Increased excretion of collagen crosslinks in irradiated patients indicates destruction of collagen

Abstract

The urinary excretion of HP and LP was increased directly after a course of RT. This finding may reflect either destruction of collagen or increased bone remodeling/resorption after radiotherapy. Either way these findings suggest a relation to the mechanical instability of bone directly after radiotherapy. Future investigations of irradiated patients without osseous metastases will further clarify this matter.

Local irradiation alters bone morphology and increases bone fragility in a mouse model

“…It is further possible that there are changes to the collagen structure post-irradiation. This concept is supported by urine analysis in humans following radiation therapy (Niehoff et al, 2006), which showed increased hydroxylysylpyridinoline and lysyl pryridinoline collagen crosslinks excretion. There are several limitations to this study.…”

Proof of Direct Radiogenic Destruction of Collagen in Vitro

“…This might be a possible effect of a direct radiogenic damage of collagen and extracellular matrix during radiotherapy [25].…”

The cytotoxic effects of three different bisphosphonates in-vitro on human gingival fibroblasts, osteoblasts and osteogenic sarcoma cells

“…Execution followed as previously described (Jamall et al, 1981;Açil and Müller, 1994;Acil et al, 2000Acil et al, , 2002Acil et al, , 2005Niehoff et al, 2006;Acil et al, 2007).…”