Increased cortical surface area but not altered cortical thickness or gyrification in bipolar disorder following stabilisation from a first episode of mania

Rheenen, Tamsyn E Van; Cotton, Sue; Dandash, Orwa; Cooper, Rebecca; Ringin, Elysha; Daglas-Georgiou, Rothanthi; Allott, Kelly; Chye, Yann; Suo, Chao; Macneil, Craig A.; Hasty, Melissa K.; Hallam, K; McGorry, Patrick; Fornito, Alex; Yücel, Murat; Pantelis, Christos; Berk, Michael

doi:10.1016/j.pnpbp.2022.110687

Cited by 3 publications

(1 citation statement)

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“…Also, the children were ‘multi-dimensionally impaired’, i.e., they presented with a heterogenous clinical picture, comprising emotion dysregulation, attention deficit hyperactivity disorder, developmental disorders, and psychosis. Most recently, van Rheenen et al revealed that first episode of mania in adolescent and young adults (age 15–25) did not impact cortical thickness or gyrification but increased surface area was found in inferior and middle prefrontal and occipitoparietal cortices [ 93 ].…”

Section: Brain Changes Associated With Manic Episodesmentioning

confidence: 99%

Mania-related effects on structural brain changes in bipolar disorder – a narrative review of the evidence

et al. 2023

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Cross-sectional neuroimaging studies show that bipolar disorder is associated with structural brain abnormalities, predominantly observed in prefrontal and temporal cortex, cingulate gyrus, and subcortical regions. However, longitudinal studies are needed to elucidate whether these abnormalities presage disease onset or are consequences of disease processes, and to identify potential contributing factors. Here, we narratively review and summarize longitudinal structural magnetic resonance imaging studies that relate imaging outcomes to manic episodes. First, we conclude that longitudinal brain imaging studies suggest an association of bipolar disorder with aberrant brain changes, including both deviant decreases and increases in morphometric measures. Second, we conclude that manic episodes have been related to accelerated cortical volume and thickness decreases, with the most consistent findings occurring in prefrontal brain areas. Importantly, evidence also suggests that in contrast to healthy controls, who in general show age-related cortical decline, brain metrics remain stable or increase during euthymic periods in bipolar disorder patients, potentially reflecting structural recovering mechanisms. The findings stress the importance of preventing manic episodes. We further propose a model of prefrontal cortical trajectories in relation to the occurrence of manic episodes. Finally, we discuss potential mechanisms at play, remaining limitations, and future directions.

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Section: Brain Changes Associated With Manic Episodesmentioning

confidence: 99%

Mania-related effects on structural brain changes in bipolar disorder – a narrative review of the evidence

et al. 2023

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Geometric eigenmode brain fingerprinting and its longitudinal associations with adolescent mental health and wellbeing

Boyes,

Schwenn,

Shan

et al. 2024

Preprint

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Background‘Brain fingerprinting’ research posits that individual uniqueness can be identified by structural and functional features that may also be linked to mental health outcomes. Global structural features of the brain can be succinctly and directly captured from magnetic resonance imaging (MRI) via the eigenmodes of the cortical surface - known asgeometric eigenmodes. This research investigates how the uniqueness of geometric eigenmodes changes across adolescence and their longitudinal relation to mental health and wellbeing.MethodsThe current study utilised n=613 MRI, self-report and demographic datasets from N=116 community-recruited adolescents enrolled in the Longitudinal Adolescent Brain Study (LABS), between the ages of 12-17 years. MPRAGE scans at each participant’s visit were used to derive 225 left-hemisphere geometric eigenmodes. Eigenmodes were clustered into 14 eigengroups and developmental trajectories of their uniqueness and longitudinal associations with mental wellbeing and psychological distress were examined.ResultsAll eigengroups become significantly more unique longitudinally, and higher mode (shorter wavelength) eigengroups were more unique than lower mode groups in adolescence. Less uniqueness in ‘eigengroup 6’ was significantly associated with higher psychological distress and lower mental wellbeing at concurrent and future timepoints.ConclusionGeometric eigengroup brain fingerprinting offers a novel way to examine neurodevelopment. This study provides evidence that eigengroups have distinct trajectories from adolescence to adulthood, consistent with other imaging studies demonstrating increasing uniqueness in this period. Importantly, they are associated with mental health state and thus may represent neurobiological markers for mental illness onset, building on previous LABS research demonstrating that the functional uniqueness of the ‘cognitive control network’ predicts psychological distress four months later.

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The Impact of NAFLD-Related Indices on Brain Structure: Insights from Mendelian Randomization and Colocalization Analysis

Chen,

Fu,

et al. 2024

Preprint

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Increased cortical surface area but not altered cortical thickness or gyrification in bipolar disorder following stabilisation from a first episode of mania

Cited by 3 publications

References 93 publications

Mania-related effects on structural brain changes in bipolar disorder – a narrative review of the evidence

Mania-related effects on structural brain changes in bipolar disorder – a narrative review of the evidence

Geometric eigenmode brain fingerprinting and its longitudinal associations with adolescent mental health and wellbeing

The Impact of NAFLD-Related Indices on Brain Structure: Insights from Mendelian Randomization and Colocalization Analysis

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Increased cortical surface area but not altered cortical thickness or gyrification in bipolar disorder following stabilisation from a first episode of mania

Cited by 3 publications

References 93 publications

Mania-related effects on structural brain changes in bipolar disorder – a narrative review of the evidence

Mania-related effects on structural brain changes in bipolar disorder – a narrative review of the evidence

Geometric eigenmode brain fingerprinting and its longitudinal associations with adolescent mental health and wellbeing

The Impact of NAFLD-Related Indices on Brain Structure:&nbsp;Insights from Mendelian Randomization and Colocalization Analysis

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The Impact of NAFLD-Related Indices on Brain Structure: Insights from Mendelian Randomization and Colocalization Analysis