Increased Endothelin-1 Levels of BAL Fluid in Patients with Behçet's Disease

Hamzaoui, Kamel; Chelbi, Hanene; Kamoun, M.; Dhifallah, Imen Ben; Hamzaoui, A.

doi:10.1155/2007/93726

Cited by 4 publications

(6 citation statements)

References 32 publications

(36 reference statements)

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“…These observations are supported by other studies as well. [ 23 22 14 9 ] It is not known whether elevated ET-1 levels are a direct result of its increased synthesis from injured vascular endothelial cells or whether its high concentrations may be responsible, along with other factors, for both vascular and articular complications in patients with BD. [ 22 ] One study attributed the increase of serum ET-1 levels in BD to increased secretion or leakage of this mitogen from injured vascular endothelial cells.…”

Section: Discussionmentioning

confidence: 99%

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Assessment of serum homocysteine, endothelin-1, and nitric oxide levels in behçet′s disease

2010

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Background:Some prominent features of Behçet’s disease (BD) are arterial and venous thromboses as a result of endothelial dysfunction. Hyperhomocysteinemia is responsible for vascular endothelial injury due to an increased frequency of thrombogenesis. Endothelin-1 (ET-1) is a vasoconstrictor whereas nitric oxide (NO) is an endothelial vasorelaxing peptide that is responsible for the inhibition of platelet adhesion.Aim:To evaluate serum levels of homocysteine (Hcy) and determine whether hyperhomocysteinemia is considered as a contributing risk factor for venous and arterial thromboses of BD, and to correlate serum levels of ET-1 and NO with disease activity.Materials and Methods:We measured serum levels of Hcy, ET-1, and nitrite (NO2−) in 25 patients who fulfilled the criteria of the International Study Group for BD, and compared them to those of 15 healthy control subjects. Levels of Hcy and ET-1 were measured by using enzyme-linked immunosorbent assay (ELISA), whereas serum nitrite (NO2−) levels were measured by using Griess reaction as an indicator for NO production. All the patients were screened for a history of venous thrombosis and subdivided into thrombotic and nonthrombotic subgroups according to their thrombotic history. Patients with BD were divided into two subgroups, active and inactive, according to their clinical and laboratory findings.Results:There were significant increases in serum levels of Hcy, ET-1, and nitrite in BD patients compared to those in controls. There was a significant increase in serum Hcy levels in thrombotic compared to nonthrombotic subgroups. Positive correlations were detected between the serum ET-1 and nitrite levels with disease activity in BD patients.Conclusion:Hyperhomocysteinemia may play some role in the development of venous and arterial thromboses in BD. Increased NO production might ave critical biological activities that are relevant to pathological events in the active period of the disease.

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Section: Discussionmentioning

confidence: 99%

“…[ 8 ] Overexpression of proinflammatory cytokines, adhesion molecules, free oxygen radicals, and high homocysteine levels have been suggested to be responsible for the activation of endothelial cells, irrespective of overt vascular manifestations. [ 9 ]…”

Section: Introductionmentioning

confidence: 99%

Assessment of serum homocysteine, endothelin-1, and nitric oxide levels in behçet′s disease

2010

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“…De plus, il a été prouvé que la pathogénie de la vascularite est liée de faç on complexe à l'angiogenèse et implique une surexpression des facteurs de croissance angiogé-niques comme le VEGF, la MCP-1, le facteur de croissance dérivé des plaquettes, le facteur de croissance des fibroblastes (FGF) et le facteur de croissance transformant [4]. Plusieurs études ont montré que les facteurs angiogéniques comme le VEGF, la MCP-1 et l'endothéline-1 sont significativement augmentés chez les patients MB, particulièrement ceux dont la maladie est active [5][6][7][8][9], même si ces résultats ne sont pas toujours en accord avec ceux d'autres études [7,9]. Sur la base de précédentes études concernant les facteurs angiogéniques dans la MB, l'angiogénèse pourrait être le mécanisme pathogénique primaire de la MB.…”

Section: Discussionunclassified

“…[5][6][7], la protéine chimioattractive monocytaire 1 (MCP-1) [6] et l'endothéline-1 dans le liquide de lavage bronchoalvéolaire (LBA) [8,9] étaient significativement augmentés chez les patients atteints de MB en comparaison aux patients témoins. Cependant, les taux sériques de base de facteur de croissance des fibroblastes (bFGF) [7] et d'endothéline-1 sérique [9] n'étaient pas significativement différents entre les patients MB et les patients témoins.…”

Section: Introductionunclassified

Le taux sérique d’angiopoïétine-1 est augmenté chez les patients atteints de maladie de Behçet

Choe¹,

Park²,

Kim³

2010

Revue du Rhumatisme

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“…In the presence of antigens and mitogens, VEGF can induce Th1 polarization (21), which is observed during the active stage of BD (22). VEGF also induces a variety of proinflammatory changes in chronic inflammation, including leucocyte accumulation, collagen deposition and blood vessel alterations (23, 24). A recognized stimulus for VEGF production is inflammation.…”

Section: Clinical Characteristics Of Patients With Behçet’s Disease Amentioning

confidence: 99%

Vascular endothelial growth factor gene polymorphisms and serum levels in Behçet’s disease

et al. 2008

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Vascular endothelial growth factor (VEGF) is important for angiogenesis and inflammation, both of which are codependent and contribute to the pathophysiology of Behçet's disease (BD). In this report, we sought to investigate whether the selected VEGF polymorphisms [-634 C/G, +936 C/T and an 18 bp insertion/deletion (I/D) at -2549 of the VEGF promoter region] are associated with susceptibility and severity of BD in the Tunisian population. One hundred and thirty-five Tunisian BD patients and 157 healthy controls were recruited. The VEGF gene was genotyped by polymerase chain reaction followed by digestion with restriction endonucleases. VEGF serum levels of BD patients and healthy controls were measured by enzyme-linked immunosorbent assay. We found no association between the VEGF polymorphisms and the susceptibility to BD. However, when data were analysed according to the presence of each symptom, we found a positive association between VEGF 18 bp I/D polymorphism and ocular involvement as well as BD severity. Indeed, among the BD patients, the frequency of the 18 bp I/I genotype was less in patients with ocular inflammation (6.1% vs 24.6%, P = 0.007) and in patients with severe BD (9.2% vs 21.4%, P = 0.0014). Moreover, the mean serum VEGF level was considerably higher in BD patients (P < 0.01) than in healthy controls. We suggest that VEGF gene polymorphisms may be involved in the development of the ocular BD as well as the severity of the disease.

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Increased Endothelin-1 Levels of BAL Fluid in Patients with Behçet's Disease

Cited by 4 publications

References 32 publications

Assessment of serum homocysteine, endothelin-1, and nitric oxide levels in behçet′s disease

Assessment of serum homocysteine, endothelin-1, and nitric oxide levels in behçet′s disease

Le taux sérique d’angiopoïétine-1 est augmenté chez les patients atteints de maladie de Behçet

Vascular endothelial growth factor gene polymorphisms and serum levels in Behçet’s disease

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