Increased expression of adhesion receptors in both lesional and non-lesional psoriatic skin

Boer, Onno J. de; Wakelkamp, I. M. M. J.; Pals, Steven T.; Claessen, Nike; Bos, Jan D.; Das, Pranab K.

doi:10.1007/bf00402220

Cited by 72 publications

(43 citation statements)

References 45 publications

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“…The overexpression of ICAM-1, VCAM-1 and E-selectin in psoriatic lesions is well documented [27]. In our study, the significant reductions in the expression of these markers and the pathological scores were observed after treatment, corroborating the results of the early studies.…”

Section: Discussionsupporting

confidence: 81%

A Novel Transdermal Plasmid-Dimethylsulfoxide Delivery Technique for Treatment of Psoriasis

Zhang

Liu

et al. 2010

Dermatology

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Background: Psoriasis is a chronic and relapsing inflammatory skin disease associated with various immunologic abnormalities. Repeated subcutaneous injection of interleukin-4 (IL-4) has been established as an effective treatment to counteract psoriasis. Objective: We investigated whether gene therapy using IL-4 expression plasmid (pIL-4) via transdermal delivery was an alternative treatment for psoriasis. In our experiment, dimethylsulfoxide (DMSO) was used as a penetration enhancer. Methods: At first, the penetration efficiency of the complex of reporter plasmid accompanied by DMSO was investigated both in vitro and in vivo. Then, the antipsoriasis efficiency of the treatment with pIL-4-DMSO was tested in mice. Results: The expression of the reporter gene was detected in epidermis and dermis both in vitro and in vivo. More importantly, the psoriasis symptoms were relieved, and significant reductions in some psoriasis-associated factors were observed after pIL-4-DMSO treatment. Conclusion: We conclude that the topical application of pIL-4-DMSO can treat psoriasis to a significant extent.

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Section: Discussionsupporting

confidence: 81%

A Novel Transdermal Plasmid-Dimethylsulfoxide Delivery Technique for Treatment of Psoriasis

Zhang

Liu

et al. 2010

Dermatology

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“…The first step of recruitment of leukocytes to the skin is the attachment of circulating cells to vascular endothelial cells, which is mediated by cell adhesion molecules, such as ICAM-1, VCAM-1, and Eselectin (21). It has been shown that the expression of these cell adhesion molecules is increased on dermal vessels of psoriatic skin (22)(23)(24)(25). To test the effect of miR-31 on endothelial cell-activating capacity of keratinocytes, we measured the expressions of ICAM-1, VCAM-1, and E-selectin in primary HUVECs incubated with culture medium from miR-31 inhibitor-treated keratinocytes.…”

Section: Mir-31 Regulates the Production Of Inflammatory Mediators Inmentioning

confidence: 99%

MicroRNA-31 Is Overexpressed in Psoriasis and Modulates Inflammatory Cytokine and Chemokine Production in Keratinocytes via Targeting Serine/Threonine Kinase 40

Meisgen

Butler

et al. 2013

The Journal of Immunology

177

206

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Psoriasis is characterized by a specific microRNA expression profile, distinct from that of healthy skin. MiR-31 is one of the most highly overexpressed microRNAs in psoriasis skin; however, its biological role in the disease has not been studied. In this study, we show that miR-31 is markedly overexpressed in psoriasis keratinocytes. Specific inhibition of miR-31 suppressed NF-κB–driven promoter luciferase activity and the basal and TNF-α–induced production of IL-1β, CXCL1/growth-related oncogene-α, CXCL5/epithelial-derived neutrophil-activating peptide 78, and CXCL8/IL-8 in human primary keratinocytes. Moreover, interference with endogenous miR-31 decreased the ability of keratinocytes to activate endothelial cells and attract leukocytes. By microarray expression profiling, we identified genes regulated by miR-31 in keratinocytes. Among these genes, we identified serine/threonine kinase 40 (STK40), a negative regulator of NF-κB signaling, as a direct target for miR-31. Silencing of STK40 rescued the suppressive effect of miR-31 inhibition on cytokine/chemokine expression, indicating that miR-31 regulates cytokine/chemokine expression via targeting STK40 in keratinocytes. Finally, we demonstrated that TGF-β1, a cytokine highly expressed in psoriasis epidermis, upregulated miR-31 expression in keratinocytes in vitro and in vivo. Collectively, our findings suggest that overexpression of miR-31 contributes to skin inflammation in psoriasis lesions by regulating the production of inflammatory mediators and leukocyte chemotaxis to the skin. Our data indicate that inhibition of miR-31 may be a potential therapeutic option in psoriasis.

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“…21,22 In a meta-analysis comprising 78 studies, increased levels of sICAM-1 and sE-selectin were detected in the serum of psoriasis patients. 23 MMPs degrade extracellular matrix components and are regarded as key regulatory molecules in the pathogenesis of cardiovascular disease.…”

Section: T Cells and Langerhans Cells Of The Inflammatory Infiltratementioning

confidence: 99%

Systemic treatment and narrowband ultraviolet B differentially affect cardiovascular risk markers in psoriasis

Sigurdardottir

Ekman

Ståhle

et al. 2014

Journal of the American Academy of Dermatology

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Increased expression of adhesion receptors in both lesional and non-lesional psoriatic skin

Cited by 72 publications

References 45 publications

A Novel Transdermal Plasmid-Dimethylsulfoxide Delivery Technique for Treatment of Psoriasis

A Novel Transdermal Plasmid-Dimethylsulfoxide Delivery Technique for Treatment of Psoriasis

MicroRNA-31 Is Overexpressed in Psoriasis and Modulates Inflammatory Cytokine and Chemokine Production in Keratinocytes via Targeting Serine/Threonine Kinase 40

Systemic treatment and narrowband ultraviolet B differentially affect cardiovascular risk markers in psoriasis

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