Increased Densities of Langerhans Cells in the Epidermis of Skin Tumors

Yamaji, Kazuhiko; Matsui, M; Saida, Toshiaki

doi:10.1111/j.1346-8138.1987.tb02989.x

Cited by 16 publications

(5 citation statements)

References 24 publications

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“…Yamaji revealed an increased number of LCs overlying SCC using anti-CD1a and anti-S100 antibodies. However, no similar increase was registered in BCC [38]. For the authors, the degree of LCs increase paralleled the severity of inflammation and inflammatory infiltrates were observed around the tumour nests.…”

Section: Bcc and Sccmentioning

confidence: 82%

“…Smolle et al investigated the intraepithelial density of LCs in skin cancers and detected a significant depletion of LCs in both SCC and BCC, however, with their significantly higher density in SCC [37]. As a matter of fact, one has to note that in comparison with the other articles investigating both types of tumours, the higher density of LCs in SCC was found in three of them: in the aforementioned study by Smolle et al, in the study by Yamaji et al, and in the study by Chen et al; however, in the last one, the difference between tumour types was very subtle [37][38][39]. Another goal of the study by Chen et al was to find a correlation between the LCs density and degree of epithelial differentiation.…”

Section: Bcc and Sccmentioning

confidence: 86%

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Density of Langerhans Cells in Nonmelanoma Skin Cancers: A Systematic Review

Pogorzelska-Dyrbuś¹,

Szepietowski

2020

Mediators of Inflammation

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Langerhans cells (LCs) are bone marrow-derived dendritic cells (DCs) that represent 2-3% of the entire cell population of the human skin, known to have an ability to present antigens to T lymphocytes. Moreover, there is evidence that LCs are probably capable of inducing the local cytotoxic type T-cell-mediated response against the tumour-associated antigens. In the past two decades, a dramatic increase has been noted in the incidence of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The purpose of this study was to critically assess the results of available studies quantitatively assessing the LCs in nonmelanoma skin cancers and try to establish a conclusion of its possible impact on their future treatment. The PubMed, EMBASE, and the Web of Science databases were searched, which returned 948 citations. After a thorough analysis of full article texts, 30 studies have been chosen, including 11 of the BCC, 12 of the SCC specimens, and 7 analysing both tumour types. There was an overall trend towards slightly higher numbers of LCs in BCC than in SCC; however, these tendencies were discrepant between the studies. We presume that such differences could be caused by various staining techniques with a broad spectrum of specificity, including anti-S100, anti-CD1a, and ATPase activity staining used for LCs identification. We hypothesise that as there is a high inconsistency between the results of the studies, as far as the densities of LCs observed in the specimens are concerned, it seems that the mechanism of the influence of LCs on the antitumoural immune response is complicated. Finally, as at present, there is a paucity of available risk scores for the recurrence or progression of BCC or SCC, the creation of classification stratifying that risk including the density of LCs could bring additional information both for the physician and the patient.

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Section: Bcc and Sccmentioning

confidence: 82%

Section: Bcc and Sccmentioning

confidence: 86%

Density of Langerhans Cells in Nonmelanoma Skin Cancers: A Systematic Review

Pogorzelska-Dyrbuś¹,

Szepietowski

2020

Mediators of Inflammation

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“…LC have been observed in many benign and malignant tumors. 16–20 . Furthermore, alteration in density, distribution and morphology of LC have been reported with tumor progression 19–23 .…”

Section: Introductionmentioning

confidence: 99%

Langerhans cells and melanocytes share similar morphologic features under in vivo reflectance confocal microscopy: A?challenge for melanoma diagnosis

Hashemi

Pulitzer

Scope

et al. 2012

Journal of the American Academy of Dermatology

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Background Intraepidermal Langerhans cells (ILC) are difficult to differentiate from melanocytes under reflectance confocal microscopy (RCM) and their presence may simulate pagetoid spread of melanocytes on RCM images. Objective To correlate bright round and dendritic cells in a pagetoid pattern identified on RCM with findings of conventional histopathology and immunohistochemistry for lesions that were falsely diagnosed as melanoma by RCM. Methods This retrospective study included histopathologically proven nevi, imaged by RCM, which displayed bright cells in a pagetoid pattern (BCPP) under RCM, resulting in the incorrect RCM diagnosis of melanoma. Morphological comparisons were histopathologically proven melanomas displaying BCPP on RCM and biopsy-proven nevi without such cells on RCM. Results We identified 24 nevi that were falsely diagnosed as melanoma by RCM due to the presence of BCPP. These pagetoid cells on RCM corresponded on histopathology to ILC with a high density in 23 of the 24 nevi (95%) and to melanocytes in 7 of the 24 nevi (29%). Among 6 melanomas displaying BCPP on RCM, ILC with high density were observed histopathologically in 5 of the 6 cases (83%) and pagetoid melanocytes were seen in all 6 cases (100%). Limitations The results cannot be generalized to clinically banal-appearing nevi. Conclusions Although the finding of BCPP is a useful RCM feature for the diagnosis of melanoma it does not always imply the presence of pagetoid melanocytes but may at times, represent ILC.

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“…LC have been observed in many benign and malignant tumors. [16][17][18][19][20] . Furthermore, alteration in density, distribution and morphology of LC have been reported with tumor progression [19][20][21][22][23] .…”

Section: Introductionmentioning

confidence: 99%

Langerhans cells and melanocytes share similar morphologic features under in vivo reflectance confocal microscopy: A challenge for melanoma diagnosis

2011

Journal of the American Academy of Dermatology

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Background: Dermatology visits for the prevention and treatment of aging skin are increasing as patients live longer. The clinical sequelae of photodamage, including wrinkling, pigmentary changes, roughness, laxity, and telangiectasia, can all result in the appearance of aged skin. Antioxidant complex treatment has been formulated with ingredients known to improve the appearance of fine lines, wrinkles, and skin barrier function. Objective: To assess the efficacy and tolerability of antioxidant complex treatment in fine lines, wrinkles, and signs of photodamage. Methods: Thirty-four female subjects (Fitzpatrick classification I-IV) completed a 12week controlled clinical usage study. Antioxidant complex treatment was applied to the face, neck, and d ecolletage each morning. Efficacy was assessed using visual grading of facial and periocular skin, cutometry, and digital photography. Clinical evaluations and subject self-assessments were conducted at baseline and weeks 4, 8, and 12 using 10-point scales and skin condition assessment. Cutaneous tolerability was evaluated clinically and subjectively using a 4-point scale.Results: Significant improvements in all parameters and skin condition were seen as early as week 4 (P # .05). There was an 18% improvement in overall appearance by week 12 (P # .05) compared to baseline. Mean scores for fine lines and coarse winkles improved by 27% and 15% respectively (both P # .05 vs baseline). Significant improvements were also seen in uneven pigmentation, firmness/elasticity, toned/resiliency, skin radiance, tone, and tactile roughness/smoothness (10%, 11%, 18%, 21%, 16%, and 47%, respectively; all P # .05 vs baseline). By week 12, subjects reported a 43% improvement in overall facial skin appearance and 24% reduction in mean scores for facial lines and wrinkles (both P # .05 vs baseline). Improvements were also reported in overall skin tone, firmness, dryness, appearance of pores, appearance of brown spots/facial discoloration, skin radiance, and texture (37%, 35%, 35%, 28%, 24%, 39%, and 38%, respectively; all P # .05 vs baseline). There was a 71% reduction in erythema and 94% reduction in skin dryness by week 12 (both P # .05 vs baseline).Conclusion: Antioxidant complex treatment is effective and well-tolerated when treating photodamage and improves the appearance of fine lines and wrinkles.

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Increased Densities of Langerhans Cells in the Epidermis of Skin Tumors

Cited by 16 publications

References 24 publications

Density of Langerhans Cells in Nonmelanoma Skin Cancers: A Systematic Review

Density of Langerhans Cells in Nonmelanoma Skin Cancers: A Systematic Review

Langerhans cells and melanocytes share similar morphologic features under in vivo reflectance confocal microscopy: A?challenge for melanoma diagnosis

Langerhans cells and melanocytes share similar morphologic features under in vivo reflectance confocal microscopy: A challenge for melanoma diagnosis

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