Increased de novo lipogenesis in liver contributes to the augmented fat deposition in dexamethasone exposed broiler chickens (Gallus gallus domesticus)

Cai, Yuanli; Song, Zhigang; Zhang, Xinghao; Wang, Xiaojuan; Jiao, Hongchao; Lin, Hai

doi:10.1016/j.cbpc.2009.04.005

Cited by 58 publications

(58 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our previous studies of broiler chickens, GCs in concert with the high circulating concentration of insulin stimulated de novo hepatic lipogenesis, which in turn augmented blood lipid fl ux and peripheral fat deposition ( 12,13 ). In the present study, the circulating insulin level was signifi cantly increased in CORT-treated hens.…”

Section: Gcs Decrease Yolk Precursor Secretion By Suppressing Apoliposupporting

confidence: 58%

“…In our previous work on immature chickens, GCs stimulated energy intake ( 11 ) and enhanced hepatic lipogenesis and fat deposition in adipose tissues, indicating the redistribution of energy stores in CORT-challenged chickens (12)(13)(14). GCs trigger physiological and behavioral adjustments that shift energy investment away from reproduction and toward survival ( 15 ).…”

Section: Methodsmentioning

confidence: 95%

See 1 more Smart Citation

Corticosterone regulation of ovarian follicular development is dependent on the energy status of laying hens

Wang¹,

Li²,

Song³

et al. 2013

Journal of Lipid Research

Self Cite

View full text Add to dashboard Cite

This article is available online at http://www.jlr.org secretion of gonadotropin-releasing hormone (GnRH) from the hypothalamus stimulates the release of the pituitary gonadotropins, luteinizing hormone (LH), and folliclestimulating hormone (FSH), which in turn activate gonadal development and release of sex steroids, including estradiol (E2) and testosterone. Stress is a common problem disrupting breeding in either wild birds or domestic chickens ( 1 ). Glucocorticoids (GC), as the fi nal effectors of the hypothalamic-pituitary-adrenal axis, participate in the control of whole body homeostasis and the arousal of stress responses. GCs transmit information about environmental conditions to the HPG axis, which ultimately infl uences the timing of breeding.Female kittiwakes with low baseline LH levels and elevated levels of baseline corticosterone (CORT), the main form of GCs in avians, were more likely to skip breeding ( 2 ). An experimental reduction of CORT release during the prelaying period was associated with an advancement of egg laying in female kittiwakes ( 3 ). In domestic chickens, an acute infusion of CORT resulted in a pause in laying and a severely reduced ovarian weight ( 4 ). Chronic and repeated exposure to CORT during the rearing phrase suppressed reproductive performance, resulting in a delay of fi rst egg laid and a reduction of egg production ( 5 ).In avians, the development of ovarian follicles is accompanied by the deposition of a large amount of yolk. During a laying cycle, follicular development is matched with a supply of yolk precursors. Triacylglycerols (TG), the main

show abstract

Section: Gcs Decrease Yolk Precursor Secretion By Suppressing Apoliposupporting

confidence: 58%

Section: Methodsmentioning

confidence: 95%

Corticosterone regulation of ovarian follicular development is dependent on the energy status of laying hens

Wang¹,

Li²,

Song³

et al. 2013

Journal of Lipid Research

Self Cite

View full text Add to dashboard Cite

show abstract

“…Glucocorticoids regulate adipose differentiation, function, and distribution and in excess, promote hyperlipidemia [5]. Daily GC exposure has been shown to decrease body weight and feed intake in broiler chickens after 2 weeks, however, no significant long-term changes in ATGL expression were observed at the conclusion of the study [6]. It is the hypothesis of this study that injection of dexamethasone may acutely increase ATGL expression and increase plasma fatty acids in broiler chickens.…”

Section: Introductionmentioning

confidence: 79%

“…Glucocorticoids, primarily corticosterone in chickens, are the final effectors of the hypothalamic-pituitary-adrenal axis [6]. Synthesis of GC occurs in the adrenal cortex and has a wide array of metabolic effects to maintain homeostasis during times of stress [4], including the elevation of circulating free fatty acids and hepatic glucose [3,10].…”

Section: Discussionmentioning

confidence: 99%

Acute Up‐Regulation of Adipose Triglyceride Lipase and Release of Non‐Esterified Fatty Acids by Dexamethasone in Chicken Adipose Tissue

Serr

Suh

et al. 2011

Lipids

View full text Add to dashboard Cite

The mechanism of adipose tissue lipolysis has not been fully elucidated. Greater understanding of this process could allow for increased feed efficiency and reduced fat in poultry. Studies in avian species may provide important insight in developing therapies for human obesity, as lipolytic pathways are highly conserved. Adipose triglyceride lipase (ATGL) cleaves triacylglycols, releasing non-esterified fatty acids (NEFA) into the bloodstream. Glucocorticoids have been shown to elevate circulating NEFA. To determine the regulation of ATGL and regulator proteins comparative gene identification-58 (CGI-58) and G(0)/G(1) switch gene 2 (G0S2) by glucocorticoid, 36 chickens received an injection of dexamethasone (4 mg/kg). Saline was administered to an additional 12 birds to determine any effect of stress during handling. Dexamethasone-injected birds were harvested at 0, 0.5, 1, 2, 4, and 6 h after treatment; saline-treated birds were collected at 4 and 6 h. Abdominal and subcutaneous adipose tissue and blood were collected. Gene and protein expression were analyzed via quantitative real-time PCR and western blot. Compared with the saline group, ATGL expression increased in birds injected with dexamethasone. When dexamethasone response was compared to the untreated group up to 6 h following injection, an increase in ATGL protein was observed as quickly as 0.5 h and increased further from 1 to 6 h. Plasma NEFA and glucose increased gradually from 0 to 6 h, reaching statistical significance at 4 h. These data show that ATGL expression is stimulated by glucocorticoid in a time-dependent manner.

show abstract

“…In a previous study, chickens treated with DEX for both short and long periods all showed elevated circulating corticosterone, indicating a stress response [31][32][33][34]. Oxidative stress is a major pathological mechanism involved in the maladaptation to chronic stress [35].…”

Section: Dex Induced Oxidative Damage In Plasmamentioning

confidence: 90%

A high-caloric diet rich in soy oil alleviates oxidative damage of skeletal muscles induced by dexamethasone in chickens

et al. 2017

Self Cite

View full text Add to dashboard Cite

A high-caloric diet rich in soy oil alleviates oxidative damage of skeletal muscles induced by dexamethasone in chickens, Redox Report, 23:1, 68-82, DOI: 10.1080/13510002.2017 Objective: Glucocorticoids (GCs) can induce oxidative damage in skeletal muscles. The purpose of this study was to demonstrate a high caloric (HC) diet rich in soy oil would change the oxidative stress induced by a GC. Methods: The effect of dexamethasone (DEX) and HC diet on oxidative stress in plasma, skeletal muscles (M. pectoralis major, PM; M. biceps femoris, BF), and mitochondria were determined. The biomarkers of oxidative damage and antioxidative enzyme activity were determined. The fatty acid profile of muscles and the activities of complex I and II in mitochondria were measured. Results:The results showed that DEX increased the concentrations of oxidative damage markers in plasma, muscles, and mitochondria. The activity of complex I was significantly suppressed by DEX. DEX-chickens had higher proportions of polyunsaturated fatty acids and lower proportions of monounsaturated fatty acids in the PM. A HC diet decreased the levels of oxidative damage biomarkers in plasma, muscles, and mitochondria. The interaction between DEX and diet suppressed the activities of complex I and II in HC-chickens. Discussion: Oxidative damage in skeletal muscles and mitochondria was the result of GC-induced suppression of the activity of mitochondrial complex I. A HC diet improved the antioxidative capacity and reduced the oxidative damage induced by the GC.

show abstract

Increased de novo lipogenesis in liver contributes to the augmented fat deposition in dexamethasone exposed broiler chickens (Gallus gallus domesticus)

Cited by 58 publications

References 43 publications

Corticosterone regulation of ovarian follicular development is dependent on the energy status of laying hens

Corticosterone regulation of ovarian follicular development is dependent on the energy status of laying hens

Acute Up‐Regulation of Adipose Triglyceride Lipase and Release of Non‐Esterified Fatty Acids by Dexamethasone in Chicken Adipose Tissue

A high-caloric diet rich in soy oil alleviates oxidative damage of skeletal muscles induced by dexamethasone in chickens

Contact Info

Product

Resources

About