Increased Density of Histiocytes in Uterine Leiomyomas

Adány, R; Fodor, F; Molnár, Péter; Ablin, R. J.; Muszbek, L.

doi:10.1097/00004347-199004000-00005

Cited by 15 publications

(4 citation statements)

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“…A significantly higher histiocytic count in leiomyomatous areas compared to adjacent normal myometrium was first observed by Adany et al . [ 5 ] Histiocytes were diffusely scattered throughout the leiomyomas while in the normal myometrium, they could be detected only in the connective tissue septa separating the bundles of smooth muscles. Histiocytes were assessed by immunoreactions for factor XIIIA, leading to speculation on its role in the pathogenesis of leiomyoma.…”

Section: Discussionmentioning

confidence: 99%

“…Histiocytes were assessed by immunoreactions for factor XIIIA, leading to speculation on its role in the pathogenesis of leiomyoma. [ 5 ]…”

Section: Discussionmentioning

confidence: 99%

“…[ 4 ] Moreover, Adany et al . [ 5 ] reported that histiocytic counts were significantly higher in leiomyomatous areas than in adjacent normal myometrium.…”

Section: Introductionmentioning

confidence: 99%

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Xanthogranulomatous Change in a Leiomyoma: First Report of an Extremely Rare Variant/Degenerative Change

Pujani

Singh

Chauhan

et al. 2023

Journal of Mid-Life Health

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Xanthogranulomatous inflammation, a specific form of chronic inflammation, is marked by parenchymal destruction, proliferative fibrosis, and infiltration of typical foamy histiocytes admixed with hemosiderin-laden macrophages and foreign-body giant cells. Myometrial xanthomatosis, a term designated for nodular or diffuse histiocytic hyperplasia of the myometrium, has been reported in association with pregnancy-related procedures. Moreover, a 2–3-fold increase in histiocytic counts has been observed in leiomyomatous areas than in adjacent normal myometrium. The first evidence of collections of lipid-laden macrophages was documented in the form of yellowish degeneration of uterine leiomyomas. We report a case of xanthogranulomatous change in a leiomyoma in a 47-year-old female who presented with abnormal uterine bleeding. To the best of our knowledge, this is the first report of xanthogranulomatous variant/degenerative change in a leiomyoma. This case highlights a new variant of leiomyoma which both gynecologists and pathologists should be aware of as it may pose a diagnostic challenge both clinically as well as pathologically.

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Section: Discussionmentioning

confidence: 99%

“…Histiocytes were assessed by immunoreactions for factor XIIIA, leading to speculation on its role in the pathogenesis of leiomyoma. [ 5 ]…”

Section: Discussionmentioning

confidence: 99%

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Xanthogranulomatous Change in a Leiomyoma: First Report of an Extremely Rare Variant/Degenerative Change

Pujani

Singh

Chauhan

et al. 2023

Journal of Mid-Life Health

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“…Benign uterine tumors (leiomyomas) are very common in the endometrial tissues of premenopausal women over the age of 40 and are strongly associated with chronic menorrhagia (Fraser, 1992). They are also associated with a significantly increased density of uterine macrophages (Adany et al, 1990), implying chronic inflammation and endometritis. Ewald's (1980) evolution-minded guidelines for the treatment of infectious diseases may be of use in deciding whether to mitigate heavy uterine bleeding.…”

Section: Clinical Data and Medical Implicationsmentioning

confidence: 99%

Menstruation as a Defense Against Pathogens Transported by Sperm

Profet

1993

The Quarterly Review of Biology

106

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Sperm are vectors of disease. During mammalian insemination bacteria from the male and female genitalia regularly cling to sperm tails and are transported to the uterus. I propose that menstruation functions to protect the uterus and oviducts from colonization by pathogens. Menstrual blood exerts mechanical pressure on uterine tissue, forcing it to shed, and delivers large numbers of immune cells throughout the uterine cavity, directly combating pathogens. The mechanisms of menstruation show evidence of adaptive design. Spiral arteries that open to the lining of the uterus trigger menstruation by abruptly constricting, which deprives the local tissue of blood, and then abruptly dilating, which causes blood to force loose the necrotic tissue. Menstrual blood flows easily, unlike blood at most wound sites, because it lacks the normal level of clotting factors. Overt (externally visible) or covert (not externally visible) menstruation has been documented in many species of primate, including Old World monkeys and apes, New World monkeys, and prosimians, as well as in various species of bat and insectivore. The antipathogen hypothesis predicts that: (1) menstruation (overt or covert) is either universal or nearly so among mammalian species; (2) if the latter, then the existence of menstruation among species varies inversely with the probability of becoming pregnant per estrous cycle (menstruation would be especially adaptive in species with significantly less than 100% probability of becoming pregnant per estrous cycle); (3) among menstruating species, the average degree of menstrual bleeding for a given species is a function of the factors affecting menstruation's costs and benefits--in particular, the degree of bleeding is positively correlated with the average body size and sexually transmitted pathogen load of that species (profuse bleeding would be especially adaptive in large-bodied species with either promiscuous breeding systems or continuous sexual receptivity); and (4) other forms of normal uterine bleeding--proestrous, periovulatory, implantation, and postpartum--also have an antipathogen function. The hypothesis presented in this article has implications for the diagnosis, treatment and prevention of uterine infection and, therefore, for the prevention of pathogen-induced infertility. The uterus appears to be designed to increase its bleeding if it detects infection: Human uteri that become infected (or otherwise inflamed) bleed more profusely, bleed on more days per cycle, and often bleed intermittently throughout the cycle. Thus artificially curtailing infection-induced uterine bleeding may be contraindicated.

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