Increased duration of illness is associated with reduced volume in right medial temporal/anterior cingulate grey matter in patients with chronic schizophrenia

Velakoulis, Dennis; Wood, Stephen J.; Smith, Deidre J.; Soulsby, Bridget; Brewer, Warrick J.; Leeton, L.; Desmond, Patricia; Suckling, John; Bullmore, Edward T.; McGuire, Philip; Pantelis, Christos

doi:10.1016/s0920-9964(01)00307-3

Cited by 82 publications

(41 citation statements)

References 21 publications

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“…The association between longer duration of illness and lower GM volume and CSF excess in the cerebellum is consistent with an earlier report of an association between longer duration of illness and cerebellar GM volume using VBM in chronic patients [25], though it was not observed using the ROI approach in our previous study [16]. It is possible that the duration of illness effect may be localised to specific regions within the cerebellum.…”

supporting

confidence: 92%

“…One study [24] of 20 schizophrenia patients (mean age = 37 years, median duration of illness = 15 years [2-41 years]) did not observe any association between duration of illness and GM volume across the brain. Another study [25] (n = 39) reported (mean age = 36 years, median duration of illness = 11 years [2-31 years]) an inverse association between duration of illness and GM volume in the medial temporal lobe, cerebellum and the anterior cingulate gyrus, but not in the frontal lobe.…”

mentioning

confidence: 99%

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Association between a longer duration of illness, age and lower frontal lobe grey matter volume in schizophrenia

Premkumar

Fannon

Kuipers

et al. 2008

Behavioural Brain Research

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P r e -P r i n t AbstractThe frontal lobe has an extended maturation period and may be vulnerable to the long-term effects of schizophrenia. We tested this hypothesis by studying the relationship between duration of illness (Dol) and grey matter (GM) volume across the whole brain. Sixty-four patients with schizophrenia and 25 healthy controls underwent structural MRI scanning and neuropsychological assessment. We performed regression analyses in patients to examine the relationship between Dol and GM and cerebro-spinal fluid (CSF) volumes across the whole brain, and correlations in controls between age and GM or CSF volume of the regions where GM or CSF volumes were associated with Dol in patients. Correlations were also performed between GM volume in the regions associated with Dol and neuropsychological performance.A longer Dol was associated with lower GM volume in the left dorsomedial prefrontal cortex (PFC), right middle frontal cortex, left fusiform gyrus (FG) and left cerebellum (lobule III).Additionally, age was inversely associated with GM volume in the left dorsomedial PFC in patients, and in the left FG and CSF excess near the left cerebellum in healthy controls.Greater GM volume in the left dorsomedial PFC was associated with better working memory, attention and psychomotor speed in patients. Our findings suggest that the right middle frontal cortex is particularly vulnerable to the long-term effect of schizophrenia illness whereas the dorsomedial PFC, FG and cerebellum are affected by both a long Dol and aging. The effect of illness chronicity on GM volume in the left dorsomedial PFC may be extended to brain structureneuropsychological function relationships. 2

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supporting

confidence: 92%

mentioning

confidence: 99%

Association between a longer duration of illness, age and lower frontal lobe grey matter volume in schizophrenia

Premkumar

Fannon

Kuipers

et al. 2008

Behavioural Brain Research

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“…These findings allow the possibility that the right temporal MRI changes in elderly patients with schizophrenia are the outcome of long-term slow progressive changes which outlast those on the left which mediate transition to psychosis. This is similar to the suggestion of Velakoulis et al (2002), which focuses on the left and right hippocampi.…”

Section: Discussionsupporting

confidence: 91%

Right-hemisphere encephalopathy in elderly subjects with schizophrenia: evidence from neuropsychological and brain imaging studies

Gabrovska-Johnson

Scott²,

Jeffries

et al. 2003

Psychopharmacology

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“…The temporal lobe has been reported to have highly neural connectivity with prefrontal lobe (Walterfang et al 2006;Vernooij et al 2007). Many previous studies reported anatomical deficits in frontotemporal cortices in schizophrenia, such as progressive gray matter volume reduction in the left ventral prefrontal cortex, both side middle frontal gyri, right inferior temporal cortex, both side middle and superior temporal gyri (Velakoulis et al 2002;Pantelis et al 2003;Whitford et al 2006;Mitelman and Buchabaum 2007). Multiple diffusion tensor imaging (DTI) studies found significantly reduced white matter integrity in the left side uncinate fasciculus in schizophrenia (Burns et al 2003;Kubicki et al 2002), a structure that is one of the major pathways directly connecting frontal and superior temporal gyri.…”

Section: Discussionmentioning

confidence: 99%

Disturbed Functional Connectivity of Cortical Activation during Semantic Discrimination in Patients with Schizophrenia and Subjects at Genetic High-risk

Branch

Nierenberg

et al. 2010

Brain Imaging and Behavior

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Schizophrenia has a strong genetic component that is relevant to the understanding of the pathophysiology of the syndrome. Thus, recent investigations have shifted from studies of diagnosed patients with schizophrenia to examining their unaffected relatives. Previous studies found that during language processing, relatives thought to be at genetic high-risk for the disorder exhibit aberrant functional activation in regions of language processing, specifically in the left inferior frontal gyrus (Broca's area). However, functional connectivity among the regions involved in language pathways is not well understood. In this study, we examined the functional connectivity between a seed located in Broca's area and the remainder of the brain during a visual lexical decision task, in 20 schizophrenia patients, 21 subjects at genetic high risk for the disorder and 21 healthy controls. Both the high-risk subjects and patients showed significantly reduced activation correlations between seed and regions related to visual language processing. Compared to the high-risk subjects, the schizophrenia patients showed even fewer regions that were correlated with the seed regions. These results suggest that there is aberrant functional connectivity within cortical language circuitry in high-risk subjects and patients with schizophrenia. Broca's area, which is one of the important regions for language processing in healthy controls, had a significantly reduced role in the high-risk subjects and patients with schizophrenia. Our findings are consistent with the existence of an underlying biological disturbance that begins in genetically at risk individuals and progresses to a greater extent in those who eventually develop schizophrenia.

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Increased duration of illness is associated with reduced volume in right medial temporal/anterior cingulate grey matter in patients with chronic schizophrenia

Cited by 82 publications

References 21 publications

Association between a longer duration of illness, age and lower frontal lobe grey matter volume in schizophrenia

Association between a longer duration of illness, age and lower frontal lobe grey matter volume in schizophrenia

Right-hemisphere encephalopathy in elderly subjects with schizophrenia: evidence from neuropsychological and brain imaging studies

Disturbed Functional Connectivity of Cortical Activation during Semantic Discrimination in Patients with Schizophrenia and Subjects at Genetic High-risk

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