Increased Concentrations of Lactate Dehydrogenase in Pregnancy with Preeclampsia: A Predictor for the Birth of Small-for-Gestational-Age Infants

He, Songqing; Bremme, Katarina; Kallner, Anders; Blombäck, Margareta

doi:10.1159/000292417

Cited by 41 publications

(25 citation statements)

References 5 publications

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“…In the present study, 50% of babies had low birth weight with maternal serum LDH levels <600 IU/L where as 66 %of babies had low birth weight with maternal serum LDH levels > 600 IU/L. This indicates increase in preterm deliveries in patients with higher LDH levels .The association of low birth weight of infants with increase in serum LDH levels was suggested by He S [10] , et al in their study. This was in contrary to Qublan HS [8] , et al who did not find any significant association.…”

Section: Baby Weightsupporting

confidence: 64%

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Study of Relation of Lactate Dehydrogenase Levels with Severity of Preeclampsia and its foetal Outcome

2017

IJSR

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Background: Pre eclampsia is a multisystem disorder characterized by vascular endothelial dysfunction. Elevated levels of LDH indicates cellular damage and can be used as a biochemical marker to reflect complications and fetal outcome. Aim: To analyse the severity of preeclampsia and evaluate the outcome of baby by raised LDH levels. Material and methods: 100 patients with high blood pressure after 28 weeks of gestational age were included. The diagnosis of severe pre-eclampsia was made when a diastolic blood pressure was measured ≥110 mmHg on two or more occasions, or ≥120 mmHg on one or more occasions, in the context of significant proteinuria (≥300 mg/24 hours, or persistent ≥1+ on dipstick). Serum LDH level was done twice weekly .A baseline ultrasound was performed. Reversed end-diastolic flow was an indication for delivery. Observation and results: In severe preeclampsia group 40% patients had LDH levels >800 IU/L 50% of babies had low birth weight with maternal serum LDH levels <600 IU/L.66 %of babies had low birth weight with maternal serum LDH levels > 600 IU/L. Conclusion : Raised LDH levels can predict the occurrence of maternal and neonatal complications.

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Section: Baby Weightsupporting

confidence: 64%

“…He S, Brennen K [10] et al reported that pre eclamptic women with small for gestational age infants had higher LDH concentrations than those in the appropriate for gestational age group.…”

Section: Baby Weightmentioning

confidence: 99%

Study of Relation of Lactate Dehydrogenase Levels with Severity of Preeclampsia and its foetal Outcome

2017

IJSR

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“…He et al, study also proved that serum LDH were significantly higher with babies born between the gestational period of 24-29 weeks versus 30-35 weeks versus 36-40 weeks. 13,16 It also proved that low birth weights were seen in patients with higher serum LDH. Qulban et al, on contrary did not show any significant association between the low birth weight of infant and raised serum LDH levels.…”

Section: Discussionmentioning

confidence: 92%

A correlation of lactate dehydrogenase enzyme levels in pregnancy induced hypertensive disorders with severity of disease, maternal and perinatal outcome

Bhave

Shah

2017

Int J Reprod Contracept Obstet Gynecol

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INTRODUCTIONPregnancy causes various cardiovascular and metabolic changes in the mother's body of which change in the blood pressure is considered one significant change. Ten million women develop preeclampsia each year around the world.1 Across the world, around 76,000 pregnant women die each year from preeclampsia and related hypertensive disorders. And the number of babies who die from these disorders is thought to be on the order of 500,000 per annum. 2Pregnancy induced hypertensive disorders, seen in approximately 10% of pregnancies, include gestational hypertension, preeclampsia and eclampsia. 3 In the developing world, severe forms of preeclampsia and eclampsia are more common, ranging from a low of 4% of all deliveries to as high as 18% in parts of Africa. 4 ABSTRACT Background: A spectrum of hypertensive disorders in pregnancy contribute to maternal and perinatal morbidity and mortality. For prediction and early diagnosis of preeclampsia various biochemical markers, vascular function test and renal markers have been developed. The objective of the study is to measure the lactate dehydrogenase enzyme (LDH) levels in pregnant women with pregnancy induced hypertensive disorders and correlate the levels with the severity of condition, maternal and the perinatal outcome. Methods: In this prospective observational study, a total of 150 pregnant women were studied. Out of these 150 women, 30 women had normal blood pressure, 30 women had gestational hypertension, 30 women had mild preeclampsia, 30 women had severe preeclampsia and 30 women had eclampsia. The serum LDH levels were measured in third trimester and patients followed up until early postpartum period and babies were followed up till early neonatal period to assess the maternal and neonatal outcomes. Results: Higher lactate dehydrogenase enzyme (LDH) levels were observed in pregnant women with severe form of hypertensive disorder and those who had a poor maternal and perinatal outcome. This is statistically significant (p<0.001). Conclusions: Lactate dehydrogenase enzyme (LDH) level is a useful biochemical marker to assess and predict the severity of disease, maternal and perinatal outcome as higher levels of the enzyme are associated with worsening severity of disease, a poor maternal and perinatal outcome.

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“…They concluded that serum LDH can be a useful marker for the prediction of adverse outcome of pregnancy in severe preeclampsia. Serum LDH has also found to be a useful predictor of birth of small for gestational age infants in preeclamptic pregnancy [15]. Previous studies demonstrated the importance of amniotic serum LDH level for the prediction of fetal growth restriction.…”

Section: Discussionmentioning

confidence: 99%

Comparative study of serum LDH and uric acid in hypertensive versus normotensive pregnant woman

Gandhi¹,

Chavda²,

Saini³

2015

Int Jour of Biomed Res

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Aims & Objectives: Our aim is to compare the serum levels of Lactate dehydrogenase (LDH) and Uric Acid in hypertensive versus normotensive pregnant woman and correlate their levels with the severity of the disease. Material & Methods: 25 antenatal patients having hypertension (Group A) & equal no. of normotensive patients (Group B) were chosen. Three readings of blood pressure were recorded after 5 minutes rest, the interval between the measurements and the average value was recorded. About 3 ml of blood was drawn under aseptic precautions from selected subjects in a plain vial for serum. Serum was separated by centrifugation and used for estimation of serum levels of LDH and UA. Observation & Results: Demographic parameters and baseline values were nonsignificant between two groups. We have observed significant difference in serum LDH and Uric acid in hypertensive group patients in comparison with normotensive patients. Conclusion: We conclude that serum LDH and Serum Uric acid are reliable and inexpensive markers to predict severity and outcome of hypertensive disorders of pregnancy

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Increased Concentrations of Lactate Dehydrogenase in Pregnancy with Preeclampsia: A Predictor for the Birth of Small-for-Gestational-Age Infants

Cited by 41 publications

References 5 publications

Study of Relation of Lactate Dehydrogenase Levels with Severity of Preeclampsia and its foetal Outcome

Study of Relation of Lactate Dehydrogenase Levels with Severity of Preeclampsia and its foetal Outcome

A correlation of lactate dehydrogenase enzyme levels in pregnancy induced hypertensive disorders with severity of disease, maternal and perinatal outcome

Comparative study of serum LDH and uric acid in hypertensive versus normotensive pregnant woman

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