cancer

et al. 2015

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Colorectal cancer (CRC), the third most common cancer worldwide, also has the highest rate of cancer-related morbidity and mortality. WNT signaling is initiated by binding of WNT to various receptors, including frizzleds (FZDs), and plays a critical role in CRC and other tumor development by regulating proliferation, differentiation, migration, apoptosis, and polarity. Among the members of the FZD family, FZD6 is broadly expressed in various tissues, and its overexpression has been reported in several cancers, suggesting an important role in cancer development. In this study, we investigated the expression of FZD6 in patients with CRC and found it to be increased in tumors, as compared to paired adjacent non-tumor tissues. Additionally, we found that FZD6 expression was negatively regulated by miR199a5p in CRC cells. These results suggest that overexpression of FZD6, mediated by reduced expression of miR-199a-5p, may play an important role in the development of CRC. [BMB Reports 2015; 48(6): 360-366]

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Section: Methodsmentioning

confidence: 99%

FZD6 expression is negatively regulated by miR-199a-5p in human colorectal cancer

et al. 2015

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“…Strong expression of Tgf‐β2 in all hair component and hair remnants in Hr Hp / Hr Hp mice suggested that these mice were under continuous inhibition of HF growth and in the state of induction of regression phase of HF. Moreover, we recently reported that Hr Hp heterozygote mice underwent earlier catagen onset through a shortened anagen phase and early maturation of HFs as compared to wild type mice (Kim et al, ). In addition, a recent study revealed that Tgf‐β2 also has a critical role in telogen–anagen transition through Tmeff1 activation (Oshimori and Fuchs, ).…”

Section: Discussionmentioning

confidence: 99%

“…Mardaryev et al () demonstrated that Krt16 , Krt17 , Dlx3 , and Fgf10 were the direct targets of miR‐31 using a luciferase reporter system. Among these target genes, we found that Dkk1 mRNA was up‐regulated in the skin of Hr Hp / Hr Hp mice (Kim et al, ). In the current study, we also found that Fgf10 mRNA was up‐regulated in the skin of Hr Hp / Hr Hp mice (Fig.…”

Section: Discussionmentioning

confidence: 99%

Hairless Up‐Regulates Tgf‐β2 Expression via Down‐Regulation of miR‐31 in the Skin of “Hairpoor” (Hr^Hp) Mice

Kim

Yoon

2015

Journal Cellular Physiology

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Hairless (HR) has been shown to regulate hair follicle (HF) morphogenesis and hair cycling. The Hr mutant hair loss mouse referred to as "hairpoor" (Hr(Hp)) displays overexpression of the HR protein through translational derepression. In this study, we found that 64 miRNAs were differentially expressed between the skin of Hr(Hp)/Hr(Hp) and wild type mice at P7 using miRNA-microarray analysis and miR-31 displayed the most reduced expression in Hr(Hp)/Hr(Hp) skin. In vivo observation and investigation using an in vitro reporter expression system revealed that miR-31 and pri-miR-31 were consistently down-regulated in the HR over-expressed condition. In addition, we found that the transforming growth factor β2 (Tgf-β2), a known catagen inducer, is the putative target of miR-31. Furthermore, Tgf-β2 level was also increased in HR over-expressed keratinocyte and Hr(Hp)/Hr(Hp) mice. These study results suggest that HR controls Tgf-β2 expression via regulation of miR-31, thus causing abnormal hair cycle in Hr(Hp)/Hr(Hp) mice.

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“…The only exception is Sfrp1 that also suppresses Wnt, but is downregulated by Hr [76,82]. Since the hair follicle downgrowth has to be stopped at the end of organogenesis, Wnt signaling, as a central stimulator of cell proliferation, has to be indeed stopped.…”

Section: Cytodifferentiationmentioning

confidence: 99%

A guide for building biological pathways along with two case studies: hair and breast development

Trindade

Orsine

Barbosa-Silva

et al. 2015

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Increased expression of Dkk1 by HR is associated with alteration of hair cycle in hairpoor mice

Cited by 15 publications

References 37 publications

FZD6 expression is negatively regulated by miR-199a-5p in human colorectal cancer

FZD6 expression is negatively regulated by miR-199a-5p in human colorectal cancer

Hairless Up‐Regulates Tgf‐β2 Expression via Down‐Regulation of miR‐31 in the Skin of “Hairpoor” (Hr^Hp) Mice

A guide for building biological pathways along with two case studies: hair and breast development

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Increased expression of Dkk1 by HR is associated with alteration of hair cycle in hairpoor mice

Cited by 15 publications

References 37 publications

FZD6 expression is negatively regulated by miR-199a-5p in human colorectal cancer

FZD6 expression is negatively regulated by miR-199a-5p in human colorectal cancer

Hairless Up‐Regulates Tgf‐β2 Expression via Down‐Regulation of miR‐31 in the Skin of “Hairpoor” (HrHp) Mice

A guide for building biological pathways along with two case studies: hair and breast development

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Hairless Up‐Regulates Tgf‐β2 Expression via Down‐Regulation of miR‐31 in the Skin of “Hairpoor” (Hr^Hp) Mice