Increased epicardial adipose tissue thickness correlates with endothelial dysfunction in spondyloarthritis

Tekaya, A. Ben; Mehmli, T.; Mrad, Imtinene Ben; Fendri, Ahmed; Boukriba, Seif; Bouden, S.; Rouached, L.; Tekaya, R.; Saidane, O.; Mahmoud, I.; Abdelmoula, L.

doi:10.1007/s10067-022-06261-5

Cited by 5 publications

(5 citation statements)

References 44 publications

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“…EAT is the visceral fat between the myocardium and pericardium, covering 80% of the heart surface[ 10 ]. The EAT is supplied by the coronary artery.…”

Section: Discussionmentioning

confidence: 99%

Early diagnostic value of carotid artery ultrasound parameters combined with epicardial adipose layer thickness in coronary heart disease

Xu,

2024

World J Clin Cases

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BACKGROUND Coronary heart disease is associated with coronary atherosclerosis indicated by carotid intima-media thickness (CIMT) thickening and altered vascular elasticity. The epicardial adipose layer can secrete proinflammatory factors that promote the formation of coronary atherosclerosis. Thus, the epicardial fat layer thickness (EAT) may also predict coronary heart disease. AIM To determine the role of common carotid artery ultrasound parameters and EAT in the early diagnosis of coronary artery disease. METHODS Based on coronary angiography, patients with newly suspected coronary heart disease were divided into case (n = 107) and control (n = 41) groups. The carotid ultrasound parameters, including vascular stiffness (β), elastic coefficient (EP), pulse wave conduction velocity (PWV-β), CIMT, and EAT were compared between the case and control groups and among patients with different lesion numbers in the case group. Pearson correlation was used to evaluate the early diagnostic value of EAT, common carotid artery elasticity, and CIMT for coronary heart disease. RESULTS EP, β, PWV-β, CIMT, and EAT were significantly higher in the case group compared with the levels in the control group (all P < 0.001). In the case group, lesions were detected in one vessel in 34 patients, two vessels in 38 patients, and three vessels in 35 patients. Within the case group, β, EP, PWV-β, CIMT, and EAT levels significantly increased with an increased number of lesions (all P < 0.001). EAT positively correlated with β, EP, PWV-β, and CIMT (all P < 0.01). The area under the curve for diagnosing coronary heart disease using EAT combined with CIMT and carotid elasticity was 0.893, and the sensitivity and specificity were 0.890 and 0.837. CONCLUSION EAT correlated well with changes in carotid artery elasticity and CIMT in patients with coronary heart disease. The combination of EAT, carotid artery elasticity, and CIMT facilitates the early diagnosis of coronary heart disease.

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“…EAT is the visceral fat between the myocardium and pericardium, covering 80% of the heart surface[ 10 ]. The EAT is supplied by the coronary artery.…”

Section: Discussionmentioning

confidence: 99%

Early diagnostic value of carotid artery ultrasound parameters combined with epicardial adipose layer thickness in coronary heart disease

Xu,

2024

World J Clin Cases

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“…Another age-and sex-matched cross-sectional study, including 76 patients with RA and 50 controls, reported a greater EAD thickness in RA patients (26,27). Increased EAD thickness is associated with endothelial dysfunction in spondyloarthritis (28). It suggests that EAD thickness is a candidate for atherosclerotic risk assessment in patients with systemic sclerosis without open heart disease (29).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Epicardial Fat Thickness, a New Indicator of the Cardiovascular Risk Factor, in Patients With Systemic Lupus Erythematosus

Hakbilen,

Yılmaz,

Özer

et al. 2023

qrheumatol

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Aim: Aim: Systemic lupus erythematosus (SLE) is a chronic autoimmune rheumatic disease with high cardiovascular mortality. Epicardial adipose tissue (EAD) is the visceral fat located between the myocardium and pericardium. EAD is recognized as an active metabolic and inflammatory tissue capable of producing and releasing various preatherosclerotic and proinflammatory hormones, cytokines. EAD is associated with coronary artery disease, metabolic syndrome, and subclinical atherosclerosis. In this study, we investigated the relationship between EAD and SLE patients. Material and Methods:Material and Methods: A total of 73 patients were recruited from the rheumatology department of a single center as a case-control study. The participants were divided into two groups: 73 patients with SLE (group 1) and 60 age-and sex-matched controls (group 2). Laboratory and radiological results were obtained from the electronic registration database. Data were analyzed and compared between the groups.Results: Results: There was no significant difference between the groups in terms of age, gender, height, weight, or body mass index (BMI). EAD was found to be significantly higher in SLE patients than in the control group. In the SLE group, EAD was found to be significantly higher in patients with low complement levels than in those without. There was a positive correlation between EAD and age, leukocytes, neutrophils, C-reactive protein (CRP), and BMI, but a negative correlation was found between SLE disease activity index. Conclusion: Conclusion:Increased EAD was found in SLE patients compared with the control group. In addition, a correlation was found between increased EAD and low complement and CRP. EAD may be a measurable and modifiable potential therapeutic target associated with inflammation and cardiovascular risk in patients with SLE.

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“…A recent study showed that patients with severe coronary atherosclerosis, glucose and insulin metabolic disorder, and serum adiponectin reduction are significantly linked with higher oxidative stress in EAT adipocytes ( 60 ). In addition, EAT thickness was related with endothelial dysfunction ( 61 ), and it was concluded that EAT may predict the early reversible stages of atherosclerosis. The data from different studies showed that increased EAT volume is involved in high-risk coronary plaque formation.…”

Section: Epicardial Adipose Tissue: a New Biomarker For Cardiovascula...mentioning

confidence: 99%

The role of epicardial adipose tissue dysfunction in cardiovascular diseases: an overview of pathophysiology, evaluation, and management

Liu

Adhikari³

et al. 2023

Front. Endocrinol.

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In recent decades, the epicardial adipose tissue (EAT) has been at the forefront of scientific research because of its diverse role in the pathogenesis of cardiovascular diseases (CVDs). EAT lies between the myocardium and the visceral pericardium. The same microcirculation exists both in the epicardial fat and the myocardium. Under physiological circumstances, EAT serves as cushion and protects coronary arteries and myocardium from violent distortion and impact. In addition, EAT acts as an energy lipid source, thermoregulator, and endocrine organ. Under pathological conditions, EAT dysfunction promotes various CVDs progression in several ways. It seems that various secretions of the epicardial fat are responsible for myocardial metabolic disturbances and, finally, leads to CVDs. Therefore, EAT might be an early predictor of CVDs. Furthermore, different non-invasive imaging techniques have been proposed to identify and assess EAT as an important parameter to stratify the CVD risk. We also present the potential therapeutic possibilities aiming at modifying the function of EAT. This paper aims to provide overview of the potential role of EAT in CVDs, discuss different imaging techniques to assess EAT, and provide potential therapeutic options for EAT. Hence, EAT may represent as a potential predictor and a novel therapeutic target for management of CVDs in the future.

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Increased epicardial adipose tissue thickness correlates with endothelial dysfunction in spondyloarthritis

Cited by 5 publications

References 44 publications

Early diagnostic value of carotid artery ultrasound parameters combined with epicardial adipose layer thickness in coronary heart disease

Early diagnostic value of carotid artery ultrasound parameters combined with epicardial adipose layer thickness in coronary heart disease

Evaluation of Epicardial Fat Thickness, a New Indicator of the Cardiovascular Risk Factor, in Patients With Systemic Lupus Erythematosus

The role of epicardial adipose tissue dysfunction in cardiovascular diseases: an overview of pathophysiology, evaluation, and management

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