Increased Dopamine Is Associated With the cGMP and Homocysteine Pathway in Female Migraineurs

Gruber, Hans-Jürgen; Bernecker, Claudia; Pailer, Sabine; Lechner, Anita; Horejsi, Renate; Möller, Reinhard; Fazekas, Franz; Truschnig-Wilders, M.

doi:10.1111/j.1526-4610.2009.01533.x

Cited by 7 publications

(9 citation statements)

References 46 publications

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“…Among the included papers, 22 articles compared serum homocysteine levels in migraine patients and HC, 53‐74 13 articles compared serum cobalamin levels in migraine patients and HC, 56,57,63,65,66,68‐70,73,75‐78 and 13 articles compared serum folate levels in migraine patients and HC 56,57,63‐66,68‐70,73,77‐79 (Table 1). Moreover, 13 studies compared serum homocysteine levels in MA and MO patients, 54,55,57,59‐61,64,67,68,73,74,80,81 4 studies compared serum cobalamin levels in MA and MO patients, 57,68,73,77 and 5 studies compared serum folate levels in MA and MO patients 57,64,68,73,77 (Table 2).…”

Section: Resultsmentioning

confidence: 99%

“…No study evaluating serum pyridoxine was retrieved. Regarding age distribution, 19 studies involved adults, 53,55‐57,59‐61,63,64,66,68,70‐72,75,77‐80 3 studies involved children (<18 years), 54,65,76 2 studies involved both adults and non‐adult participants older than 14 62 and 15 years 58 (they were conventionally analyzed along with the adult population), and 5 studies did not present any age information 67,69,73,74,81…”

Section: Resultsmentioning

confidence: 99%

“…Bottini et al was the sole article that reported the recruitment of children and determined lower folate levels [SMD = −0.71, 95%CI = (−1.14, −0.29) in migraine patients (n = 45) in comparison with HC (n = 45) 65 . There were 2 conference abstracts that did not specify the age groups, 69,73 while the rest 8 studies enrolled adult patients 56,57,63,68,70,77‐79 . Adult migraine patients (n = 643) registered marginally insignificant lower folate levels than HC (n = 572) [ P Q = .39, I 2 = 6%, RE‐SMD = −0.11, 95%CI = (−0.23, 0.01)].…”

Section: Resultsmentioning

confidence: 99%

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Serum Homocysteine, Pyridoxine, Folate, and Vitamin B12 Levels in Migraine: Systematic Review and Meta‐Analysis

et al. 2020

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Background Migraine, especially migraine with aura (MA), has been linked to increased risk for ischemic cerebrovascular disease. The possible role of elevated serum homocysteine (Hcy, a cause of thrombophilia) in migraine has been demonstrated by several studies. Objective The present study aims to review and meta‐analyze data from studies investigating the difference of serum Hcy and Hcy lowering vitamins between migraine patients and healthy controls (HC), as well as between patients with MA and migraine without aura (MO). Methods Literature search involved MEDLINE, Embase, CENTRAL, Google Scholar, and trial registries. The Newcastle‐Ottawa Scale was used to evaluate the quality of the retrieved studies. Standardized mean differences (SMDs) and 95% confidence intervals (95%CIs) were calculated. Funnel‐plots were utilized for the evaluation of publication bias. Results Overall, 29 (28 case‐control and 1 cross‐sectional) studies were retrieved. Meta‐analysis was indicative of higher Hcy concentration in migraine patients vs HC overall [adults and children: 16 studies, I2 = 81%, SMD = 0.41, 95%CI = (0.20, 0.61)]. Hcy was consistently elevated in adults with migraine [adults: 12 studies, I2 = 76%, SMD = 0.35, 95%CI = (0.15, 0.54); children: 1 study, SMD = 0.37, 95%CI = (−0.05, 0.79)]. Subgroup analyses reproduced the results for both adults with MA [7 studies, I2 = 83%, SMD = 0.37, 95%CI = (0.03, 0.71)] and MO [5 studies, I2 = 84%, SMD = 0.46, 95%CI = (0.03, 0.89)]. Figures for serum folate were lower in the overall comparison of migraine patients with HC [adults and children: 11 studies, I2 = 87%, SMD = −0.36, 95%CI = (−0.68, −0.05); adults: 8 studies, I2 = 6%, SMD = −0.11, 95%CI = (−0.22, 0.01); children: 1 study, SMD = −0.71, 95%CI = (−1.14, −0.29); MA adults: 4 studies, I2 = 44%, SMD = −0.16, 95%CI = (−0.35, 0.04); MO adults: 4 studies, I2 = 47%, SMD = −0.17, 95%CI = (−0.44, 0.10)]. Serum vitamin B12 levels were not different between migraine patients and HC [adults and children: 11 studies, I2 = 88%, SMD = −0.24, 95%CI = (−0.57, 0.09); adults: 8 studies, I2 = 57%, SMD = −0.10, 95%CI = (−0.28, 0.08); children: 1 study, SMD = 0.29, 95%CI = (−0.13, 0.71); MA adults: 4 studies, I2 = 63%, SMD = −0.14, 95%CI = (−0.48, 0.20); MO adults: 4 studies, I2 = 59%, SMD = −0.15, 95%CI = (−0.45, 0.15)]. Serum Hcy was lower in MO than MA [adults and children: 10 studies, I2 = 39%, SMD = 0.30, 95%CI = (0.14, 0.46), adults: 6 studies, I2 = 29%, SMD = 0.21, 95%CI = (0.09, 0.36), children: 1 study, SMD = 0.51, 95%CI = (0.22, 0.80)]. Serum folate and vitamin B12 did not differ between MA and MO. Conclusions Our results suggest that there is a possible link between migraine, mainly MA, and elevated serum Hcy.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Serum Homocysteine, Pyridoxine, Folate, and Vitamin B12 Levels in Migraine: Systematic Review and Meta‐Analysis

et al. 2020

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“…Three studies on urinary NOx demonstrated more than double concentrations in patients with respect to controls (13,30,46), but one conducted only in females gave opposite results (14). Consequently, the summary estimate showed no difference (Table 2).…”

Section: Resultsmentioning

confidence: 99%

A meta-analysis of biomarkers related to oxidative stress and nitric oxide pathway in migraine

et al. 2015

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“…The DA metabolite 3,4-dihydroxyphenylacetic acid (DOPAC) increases in CSF during the migraine attack and increased levels correlate with pain severity [10]. Increased DA urinary levels have been described in female but not in male migraineurs during the headache-free period [11]. DA levels in platelets are higher in migraine patients than in controls but only in migraine without aura [12].…”

Section: Biochemistrymentioning

confidence: 99%

Dopaminergic symptoms in migraine

et al. 2013

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Migraine pain is often preceded, accompanied and followed by dopaminergic symptoms (premonitory yawning and somnolence, accompanying nausea and vomiting, postdromal somnolence, euphoria and polyuria). After reviewing evidence from pharmacological, biochemical, genetic and animal experimental studies on the relationship between dopamine and migraine, and matching these data with patients' clinical features, we postulate that migraine attacks could be characterized by an ictal dopamine release in a subject with dopamine receptor hypersensitivity due to a chronic dopaminergic deficit synergistic to serotoninergic impairment. Our review suggests that when the attack begins, a low dopamine plasma concentration stimulates hypersensitive central presynaptic dopamine receptors thus causing prodromal symptoms such as yawning and somnolence. Increasing dopamine levels, though still insufficient to stop trigeminovascular activation, stimulate postsynaptic dopamine receptors thus inducing nausea, vomiting and hypotension. Finally, dopamine levels slowly return to baseline, giving rise to somnolence and fatigue, but, in some cases, continue to rise triggering postdromal symptoms such as euphoria and polyuria.

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Increased Dopamine Is Associated With the cGMP and Homocysteine Pathway in Female Migraineurs

Abstract: We show here that female migraineurs exhibit increased dopamine levels in the headache free period which are associated with a higher risk for migraine.

Cited by 7 publications

References 46 publications

Serum Homocysteine, Pyridoxine, Folate, and Vitamin B12 Levels in Migraine: Systematic Review and Meta‐Analysis

Serum Homocysteine, Pyridoxine, Folate, and Vitamin B12 Levels in Migraine: Systematic Review and Meta‐Analysis

A meta-analysis of biomarkers related to oxidative stress and nitric oxide pathway in migraine

Dopaminergic symptoms in migraine

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