Increased compliance in diaphragm muscle of the cardiomyopathic Syrian hamster

Coirault, Catherine; Samuel, J. L.; Chemla, Denis; Pourny, J. C.; Marotte, F.; Lecarpentier, Yves

doi:10.1152/jappl.1998.85.5.1762

Cited by 28 publications

(19 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The current results are in line with a previous study that reported decreased stiffness of diaphragm bundles from cardiomyopathic hamsters [24]. However, that study was unable to indicate a specific cause for reduced stiffness, because passive tension development of muscle bundles depends on elasticity of both intracellular and extracellular components, e.g.…”

Section: Discussionsupporting

confidence: 90%

Heart failure decreases passive tension generation of rat diaphragm fibers

Hees

Ottenheijm

Granzier

et al. 2010

International Journal of Cardiology

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 90%

Heart failure decreases passive tension generation of rat diaphragm fibers

Hees

Ottenheijm

Granzier

et al. 2010

International Journal of Cardiology

View full text Add to dashboard Cite

“…The Young's modulus of the human heart ranges between 200 and 500 kPa in the contracted state (25)(26)(27). Moreover, the left ventricle (LV) has unique mechanical anisotropy, with a measured anisotropy ratio of 2.1, that is essential for proper function (7).…”

Section: Resultsmentioning

confidence: 99%

Modular assembly of thick multifunctional cardiac patches

Fleischer

Shapira

Feiner

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

132

110

View full text Add to dashboard Cite

In cardiac tissue engineering cells are seeded within porous biomaterial scaffolds to create functional cardiac patches. Here, we report on a bottom-up approach to assemble a modular tissue consisting of multiple layers with distinct structures and functions. Albumin electrospun fiber scaffolds were laser-patterned to create microgrooves for engineering aligned cardiac tissues exhibiting anisotropic electrical signal propagation. Microchannels were patterned within the scaffolds and seeded with endothelial cells to form closed lumens. Moreover, cage-like structures were patterned within the scaffolds and accommodated poly(lactic-co-glycolic acid) (PLGA) microparticulate systems that controlled the release of VEGF, which promotes vascularization, or dexamethasone, an anti-inflammatory agent. The structure, morphology, and function of each layer were characterized, and the tissue layers were grown separately in their optimal conditions. Before transplantation the tissue and microparticulate layers were integrated by an ECM-based biological glue to form thick 3D cardiac patches. Finally, the patches were transplanted in rats, and their vascularization was assessed. Because of the simple modularity of this approach, we believe that it could be used in the future to assemble other multicellular, thick, 3D, functional tissues.

show abstract

“…The terrestrial mammalian diaphragm is composed of muscle, a collagenous central tendon and an elastin-rich ligament (Griffiths et al, 1992), each with different mechanical properties. Diaphragm muscle moduli range from 0.2 to 0.8MPa (Coirault et al, 1998;Gates et al, 1980), and a value of 33MPa has been used to model the tendon (Behr et al, 2006). The central tendon may be reduced or absent in cetaceans (Dearolf, 2002), but diaphragm movement may be constrained by other structures, including surface tendons that may be comparable to the elastic ligament and dorsolateral connective tissue connections to the subdermal sheath (Dearolf, 2002).…”

Section: Diaphragm Deformationmentioning

confidence: 99%

Cardiovascular design in fin whales: high-stiffness arteries protect against adverse pressure gradients at depth

Lillie

Piscitelli

Vogl

et al. 2013

Journal of Experimental Biology

View full text Add to dashboard Cite

SUMMARYFin whales have an incompliant aorta, which, we hypothesize, represents an adaptation to large, depth-induced variations in arterial transmural pressures. We hypothesize these variations arise from a limited ability of tissues to respond to rapid changes in ambient ocean pressures during a dive. We tested this hypothesis by measuring arterial mechanics experimentally and modelling arterial transmural pressures mathematically. The mechanical properties of mammalian arteries reflect the physiological loads they experience, so we examined a wide range of fin whale arteries. All arteries had abundant adventitial collagen that was usually recruited at very low stretches and inflation pressures (2-3kPa), making arterial diameter largely independent of transmural pressure. Arteries withstood significant negative transmural pressures (−7 to −50kPa) before collapsing. Collapse was resisted by recruitment of adventitial collagen at very low stretches. These findings are compatible with the hypothesis of depth-induced variation of arterial transmural pressure. Because transmural pressures depend on thoracic pressures, we modelled the thorax of a diving fin whale to assess the likelihood of significant variation in transmural pressures. The model predicted that deformation of the thorax body wall and diaphragm could not always equalize thoracic and ambient pressures because of asymmetrical conditions on dive descent and ascent. Redistribution of blood could partially compensate for asymmetrical conditions, but inertial and viscoelastic lag necessarily limits tissue response rates. Without pressure equilibrium, particularly when ambient pressures change rapidly, internal pressure gradients will develop and expose arteries to transient pressure fluctuations, but with minimal hemodynamic consequence due to their low compliance.

show abstract

Increased compliance in diaphragm muscle of the cardiomyopathic Syrian hamster

Cited by 28 publications

References 35 publications

Heart failure decreases passive tension generation of rat diaphragm fibers

Heart failure decreases passive tension generation of rat diaphragm fibers

Modular assembly of thick multifunctional cardiac patches

Cardiovascular design in fin whales: high-stiffness arteries protect against adverse pressure gradients at depth

Contact Info

Product

Resources

About