Increased Cortical Thickness in Alzheimer's Disease
Tony X. Phan,
Sheena Baratono,
William Drew
et al.
Abstract:ObjectivePatients with Alzheimer's disease (AD) have diffuse brain atrophy, but some regions, such as the anterior cingulate cortex (ACC), are spared and may even show increase in size compared to controls. The extent, clinical significance, and mechanisms associated with increased cortical thickness in AD remain unknown. Recent work suggested neural facilitation of regions anticorrelated to atrophied regions in frontotemporal dementia. Here, we aim to determine whether increased thickness occurs in sporadic A… Show more
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