Increased density of μ-opioid receptors in the postmortem brain of suicide victims

Gabilondo, Ane M.; Meana, J. Javier; Garcı́a-Sevilla, Jesús A.

doi:10.1016/0006-8993(95)00333-l

Cited by 123 publications

(89 citation statements)

References 34 publications

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“…However, clinical and biochemical evidence of alterations of the m-opioid receptor in suicide also exists. In line with the present results, it was previously shown that the density of m-opioid receptor sites is augmented in the post-mortem brain of depressed suicides (Gross-Isseroff et al, 1990;Gabilondo et al, 1995). Moreover, treatments with antidepressant drugs induce decreases in the receptor (and associated neuropeptide) levels (Hamon et al, 1987).…”

Section: Altered Expression Of L-opioid Receptors In the Brains Of Susupporting

confidence: 92%

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Increased mRNA Expression of α2A-Adrenoceptors, Serotonin Receptors and μ-Opioid Receptors in the Brains of Suicide Victims

Escribá

Ozaita

Garcı́a-Sevilla

2004

Neuropsychopharmacol

121

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The development of new therapies for the treatment of psychiatric disorders requires an in-depth knowledge of the molecular bases underlying these pathologies, which remain largely unknown. Alterations in adrenoceptors, serotonin receptors, and other G proteincoupled receptors (GPCRs) have been associated with suicide and depression. However, to date, there is little information about mRNA expression of the GPCRs in the frontal cortex of suicide victims. Our goal was to study the expression in the brain of these receptors. For this purpose, we measured mRNA levels by RT-PCR. We found that the expressions of a 2A -adrenoceptors, 5-HT 1A , 5-HT 2A serotonin receptors, and m-opioid receptors were elevated in the post-mortem brains of these suicide victims with respect to matched controls. Moreover, in the case of a 2A -adrenoceptors (the only for which these data were available), a significant correlation was observed between the level of mRNA and protein quantified in the brain of the same subjects, indicating that protein synthesis of this receptor was not influenced by post-translational regulatory mechanisms. In addition, the degree of adrenoceptor and 5-HT receptor expressions appeared to be correlated in the brains of suicide victims and control subjects. Alterations in the expression of adrenoceptors, serotonin, and opioid receptors indicate that these signaling proteins might be related to the etiopathology of suicidal and depressive behaviors. Alternatively, such changes may represent adaptive mechanisms to compensate for other as yet unknown alterations. The results also suggest that these receptors could share common regulatory mechanisms.

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Section: Altered Expression Of L-opioid Receptors In the Brains Of Susupporting

confidence: 92%

“…Finally, m-opioid receptors have been implicated in the behavioral alterations associated with stress. Indeed, its mRNA expression is augmented in the brain of rats submitted to stress (Yamamoto et al, 2003) and its protein levels were increased in the post-mortem brains of suicides (Gross-Isseroff et al, 1990;Gabilondo et al, 1995).…”

Section: Introductionmentioning

confidence: 99%

Increased mRNA Expression of α2A-Adrenoceptors, Serotonin Receptors and μ-Opioid Receptors in the Brains of Suicide Victims

Escribá

Ozaita

Garcı́a-Sevilla

2004

Neuropsychopharmacol

121

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“…However, significant human interindividual differences in the levels of expression of receptors are well documented in postmortem (Paronis and Holtzman 1992;Gabilondo et al 1995) and in vivo positron emission tomographic studies of receptor densities (Frost et al 1990). Heterozygous mice with half of wild-type receptor densities provide a potential model for the ways in which different levels of receptor expression could influence opiate drug responses in humans.…”

Section: Discussionmentioning

confidence: 99%

μ Opiate Receptor Gene Dose Effects on Different Morphine Actions Evidence for Differential in vivo μ Receptor Reserve

Sora¹,

Elmer

Funada

et al. 2001

Neuropsychopharmacology

133

118

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“…[59][60][61] The density of -opioid receptors has been reported to be elevated in young 62,63 but not in elderly 62 depressed suicide victims. The present study, comprising a distribution of subjects similar to the subgroup termed as old by Gross-Isseroff et al, 62 did not reveal differences in functional activity of -opioid receptors between suicide victims and controls.…”

Section: Molecular Psychiatrymentioning

confidence: 99%

Neurotransmitter receptor-mediated activation of G-proteins in brains of suicide victims with mood disorders: selective supersensitivity of α2A-adrenoceptors

et al. 2002

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Increased density of μ-opioid receptors in the postmortem brain of suicide victims

Cited by 123 publications

References 34 publications

Increased mRNA Expression of α2A-Adrenoceptors, Serotonin Receptors and μ-Opioid Receptors in the Brains of Suicide Victims

Increased mRNA Expression of α2A-Adrenoceptors, Serotonin Receptors and μ-Opioid Receptors in the Brains of Suicide Victims

μ Opiate Receptor Gene Dose Effects on Different Morphine Actions Evidence for Differential in vivo μ Receptor Reserve

Neurotransmitter receptor-mediated activation of G-proteins in brains of suicide victims with mood disorders: selective supersensitivity of α2A-adrenoceptors

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