Increased endometrial thickness is associated with improved treatment outcome for selected patients undergoing in vitro fertilization–embryo transfer

Zhang, Xingqi; Chen, Chi Huang; Confino, Edmond; Barnes, Randall B.; Milad, Magdy P.; Kazer, Ralph R.

doi:10.1016/j.fertnstert.2004.09.020

Cited by 152 publications

(121 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The high oxygen concentrations near the basal layer could be detrimental compared with the usual low oxygen tension of the surface endometrium [6]. In a more recent study, clinical pregnancy was found to be positively associated with increased endometrial thickness and negatively associated with advanced age [7]. In our study, women with the distinct five-line appearance of the endometrium showed a higher pregnancy rate compared to that of hazy five-line appearance.…”

Section: Discussionmentioning

confidence: 37%

Ultrasonography and Doppler Study to Predict Uterine Receptivity in Infertile Patients Undergoing Embryo Transfer

Khan¹,

Shaikh²,

Ratnani³

2015

J Obstet Gynecol India

View full text Add to dashboard Cite

About the Author AbstractPurpose To detect whether ultrasonographic parameters and Doppler analysis of uterine blood flow can be of value in the prediction of endometrial receptivity in infertile female patients undergoing embryo transfer. Methods In this study, a total of 200 women with primary infertility undergoing embryo transfer were analyzed. Transvaginal ultrasonography was done on the 10th day of the menstrual cycle. To assess the uterine receptivity, we analyzed all the ultrasonographic and Doppler parameters. The slightly modified version of Applebaum Uterine Scoring System was used. This uterine scoring system included all the following parameters: endometrial thickness, endometrial morphology, endometrial blood flow within zone 3, myometrial echogenecity, uterine artery pulsatility index (PI), end diastolic blood flow, and myometrial blood flow internal to the arcuate vessels seen on gray-scale examination. Results The pregnancy rates were higher in women with thick, distinct five-line endometrium and multifocal endometrial vascularity within zone 3. Absent endometrial flow, despite highest values for the other parameters, was associated with no conception. In our study, no pregnancy occurred with uterine PI values of more than 2.8. Absence or reversal of end diastolic blood flow was associated with no conception. A maximum score of 20 was associated with the pregnancy rate of 97.4 %, whereas scores of 13 or less resulted in no pregnancies. 123Conclusion Uterine scoring system will help to perform embryo transfers in only favorable uteri and postpone or cancel those cycles in which poor uterine score is demonstrated.

show abstract

Section: Discussionmentioning

confidence: 37%

Ultrasonography and Doppler Study to Predict Uterine Receptivity in Infertile Patients Undergoing Embryo Transfer

Khan¹,

Shaikh²,

Ratnani³

2015

J Obstet Gynecol India

View full text Add to dashboard Cite

show abstract

“…Endometrial thickness has been reported to be one of the most important factors for success in ART. Zhang et al [12] reported a significant difference in the pregnancy rate in patients with an endometrial thickness above and below 9 mm, whereas Kovacs et al [13] and Richter et al [14] showed a gradual increase in the implantation rate with increasing endometrial thickness. In the present study, none of the patients whose endometrial thickness was <7 mm achieved a live-birth (data not shown).…”

Section: Discussionmentioning

confidence: 98%

The outcome of infertility treatment in patients undergoing assisted reproductive technology after conservative therapy for endometrial cancer

Fujimoto

Ichinose

Harada

et al. 2014

J Assist Reprod Genet

View full text Add to dashboard Cite

Purpose To elucidate the problems in infertility treatment for women after conservative therapy for endometrial cancer (EC) or atypical complex endometrial hyperplasia (ACEH). Methods The clinical outcomes of 21 patients who underwent assisted reproductive technology after conservative therapy (group A) and 42 control women (group B) were retrospectively analyzed. Results There was no significant difference in the number of retrieved oocytes, fertilization rate or the number of transferred embryos between the two groups. Women in group A had a significantly thinner endometrium and a reduced implantation rate compared to those for women in group B. There was no significant difference in the cumulative clinical pregnancy and delivery rates between group A and B. The patients in group A required significantly more embryos for achieving a live-birth. Conclusions Our results indicate that a thin endometrium after repeated curettage may have a negative effect on endometrial receptivity of patients after conservative treatment for EC/ACEH. Clinicians should reconsider their present protocols and make efforts to minimize the damage to normal endometrium.

show abstract

“…Despite the existence of quite a few published studies, the prognostic value of ultrasonographic endometrial thickness measurements (and other parameters) in predicting implantation and pregnancy rates remains controversial. Some investigators have demonstrated a positive correlation between endometrial thickness and pregnancy rates [1][2][3][4][5][6][7][8]11] while others have not found such an association [9,10,[12][13][14], or only in association with other parameters [15,16]. However, these differences may be in part attributed to different patient populations, stimulation protocols used or measurement timing.…”

Section: Discussionmentioning

confidence: 99%

“…While some studies have shown that this parameter is important for predicting the outcome of In Vitro Fertilization (IVF) cycles [1][2][3][4][5][6][7][8], other studies have failed to show such a positive relationship [9][10][11][12][13][14]. In a third category of studies the endometrial thickness was related to the IVF outcome, but only in correlation with other parameters [15,16]. Different thresholds of endometrial thickness were suggested as essential for successful implantation and most demonstrated that no pregnancy was established when the thickness of the pre-ovulatory endometrium was <6 mm [17].…”

Section: Introductionmentioning

confidence: 99%

Thin unresponsive endometrium—a possible complication of surgical curettage compromising ART outcome

Shufaro

Simon

Laufer

et al. 2008

J Assist Reprod Genet

View full text Add to dashboard Cite

Purpose Endometrial thickness is important for implantation. Little data addresses the etiology of persistently thin endometrium. We present a patient cohort in order to define common features and draw conclusions. Methods Thirteen out of 1,405 IVF patients repeatedly had thin unresponsive endometrium (<7 mm). Age, history, uterine cavity status, treatment type and outcome were examined. Results Patient age was 35.9±5.7 years. Ten patients had a curettage performed previously. Nine patients had normal cavity and endometrium, and in four adhesions were diagnosed and removed. Out of 99 cycles performed afterwards, endometrial thickness increased in 22. ETs were performed in 49 cycles resulting in 11 pregnancies. Their outcome was eight miscarriages, two terminations due to malformations, and one live birth. Conclusions Thin unresponsive endometrium was associated with curettage, not necessarily with intrauterine adhesions. Even if adequate thickening eventually occurred, the reproductive outcome was still very poor. Therefore other alternatives should be sought for these patients.

show abstract

Increased endometrial thickness is associated with improved treatment outcome for selected patients undergoing in vitro fertilization–embryo transfer

Cited by 152 publications

References 16 publications

Ultrasonography and Doppler Study to Predict Uterine Receptivity in Infertile Patients Undergoing Embryo Transfer

Ultrasonography and Doppler Study to Predict Uterine Receptivity in Infertile Patients Undergoing Embryo Transfer

The outcome of infertility treatment in patients undergoing assisted reproductive technology after conservative therapy for endometrial cancer

Thin unresponsive endometrium—a possible complication of surgical curettage compromising ART outcome

Contact Info

Product

Resources

About