Increased Exhaled Nitric Oxide Following Autologous Peripheral Hematopoietic Stem-Cell Transplantation

Qureshi, Mohammad Azfar; Girgis, Reda E.; Dandapantula, Hari Kumar; Abrams, Judith; Soubani, Ayman O.

doi:10.1378/chest.125.1.281

Cited by 13 publications

(7 citation statements)

References 45 publications

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“…In contrast to immunocompetent children [7,19], no data exist on normal FeNO levels in immunosuppressed children or on the predictive value of elevated FeNO for pulmonary complications after paediatric allogeneic HSCT. FeNO levels were generally lower in our cohort than in the adult study by Kanamori or in adult patients following autologous HSCT after breast carcinoma [24], reflecting the fact that norm values in immunocompetent children are also lower than in adults. Notably, FeNO levels did not correlate significantly with pulmonary function parameters such as FEV1, FVC or TLC.…”

Section: Discussioncontrasting

confidence: 57%

Exhaled nitric oxide and pulmonary complications after paediatric stem cell transplantation

et al. 2012

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Section: Discussioncontrasting

confidence: 57%

Exhaled nitric oxide and pulmonary complications after paediatric stem cell transplantation

et al. 2012

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“…The lung is particularly sensitive because of its oxygen-rich environment. Exhaled nitric oxide is also increased in the lower respiratory tract after HSCT (123). Potential sources of nitric oxide are chemotherapy-induced inflammation of lung epithelium and lung-infiltrating inflammatory cells (118).…”

Section: Oxidative Stress and Pulmonary Dysfunction During Ipsmentioning

confidence: 99%

An Official American Thoracic Society Research Statement: Noninfectious Lung Injury after Hematopoietic Stem Cell Transplantation: Idiopathic Pneumonia Syndrome

Panoskaltsis‐Mortari¹,

Griese²,

Madtes³

et al. 2011

Am J Respir Crit Care Med

274

308

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IPS remains a frequently fatal complication that limits the broader use of allogeneic HSCT as a successful treatment modality. Faced with the clinical syndrome of IPS, one can categorize the disease entity with the appropriate tools, although cases of unclassifiable IPS will remain. Significant research efforts have resulted in a paradigm shift away from identifying noninfectious lung injury after HSCT solely as an idiopathic clinical syndrome and toward understanding IPS as a process involving aspects of both the adaptive and the innate immune response. Importantly, new laboratory insights are currently being translated to the clinic and will likely prove important to the development of future strategies to prevent or treat this serious disorder.

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“…Another report studying FeNO in patients after autologous HSCT is that of Qureshi et al [ 19 ]. In their study, FeNO was significantly increased following autologous peripheral HSCT and correlated with reduction in DLCO.…”

Section: Discussionmentioning

confidence: 99%

Is It Possible to Predict Pulmonary Complications and Mortality in Hematopoietic Stem Cell Transplantation Recipients from Pre-Transplantation Exhaled Nitric Oxide Levels?

Köktürk¹,

Yıldırım

Aydoğdu³

et al. 2016

Tjh

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Objective:Chemo/radiotherapy-induced free oxygen radicals and reactive oxygen derivatives contribute to the development of early and late transplantation-related pulmonary and extra-pulmonary complications in hematopoietic stem cell transplantation (HSCT) recipients. It has been proposed that an increase in fractional exhaled nitric oxide (FeNO) level indicates oxidative stress and inflammation in the airways. The aim of this prospective study is to evaluate the pre-transplantation FeNO levels in HSCT patients and to search for its role in predicting post-transplantation pulmonary complications and mortality.Materials and Methods:HSCT patients were included in the study prospectively between October 2009 and July 2011. Pre-transplantation FeNO levels were measured with a NIOX MINO® device prior to conditioning regimens. All patients were monitored prospectively for post-transplantation pulmonary complications with medical history, physical examination, chest X-ray, and pulmonary function tests.Results:A total of 56 patients (33 autologous, 23 allogeneic) with mean age of 45±13 years were included in the study, among whom 40 (71%) were male. Pre-transplantation FeNO level of the whole study group was found to be 24±13 (mean ± standard deviation) parts per billion (ppb). The FeNO level in allogeneic HSCT recipients was 19±6 ppb while it was 27±15 ppb in autologous HSCT recipients (p=0.042). No significant correlation was found between the pre-transplantation chemotherapy and radiotherapy protocols and baseline FeNO levels (p>0.05). Post-transplantation pulmonary toxicity was identified in 12 (21%) patients and no significant relationship was found between baseline FeNO levels and pulmonary toxicity. The survival rate of the whole study group for 1 year after transplantation was 70%. No significant relationship was identified between baseline FeNO values and survival (FeNO 19±7 ppb in patients who died and 26±15 ppb in the survivors; p=0.114).Conclusion:Pre-transplantation FeNO measurement does not seem to have a role in predicting post-transplantation pulmonary complications and mortality.

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Increased Exhaled Nitric Oxide Following Autologous Peripheral Hematopoietic Stem-Cell Transplantation

Cited by 13 publications

References 45 publications

Exhaled nitric oxide and pulmonary complications after paediatric stem cell transplantation

Exhaled nitric oxide and pulmonary complications after paediatric stem cell transplantation

An Official American Thoracic Society Research Statement: Noninfectious Lung Injury after Hematopoietic Stem Cell Transplantation: Idiopathic Pneumonia Syndrome

Is It Possible to Predict Pulmonary Complications and Mortality in Hematopoietic Stem Cell Transplantation Recipients from Pre-Transplantation Exhaled Nitric Oxide Levels?

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