Increased Cytokine Secretion in Patients with Failed Implants Compared with Patients with Primary Implants

Waddell, Jennifer E; Pritzker, Kenneth P.H.; Boynton, Erin

doi:10.1097/01.blo.0000155079.29604.d4

Cited by 19 publications

(12 citation statements)

References 14 publications

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“…Although the precise mechanism remains unclear, wear debris-induced persistent inflammation, osteoclast formation, and osteoclastic bone resorption are important events in periprosthetic osteolysis [5,30]. The extent of osteolysis is dependent on particle composition, size, and amount, as well as duration of implantation.…”

Section: Discussionmentioning

confidence: 99%

Inhibitory effects of luteolin on titanium particle-induced osteolysis in a mouse model

et al. 2012

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Section: Discussionmentioning

confidence: 99%

Inhibitory effects of luteolin on titanium particle-induced osteolysis in a mouse model

et al. 2012

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“…5,6 Previous clinical studies have demonstrated elevated serum levels of proinflammatory cytokines in patients with active osteolysis after THA compared to healthy or osteoarthritis control subjects. 7,8 Peripheral blood mononuclear cells (PBMCs) taken from patients with active osteolysis show inducible cytokine responses in vitro that are greater than those from osteoarthritis subjects, 9 and the magnitude of these responses correlate with the severity of the associated clinical osteolytic lesion. 10 However, it remains unclear whether patients who are susceptible to osteolysis after THA have innately different cytokine responses to particulate debris versus patients after THA who do not demonstrate this susceptibility.…”

mentioning

confidence: 99%

Individual susceptibility to periprosthetic osteolysis is associated with altered patterns of innate immune gene expression in response to pro‐inflammatory stimuli

Gordon

Greenfield

Eastell

et al. 2010

Journal Orthopaedic Research

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Susceptibility to osteolysis after total hip arthroplasty (THA) varies between individuals. We examined whether patients susceptible to osteolysis (group I, n ¼ 34 subjects) after cemented Charnley THA have quantitatively different innate immune responses to pro-inflammatory stimuli versus patients without this susceptibility (group II, n ¼ 28 subjects) at a mean of 14 years after primary surgery. Extracted peripheral blood mononuclear cells were stimulated for 3 h using endotoxin (lipopolysaccharide-LPS, 100 ng/mL), endotoxinstripped titanium particles (Ti) or endotoxin-stripped particles with adherent LPS added-back (TI þ LPS). Subjects returned 1 week later and the experimental protocol was repeated. Assays for mRNA induction for interleukin (IL)-1a, IL-1b, IL-1Ra, IL-6, IL-10, IL-18, and tumor necrosis factor (TNF) were made using quantitative real-time PCR. Although baseline levels of mRNA expression were slightly lower in group I, inducibility of mRNA expression was markedly greater in group I versus group II for all cytokines in response to LPS or Ti þ LPS, and for IL-1a in response to Ti (P < 0.05). LPS or Ti þ LPS stimulation also resulted in an increase in the IL-1/IL-1Ra mRNA ratio in group I versus group II (P < 0.05). mRNA induction was highly reproducible between subject visits (r > 0.7, P < 0.001). Osteolysis-susceptible patients show repeatable, quantitatively different patterns of innate cytokine gene expression in response to pro-inflammatory stimuli versus THA patients who do not display this susceptibility. These innate immune differences may contribute to the variation in osteolysis-susceptibility observed clinically between individuals. ß

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“…Serum cytokines, such as serum IL-1 β or TNF- α , that have been suspected to be associated with development of osteolysis and loosening [35-38] had inconsistent associations with loosened prostheses [14, 15] and no association with osteolysis [7, 8]. We postulate that this may be due to lack of well-designed studies rather than lack of association.…”

Section: Discussionmentioning

confidence: 99%

Biomarkers in Arthroplasty: A Systematic Review

Mertens

Singh²

2011

TOORTHJ

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We performed a systematic review of all MEDLINE-published studies of biomarkers in arthroplasty. Thirty studies met the inclusion criteria; majority evaluated biomarkers for osteolysis, aseptic prosthetic loosening, and prosthetic infections. Four studies reported an elevated Cross-linked N-telopeptides of type I collagen (urine or serum) in patients with osteolysis or aseptic prosthetic loosening when compared to appropriate controls. Two or more studies each found elevated C-reactive protein, erythrocyte sedimentation rate, and interleukin-6 in patients with infected prosthetic joints compared to controls. Most other biomarkers were either examined by single studies or had inconsistent or insignificant associations with outcomes. We conclude that the majority of the biomarkers currently lack the evidence to be considered as biomarkers for arthroplasty outcomes. Further studies are needed.

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Increased Cytokine Secretion in Patients with Failed Implants Compared with Patients with Primary Implants

Cited by 19 publications

References 14 publications

Inhibitory effects of luteolin on titanium particle-induced osteolysis in a mouse model

Inhibitory effects of luteolin on titanium particle-induced osteolysis in a mouse model

Individual susceptibility to periprosthetic osteolysis is associated with altered patterns of innate immune gene expression in response to pro‐inflammatory stimuli

Biomarkers in Arthroplasty: A Systematic Review

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