Increased Concentration of C-Reactive Protein in Obese Patients with Type 2 Diabetes Is Associated with Obesity and Presence of Diabetes but Not with Macrovascular and Microvascular Complications or Glycemic Control

Fronczyk, Aneta; Molęda, Piotr; Safranow, Krzysztof; Piechota, Wiesław; Majkowska, Lilianna

doi:10.1007/s10753-013-9746-4

Cited by 24 publications

(16 citation statements)

References 38 publications

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“…We further found that in T2D patients, plasma fractalkine levels were associated with circulatory concentrations of CRP which is a signature clinical marker for systemic inflammation. These results are in agreement with other studies that also report the increased CRP levels in obese/T2D individuals [41, 42]. …”

Section: Discussionsupporting

confidence: 94%

Increased circulatory levels of fractalkine (CX3CL1) are associated with inflammatory chemokines and cytokines in individuals with type-2 diabetes

Sindhu

Akhter

Arefanian

et al. 2017

J Diabetes Metab Disord

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BackgroundFractalkine (CX3CL1) is involved in the development of numerous inflammatory conditions including metabolic diseases. However, changes in the circulatory fractalkine levels in type-2 diabetes (T2D) and their relationship with inflammatory chemokines/cytokines remain unclear. The aim of the study was to determine the T2D-associated modulations in plasma fractalkine levels and investigate their relationship with circulatory chemokines/cytokines.MethodsA total of 47 plasma samples were collected from 23 T2D and 24 non-diabetic individuals selected over a wide range of body mass index (BMI). Clinical metabolic parameters were determined using standard commercial kits. Fractalkine and chemokines/cytokines were measured using Luminex X-MAP® technology. C-reactive protein (CRP) was measured by ELISA. The data were compared using unpaired t-test and the dependence between two variables was assessed by Pearson’s correlation coefficient (r).ResultsPlasma fractalkine levels were significantly higher (P = 0.005) in T2D patients (166 ± 14.22 pg/ml) as compared with non-diabetics (118 ± 8.90 pg/ml). In T2D patients, plasma fractalkine levels correlated positively (P ≤ 0.05) with inflammatory chemokines/cytokines including CCL3 (r = 0.52), CCL4 (r = 0.85), CCL11 (r = 0.51), CXCL1 (r = 0.67), G-CSF (r = 0.91), IFN-α2 (r = 0.97), IL-17A (r = 0.79), IL-1β (r = 0.97), IL-12P70 (r = 0.90), TNF-α (r = 0.58), and IL-6 (r = 0.60). In non-diabetic individuals, fractalkine levels correlated (P ≤ 0.05) with those of CCL4 (r = 0.49), IL-1β (r = 0.73), IL-12P70 (r = 0.41), and TNF-α (r = 0.50). Notably, plasma fractalkine levels in T2D patients associated with systemic inflammation (CRP) (r = 0.65, P = 0.02).ConclusionsThe altered plasma fractalkine levels associate differentially with inflammatory chemokines/cytokines in T2D patients which may have implications for T2D immunopathogenesis.Electronic supplementary materialThe online version of this article (doi:10.1186/s40200-017-0297-3) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 94%

Increased circulatory levels of fractalkine (CX3CL1) are associated with inflammatory chemokines and cytokines in individuals with type-2 diabetes

Sindhu

Akhter

Arefanian

et al. 2017

J Diabetes Metab Disord

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“…A biomarker that may shed light on the level of chronic inflammation is expected to both improve our understanding of the factors contributing to the progression of complications in diabetes and offer a mode for assessing therapeutic efficacy and novel therapeutic targets. Commonly used biomarkers for inflammation, such as CRP, have shown a loose correlation to actual disease outcome and may not be sufficiently specific to the diabetic disease process (8). Moreover, CRP levels fluctuate in successive measurements and respond to both chronic and acute inflammatory process, impeding its validity as a biomarker for chronic processes (19).…”

Section: Discussionmentioning

confidence: 99%

“…However, neither of these parameters is indicative of chronic inflammation or the patients' immune functionality. For example, conflicting results exist as to the correlation between CRP and diabetes-related microand macrovascular complications and its usefulness as a biomarker of disease progression (8). Additionally, the lack of CRP specificity regarding its ability to distinguish between acute and chronic inflammation and susceptibility to the effects of certain anti-inflammatory medications such as statins and aspirin (4), frequently used in diabetic patients, may diminish its usefulness in clinical practice.…”

mentioning

confidence: 99%

CD247, a Novel T Cell–Derived Diagnostic and Prognostic Biomarker for Detecting Disease Progression and Severity in Patients With Type 2 Diabetes

et al. 2014

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OBJECTIVEWe have previously shown that chronic inflammation results in immunosuppression associated with CD247 downregulation in T lymphocytes. Type 2 diabetes mellitus (T2DM) is known to be associated with chronic inflammation. We therefore sought to examine CD247 expression levels in patients with T2DM and to assess whether it can serve as a diagnostic and prognostic biomarker for disease complications and outcomes. RESEARCH DESIGN AND METHODSPeripheral blood samples from 75 T2DM patients and 40 healthy control subjects were collected and analyzed for the expression level of CD247 in T lymphocytes. Subjects with T2DM underwent a medical interview with physical examination and were followed for an additional average of 19.2 6 0.9 months to determine the occurrence of major adverse disease end points. The relationship between the level of CD247 expression and disease status at the time of blood draw and the ability of the marker to identify future complications was evaluated. RESULTSWe observed a significant reduction in CD247 expression levels in T lymphocytes of T2DM patients when compared with healthy volunteers. CD247 downregulation was associated with disease severity, complications, and the occurrence of future cardiovascular events, suggesting its potential use not only as a diagnostic but also as a prognostic biomarker. CONCLUSIONSOur results suggest the use of CD247 as a biomarker in diabetic patients for evaluating the state of chronic inflammation that contributes to morbidity and mortality in this disease and for the prediction of future cardiovascular events.Type 2 diabetes mellitus (T2DM) is associated with low-grade chronic inflammation, which may contribute to the development of diabetes-related complications (1). Several nonspecific biomarkers of inflammation, such as hs-CRP, TNF-a, lipoprotein (a), and sICAM-1, have been implicated in disease progression and activity and found to be significantly elevated in diabetic patients with existing coronary artery

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“…Hepatic inflammation and oxidative stress, as a result of steatosis is a potential contributor to the low-grade inflammation associated with obesity-related metabolic syndrome [33]. On the other hand, high calcium diet non significantly reduced the serum CRP level, which may be associated with the systemic inflammation during obese condition [34]. On the other hand, high calcium diet prevents oxidative stress by restoring the antioxidant level within the hepatocytes and plasma.…”

Section: Das and Choudhurimentioning

confidence: 99%

Prolonged Exposure to Different Types of Energy Restricted Calcium Diet Modulates the Inflammatory and Oxidative Stress Response in Healthy Male Rats

Das

Choudhuri

2019

Asian J Pharm Clin Res

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Objective: Emerging evidence established the role of dietary calcium in the modulation of obesity. Obesity is known to induce inflammatory and oxidative stress in adipocytes resulting in several metabolic complications. In the present study, we evaluated the role of low and high calcium diet on systemic inflammatory response and oxidative stress markers in both plasma and hepatic tissues in male rats. Methods: A total of 30 male rats were divided into three groups and fed with control, low calcium (0.25%), and high calcium (1.0%) diet for 3 months. All the diets were isocaloric in nature. At the end of the treatment, all rats were sacrificed, followed by collection of blood and hepatic tissue for inflammatory, oxidative, antioxidant, and histological study. Results: Rats fed with a low calcium diet showed a significant increase in the body weight gain, liver mass, plasma inflammatory markers C-reactive protein, interleukin-6, and tumor necrosis factor-alpha. Low calcium diet significantly increased the lipid peroxidation and protein carbonylation and decreased the superoxide dismutase and glutathione peroxidase activities in both plasma and liver. High calcium diet, on the other hand, showed the reversed effect. Conclusion: Low calcium in the diet, along with obesity, increases the systemic inflammatory response, which in turn increases oxidative stress both in blood and hepatic tissues. This might be associated with obesity-induced hepatic disorder. High calcium in diet attenuates this effect.

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Increased Concentration of C-Reactive Protein in Obese Patients with Type 2 Diabetes Is Associated with Obesity and Presence of Diabetes but Not with Macrovascular and Microvascular Complications or Glycemic Control

Cited by 24 publications

References 38 publications

Increased circulatory levels of fractalkine (CX3CL1) are associated with inflammatory chemokines and cytokines in individuals with type-2 diabetes

Increased circulatory levels of fractalkine (CX3CL1) are associated with inflammatory chemokines and cytokines in individuals with type-2 diabetes

CD247, a Novel T Cell–Derived Diagnostic and Prognostic Biomarker for Detecting Disease Progression and Severity in Patients With Type 2 Diabetes

Prolonged Exposure to Different Types of Energy Restricted Calcium Diet Modulates the Inflammatory and Oxidative Stress Response in Healthy Male Rats

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