Increased circulating pro-inflammatory cytokines and imbalanced regulatory T-cell cytokines production in chronic idiopathic urticaria

Santos, Juliana Cristina dos; Azor, Mayce Helena; Nojima, Viviane Yoshimi; Lourenço, Francinelson Duarte; Prearo, E.; Maruta, Celina Wakisaka; Rivitti, Evandro A.; Duarte, Alberto José da Silva; Sato, Maria Notomi

doi:10.1016/j.intimp.2008.05.016

Cited by 78 publications

(97 citation statements)

References 38 publications

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“…Inflammatory cytokines like IL-2, IL-17, IFN-γ, and TNF-α act as inflammatory mediators and appear to be involved in the pathogenesis of autoimmune diseases, implicated in the development, differentiation, and regulation of immune cells [27,28,29,30]. These cytokines can also further immune cell recruitment and macrophage activation, promoting cell-mediated immunity and playing an integral role in the coordination and persistence of chronic inflammation [27].…”

Section: Introductionmentioning

confidence: 99%

Different Frequencies of Tc17/Tc1 and Th17/Th1 Cells in Chronic Spontaneous Urticaria

Lopes

Machado

Pedreiro

et al. 2013

Int Arch Allergy Immunol

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Background: Chronic urticaria is associated with an immune dysregulation usually mediated by T lymphocytes. Recently, Th17 and Tc17 have been implicated in autoimmune diseases; however, their role in urticaria is not clear yet. Methods: For the study we recruited 20 patients [10 of them had autoreactive chronic spontaneous urticaria (positive autologous intradermal serum test response, ASST+), and the other 10 were nonautoreactive chronic spontaneous urticaria patients (ASST–)] and 17 healthy age- and gender-matched controls (HG). The frequency and functional activity of Th17/Tc17 and Th1/Tc1 cells were evaluated by flow cytometry and type 2 cytokine mRNA by real-time PCR. Results: Our results demonstrated a significant decrease in Th17 frequency in both chronic urticaria groups compared to HG; regarding the amount of IL-17, at the single cell level, it was reduced in ASST– compared to HG. Concerning the Th1 and Th17 cells producing IFN-γ, IL-2, and TNF-α, a lower frequency was noted in chronic urticaria patients compared to HG. In contrast, a significantly increased frequency of Tc1 cells producing these cytokines was noted in ASST+ compared to HG and ASST–. Also, the frequency of Tc17 cells producing TNF-α was increased in ASST+ compared to HG; however, with respect to the amount of TNF-α, at the single cell level, we found a decrease in ASST+ compared to HG. Regarding type 2 cytokine mRNA, a higher expression was verified in ASST+ compared to HG. Conclusion: Our data suggest a probable involvement of cytotoxic T cells, mainly the Tc1 and Tc17 subsets, in chronic urticaria, particularly in the ASST+ group.

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Section: Introductionmentioning

confidence: 99%

Different Frequencies of Tc17/Tc1 and Th17/Th1 Cells in Chronic Spontaneous Urticaria

Lopes

Machado

Pedreiro

et al. 2013

Int Arch Allergy Immunol

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“…Downregulation of high affinity IgE receptors (FceRI) on mast cells, as a consequence of circulating IgE Reports on cytokine serum levels in chronic spontaneous urticaria patients are not numerous in the literature. Most of the studies have emphasized the observation of elevated levels of proinflammatory cytokines and their relationship with disease severity (12)(13)(14). Conversely, scant evidence exists with regard to Th2-type cytokines (15).…”

Section: Discussionmentioning

confidence: 99%

“…Conversely, scant evidence exists with regard to Th2-type cytokines (15). In addition, only a few cytokines in a given patient population have been evaluated in the studies available in the literature (12)(13)(14)(15).…”

Section: Discussionmentioning

confidence: 99%

Effects of omalizumab treatment on serum cytokine concentrations of atopic patients with chronic spontaneous urticaria: a preliminary report

Sellitto¹,

Fanis

Balestrieri

et al. 2017

Eur Ann Allergy Clin Immunol

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“…Up to 30%-50% of patients with chronic urticaria have autoantibodies to the a-chain of the high affinity receptor for IgE (FceRIa); it is thought that these autoantibodies cross-link the IgE receptors, therefore activating the infiltrating basophils and skin mast cells, leading to histamine release [1,3,4] . In addition, other circulating mediators may play a role in activation and histamine release studies have shown increases in pro-inflammatory cytokines, such as IL-1b, IL-12p70, TNF-a, IL-6, IL-10 and IL-17, in chronic idiopathic urticaria [5,6] . Crohn's disease is also a disease with autoimmune involvement, and there is evidence for an altered cytokine milieu leading to mucosal inflammation.…”

Section: Discussionmentioning

confidence: 99%

Angioedema associated with Crohnʼs disease: Response to biologics

Habal

Huang

2011

Inflammatory Bowel Diseases

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A 46-year-old female patient with terminal ileum Crohn's disease and ankylosing spondylitis presented with recurrent angioedema and urticaria. Investigations ruled out hereditary angioedema, and environmental or food allergen triggers. She was diagnosed with chronic idiopathic urticaria with angioedema, and was treated with a trial of intravenous immunoglobulin immunotherapy, danazol, prednisone and hydroxyzine. Due to ongoing bowel and arthritic complaints, she was started on infliximab infusions and within 2 treatments, she had complete resolution of the angioedema and urticaria, as well as of the bowel and arthritic symptoms. Unfortunately she developed allergic reactions to the infliximab and was switched to another anti-tumor necrosis factor (TNF)-a agent, adalimumab. Since then, she has had no further angioedema or urticaria, and her Crohn's disease has been quiescent. This is the first known case report of chronic idiopathic urticaria with angioedema coexistent with Crohn's disease that was successfully treated with anti-TNF-a agents.

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Increased circulating pro-inflammatory cytokines and imbalanced regulatory T-cell cytokines production in chronic idiopathic urticaria

Cited by 78 publications

References 38 publications

Different Frequencies of Tc17/Tc1 and Th17/Th1 Cells in Chronic Spontaneous Urticaria

Different Frequencies of Tc17/Tc1 and Th17/Th1 Cells in Chronic Spontaneous Urticaria

Effects of omalizumab treatment on serum cytokine concentrations of atopic patients with chronic spontaneous urticaria: a preliminary report

Angioedema associated with Crohnʼs disease: Response to biologics

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