Increased Delivery of Doxorubicin Into Tumor Cells Using Extracellularly Activated TAT Functionalized Liposomes: &lt;I&gt;In&lt;/I&gt; &lt;I&gt; Vitro&lt;/I&gt; and &lt;I&gt;In&lt;/I&gt; &lt;I&gt;Vivo&lt;/I&gt; Study

Yuan, Wenjie; Kuai, Rui; Ran, Rui; Fu, Lin; Yang, Yuting; Yao, Qin; Liu, Yayuan; Tang, Jie; Fu, Han; Zhang, Qianyu; Yuan, Mingqing; Zhang, Zhirong; Gao, Fabao; He, Qin

doi:10.1166/jbn.2014.1837

Cited by 15 publications

(9 citation statements)

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“…dilution or degradation, suggesting drug carrier systems for the transport of drugs and other bioactive capsules to disease affected organs. [36][37][38] We have developed a novel FR-targeted liposomes by incorporating a bifunctional SP-DS3 peptide consisting of the neck domain of surfactant proteins, which serves both as a linker and an anchor of the FA to the liposomal membrane. This delivery system proved to be more efficient than classic systems where the FA is linked to liposomes by PEG.…”

Section: Discussionmentioning

confidence: 99%

Enhancing Methotrexate Tolerance with Folate Tagged Liposomes in Arthritic Mice

Nogueira¹,

Lager²,

Roux³

et al. 2015

j biomed nanotechnol

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Methotrexate is the first line of treatment of rheumatoid arthritis. Since many patients become unresponsive to methotrexate treatment, only very expensive biological therapies are effective and increased methotrexate tolerance strategies need to be identified. Here we propose the encapsulation of methotrexate in a new liposomal formulation using a hydrophobic fragment of surfactant protein conjugated to a linker and folate to enhance their tolerance and efficacy. In this study we aim to evaluate the efficiency of this system to treat rheumatoid arthritis, by targeting folate receptor β present at the surface of activated macrophages, key effector cells in this pathology. The specificity of our liposomal formulation to target folate receptor β was investigated both in vitro as in vivo using a mouse model of arthritis (collagen-induced arthritis in DBA/1J mice strain). In both systems, the liposomal constructs were shown to be highly specific and efficient in targeting folate receptor β. These liposomal formulations also significantly increase the clinical benefit of the encapsulated methotrexate in vivo in arthritic mice, together with reduced expression of CD39 and CD73 ectonucleotidases by joint-infiltrating macrophages. Thus, our formulation might be a promising cost effective way to treat rheumatoid arthritis and delay or reduce methotrexate intolerance.

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Section: Discussionmentioning

confidence: 99%

Enhancing Methotrexate Tolerance with Folate Tagged Liposomes in Arthritic Mice

Nogueira¹,

Lager²,

Roux³

et al. 2015

j biomed nanotechnol

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“…TAT functionalized liposomes conjugated to DOX increased cancer cell apoptosis by 37.1%. PEG modified liposomes are activated extracellularly by cysteine to achieve higher in vivo tumor uptake [59]. Similarly, DOX conjugated dextran and phenylboronic acid cholesterol (chol-PBA) nanomicelles demonstrated significant lysosomal-acidity dependent nuclear uptake of DOX nanomicelles.…”

Section: Intracellular Targeted Drug Deliverymentioning

confidence: 99%

Novel delivery approaches for cancer therapeutics

Mitra

Agrahari

Mandal

et al. 2015

Journal of Controlled Release

130

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Currently, a majority of cancer treatment strategies are based on the removal of tumor mass mainly by surgery. Chemical and physical treatments such as chemo- and radiotherapies have also made a major contribution in inhibiting rapid growth of malignant cells. Furthermore, these approaches are often combined to enhance therapeutic indices. It is widely known that surgery, chemo- and radiotherapy also inhibit normal cells growth. In addition, these treatment modalities are associated with severe side effects and high toxicity which in turn lead to low quality of life. This review encompasses novel strategies for more effective chemotherapeutic delivery aiming to generate better prognosis. Currently, cancer treatment is a highly dynamic field and significant advances are being made in the development of novel cancer treatment strategies. In contrast to conventional cancer therapeutics, novel approaches such as ligand or receptor based targeting, triggered release, intracellular drug targeting, gene delivery, cancer stem cell therapy, magnetic drug targeting and ultrasound-mediated drug delivery, have added new modalities for cancer treatment. These approaches have led to selective detection of malignant cells leading to their eradication with minimal side effects. Lowering, multi-drug resistance and involving influx transportation in targeted drug delivery to cancer cells can also contribute significantly in the therapeutic interventions in cancer.

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“…Transactivator of transcription (TAT) peptide, a widely accepted cell-penetrating peptide that can penetrate across the cell membrane in less than 1 minute, has been successfully utilized to modify several polymers to enhance their cell-penetrating capability. 29,30 In the present study, lowmolecular-weight CS (LMWC) conjugated with TAT peptide was used for noncovalent functionalization of multiwalled CNTs (MWCNTs), aiming at providing a more efficient drug delivery vehicle for cancer therapy. The TAT-CS-conjugated MWCNTs (MWCNTs-TC) were further investigated for their water solubility, cytotoxicity, cell-penetrating capability, and in vivo accumulation in the target tumor tissues.…”

Section: Dong Et Almentioning

confidence: 99%

Transactivator of transcription (TAT) peptide–chitosan functionalized multiwalled carbon nanotubes as a potential drug delivery vehicle for cancer therapy

Dong¹,

Liu²,

Zhu³

et al. 2015

IJN

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Carbon nanotube (CNT)-based drug delivery vehicles might find great potential in cancer therapy via the combination of chemotherapy with photothermal therapy due to the strong optical absorbance of CNTs in the near-infrared region. However, the application of CNTs in cancer therapy was considerably constrained by their lack of solubility in aqueous medium, as well as the cytotoxicity caused by their hydrophobic surface. Intracellular delivery efficiency is another factor determining the application potential of CNTs in cancer therapy. In the present study, low-molecular-weight chitosan conjugated with transactivator of transcription (TAT) peptide was used for noncovalent functionalization of multiwalled carbon nanotubes (MWCNTs), aiming at providing a more efficient drug delivery vehicle for cancer therapy. The TAT–chitosan-conjugated MWCNTs (MWCNTs-TC) were further investigated for their water solubility, cytotoxicity, cell-penetrating capability, and accumulation in tumor. It was found that MWCNTs-TC were essentially nontoxic with satisfying water solubility, and they were more efficient in terms of cancer-targeted intracellular transport both in vitro and in vivo as compared with chitosan-modified MWCNTs (MWCNTs-CS), suggesting the great application potential of MWCNTs-TC in cancer therapy.

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Increased Delivery of Doxorubicin Into Tumor Cells Using Extracellularly Activated TAT Functionalized Liposomes: <I>In</I> <I> Vitro</I> and <I>In</I> <I>Vivo</I> Study

Cited by 15 publications

References 0 publications

Enhancing Methotrexate Tolerance with Folate Tagged Liposomes in Arthritic Mice

Enhancing Methotrexate Tolerance with Folate Tagged Liposomes in Arthritic Mice

Novel delivery approaches for cancer therapeutics

Transactivator of transcription (TAT) peptide–chitosan functionalized multiwalled carbon nanotubes as a potential drug delivery vehicle for cancer therapy

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Increased Delivery of Doxorubicin Into Tumor Cells Using Extracellularly Activated TAT Functionalized Liposomes: <I>In</I> <I> Vitro</I> and <I>In</I> <I>Vivo</I> Study

Cited by 15 publications

References 0 publications

Enhancing Methotrexate Tolerance with Folate Tagged Liposomes in Arthritic Mice

Enhancing Methotrexate Tolerance with Folate Tagged Liposomes in Arthritic Mice

Novel delivery approaches for cancer therapeutics

Transactivator of transcription (TAT) peptide&ndash;chitosan functionalized multiwalled carbon nanotubes as a potential drug delivery vehicle for&nbsp;cancer therapy

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Transactivator of transcription (TAT) peptide–chitosan functionalized multiwalled carbon nanotubes as a potential drug delivery vehicle for cancer therapy