Increased default mode network connectivity and increased regional homogeneity in migraineurs without aura

Zhang, Jilei; Su, Jingjing; Wang, Mengxing; Zhao, Ying; Yao, Qian; Zhang, Qiting; Lu, Haifeng; Zhang, Hui; Wang, Shuo; Li, Gefei; Wu, Yi-Lan; Liu, Feng-Di; Shi, Yan-Hui; Li, Jianqi; Liu, Jian-Ren; Du, Xiaoxia

doi:10.1186/s10194-016-0692-z

Cited by 71 publications

(70 citation statements)

References 37 publications

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“…Frontal regions have previously been found to have abnormal structure, function, and functional connectivity in individuals with different headache types including migraine, cluster headache, and medication overuse headache [ 22 – 26 ]. The precuneus, a core region of the default mode network that is responsible for self-referential processing and interoception, participates in the determination of pain sensitivity and pain thresholds [ 27 – 30 ]. Prior studies have implicated the precuneus and the default mode network in headache disorders including migraine, medication overuse headache, and cluster headache [ 22 , 30 – 33 ].…”

Section: Discussionmentioning

confidence: 99%

Persistent post-traumatic headache vs. migraine: an MRI study demonstrating differences in brain structure

et al. 2017

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BackgroundThe majority of individuals with post-traumatic headache have symptoms that are indistinguishable from migraine. The overlap in symptoms amongst these individuals raises the question as to whether post-traumatic headache has a unique pathophysiology or if head trauma triggers migraine. The objective of this study was to compare brain structure in individuals with persistent post-traumatic headache (i.e. headache lasting at least 3 months following a traumatic brain injury) attributed to mild traumatic brain injury to that of individuals with migraine.MethodsTwenty-eight individuals with persistent post-traumatic headache attributed to mild traumatic brain injury and 28 individuals with migraine underwent brain magnetic resonance imaging on a 3 T scanner. Regional volumes, cortical thickness, surface area and curvature measurements were calculated from T1-weighted sequences and compared between subject groups using ANCOVA. MRI data from 28 healthy control subjects were used to interpret the differences in brain structure between migraine and persistent post-traumatic headache.ResultsDifferences in regional volumes, cortical thickness, surface area and brain curvature were identified when comparing the group of individuals with persistent post-traumatic headache to the group with migraine. Structure was different between groups for regions within the right lateral orbitofrontal lobe, left caudal middle frontal lobe, left superior frontal lobe, left precuneus and right supramarginal gyrus (p < .05). Considering these regions only, there were differences between individuals with persistent post-traumatic headache and healthy controls within the right lateral orbitofrontal lobe, right supramarginal gyrus, and left superior frontal lobe and no differences when comparing the migraine cohort to healthy controls.ConclusionsIn conclusion, persistent post-traumatic headache and migraine are associated with differences in brain structure, perhaps suggesting differences in their underlying pathophysiology. Additional studies are needed to further delineate similarities and differences in brain structure and function that are associated with post-traumatic headache and migraine and to determine their specificity for each of the headache types.

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Section: Discussionmentioning

confidence: 99%

Persistent post-traumatic headache vs. migraine: an MRI study demonstrating differences in brain structure

et al. 2017

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“…Disruption of intra-DMN connectivity was, however, found in migraine patients who were scanned between attacks (15)(16)(17)(18)(19)(20). Interictal spontaneous activity was significantly decreased in the major regions of the DMN (15-18), including the PCC, IPL and MPFC, and the latter activity was negatively correlated with the duration of the migraine disorder (16,17).…”

Section: Interregional Dmn Connectivitymentioning

confidence: 99%

“…As in certain chronic pain conditions (12)(13)(14), seedbased RS-fMRI studies in migraine between attacks have provided evidence of a disruption of the default mode network (DMN) (15)(16)(17)(18)(19)(20), a set of brain regions active at rest and involved in self-referential orientation and monitoring (21). Intriguingly, in chronic pain disorders, such as fibromyalgia and low-back pain, such studies have revealed a positive correlation between the intensity of pain and resting DMN connectivity with the insula (INS) (22,23) and this correlation persists with manoeuvre-induced exacerbation of pain in chronic low back pain patients (24).…”

Section: Introductionmentioning

confidence: 99%

Resting state connectivity between default mode network and insula encodes acute migraine headache

et al. 2017

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Background: Previous functional MRI studies have revealed that ongoing clinical pain in different chronic pain syndromes is directly correlated to the connectivity strength of the resting default mode network (DMN) with the insula. Here, we investigated seed-based resting state DMN-insula connectivity during acute migraine headaches. Methods: Thirteen migraine without aura patients (MI) underwent 3 T MRI scans during the initial six hours of a spontaneous migraine attack, and were compared to a group of 19 healthy volunteers (HV). We evaluated headache intensity with a visual analogue scale and collected seed-based MRI resting state data in the four core regions of the DMN: Medial prefrontal cortex (MPFC), posterior cingulate cortex (PCC), and left and right inferior parietal lobules (IPLs), as well as in bilateral insula. Results: Compared to HV, MI patients showed stronger functional connectivity between MPFC and PCC, and between MPFC and bilateral insula. During migraine attacks, the strength of MPFC-to-insula connectivity was negatively correlated with pain intensity. Conclusion: We show that greater subjective intensity of pain during a migraine attack is associated with proportionally weaker DMN-insula connectivity. This is at variance with other chronic extra-cephalic pain disorders where the opposite was found, and may thus be a hallmark of acute migraine head pain.

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“…There are extensive connections between the precuneus and the dorsal premotor area, the supplementary motor area and the anterior cingulate cortex 26 . Compared with controls, migraineurs without aura showed a significant decrease in functional resting-state connectivity between the left precuneus and the left inferior and superior occipital gyrus, bilateral middle occipital gyrus, bilateral cuneus, bilateral superior parietal lobules, bilateral somatosensory cortex, bilateral dorsolateral prefrontal cortices, right premotor cortex, pons, bilateral cerebellar posterior lobes, right paracentral lobule, right middle cingulate gyrus and bilateral supplementary motor areas 27 . All these brain regions are involved with pain processing 23 .…”

Section: Discussionmentioning

confidence: 86%

Migraine improvement correlates with posterior cingulate cortical thickness reduction

Amaral

Tukamoto

Kubo

et al. 2018

Arq. Neuro-Psiquiatr.

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Objective The main goal of this study was to correlate migraine improvement, after prophylactic therapy, with cortical thickness changes. Methods Cortical thickness maps were obtained with magnetic resonance imaging (MRI) from 19 patients with migraine before (first scan) and after (second scan) prophylactic treatment, and these were compared with controls using the FreeSurfer MRI tool. Cortical changes were correlated with the headache index (HI). Results Anincrease incortical thickness was found in the right cuneus and precuneus, somatosensory and superior parietal cortices in both patient scans, compared with the controls. No changes were observed in the left hemisphere. Following correction for multiple comparisons, no areas changed from the first to the second scan. Regression analysis showed a significant negative correlation between the HI improvement and cortical thickness changes in the left posterior cingulate, a region involved with nociception and, possibly, the development of chronic pain. Conclusion There were changes in cortical thickness in patients with migraine relative to controls in areas involved with vision and pain processing. Left posterior cingulate cortical changes correlated with headache frequency and intensity.

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Increased default mode network connectivity and increased regional homogeneity in migraineurs without aura

Cited by 71 publications

References 37 publications

Persistent post-traumatic headache vs. migraine: an MRI study demonstrating differences in brain structure

Persistent post-traumatic headache vs. migraine: an MRI study demonstrating differences in brain structure

Resting state connectivity between default mode network and insula encodes acute migraine headache

Migraine improvement correlates with posterior cingulate cortical thickness reduction

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