Increased cystatin C concentration in urine of nephrotic children

Tkaczyk, Marcin; Nowicki, Michał; Lukamowicz, Jolanta

doi:10.1007/s00467-004-1566-1

Cited by 25 publications

(25 citation statements)

References 11 publications

(9 reference statements)

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“…In addition, the absence of circadian variation allows a measurement to be performed rapidly on a random sample (79). Raised urinary CysC concentrations are believed to indicate a tubular abnormality (77,(80)(81)(82).…”

Section: What Is the Renal Fate Of Cysc?mentioning

confidence: 99%

Cystatin C: current position and future prospects

Séronie-Vivien

Delanaye

Piéroni³

et al. 2008

Clinical Chemistry and Laboratory Medicine

163

145

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Cystatin C is a low-molecular-weight protein which has been proposed as a marker of renal function that could replace creatinine. Indeed, the concentration of cystatin C is mainly determined by glomerular filtration and is particularly of interest in clinical settings where the relationship between creatinine production and muscle mass impairs the clinical performance of creatinine. Since the last decade, numerous studies have evaluated its potential use in measuring renal function in various populations. More recently, other potential developments for its clinical use have emerged. This review summarises current knowledge about the physiology of cystatin C and about its use as a renal marker, either alone or in equations developed to estimate the glomerular filtration rate. This paper also reviews recent data about the other applications of cystatin C, particularly in cardiology, oncology and clinical pharmacology. Clin Chem Lab Med 2008;46:1664-86.

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Section: What Is the Renal Fate Of Cysc?mentioning

confidence: 99%

Cystatin C: current position and future prospects

Séronie-Vivien

Delanaye

Piéroni³

et al. 2008

Clinical Chemistry and Laboratory Medicine

163

145

View full text Add to dashboard Cite

show abstract

“…More recent studies have shown that factors other than renal function, such as C-reactive protein (CRP) and smoking status, may influence serum cystatin C concentrations, so that caution must be used when one is interpreting serum cystatin C levels as a measure of renal function [50]. The findings of cystatin C in the urine during glomerular and tubular injury also casts some doubt on the ability of serum cystatin C to accurately estimate GFR [51,52].…”

Section: Cystatin Cmentioning

confidence: 99%

“…where GFR (A)=Dose/[exp (A)/α], and C1=0.9908 and C2=−0.001218, as generated by Brochner-Mortensen in adults by comparing with plasma disappearance curves for 51 Cr-EDTA. Similar constants have been generated for children by Brochner-Mortensen [55], using comparable methodology (C1=1.01; C2=−0.0017), and recently by us in the CKiD pilot study [30] (C1=0.9950; C2=−0.001159).…”

Section: Single-injection Clearance Techniquesmentioning

confidence: 99%

“…Failure to accurately measure GFR may reflect the fact that the 99m Tc can dissociate from the DTPA during the study, and there can be variations in protein binding depending on the ligand attached to DTPA [59]. Some preparations with 99m Tc-DTPA gave results comparable to those with 51 Cr-EDTA, while others underestimated GFR by 7-22% [59]. Thus, the accuracy of 99m…”

Section: Single-injection Clearance Techniquesmentioning

confidence: 99%

“…Ethylene diamine tetra-acetic acid (EDTA) is another glomerular marker, with a molecular mass of 292 Da, and is used as a chelate of 51 Cr, primarily in Europe. Its plasma clearance exceeds its urinary clearance by~6 ml/min, particularly in patients with reduced renal function [58].…”

Section: Single-injection Clearance Techniquesmentioning

confidence: 99%

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Glomerular filtration rate measurement and estimation in chronic kidney disease

2007

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Glomerular filtration rate (GFR) assesses kidney function. GFR is measured by renal clearance techniques; inulin clearance is the gold standard but is not easily measured. Thus, other methods to determine GFR have been utilized. Endogenous creatinine clearance (CrCl) is the most widely used, but creatinine secretion falsely elevates GFR. Cimetidine inhibits creatinine secretion, such that CrCl equals GFR, provided there are no difficulties with bladder emptying. Estimation of GFR from serum creatinine (e.g. Schwartz formula) is useful clinically; however, such formulae have not been updated for enzymatic creatinine autoanalyzers. Cystatin C, a small protein, is produced at a relatively constant rate and is reabsorbed in the proximal tubule. Cystatin C may be more sensitive than creatinine in detecting a reduction in GFR, but further studies are needed to prove this. Single injection (plasma) clearance techniques are the most precise measures of GFR. Iohexol is an exogenous marker that is comparable to inulin and 51 Cr-EDTA and can be measured by high-performance liquid chromatography (HPLC). Our pilot and the Chronic Kidney Disease in Children (CKiD) North American studies show that iohexol can accurately measure GFR using a four-point plasma disappearance curve national studies show that iohexol can accurately measure GFR using a four-point plasma disappearance curve (10, 30, 120, and 300 min) or, in most cases, a two-point disappearance time (120 and 300 min).

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Biomarkers of Acute Kidney Injury

Dieterle¹,

Sistare²

2010

Biomarkers

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Increased cystatin C concentration in urine of nephrotic children

Cited by 25 publications

References 11 publications

Cystatin C: current position and future prospects

Cystatin C: current position and future prospects

Glomerular filtration rate measurement and estimation in chronic kidney disease

Biomarkers of Acute Kidney Injury

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