Increased Circulating miR-155 identifies a subtype of preeclamptic patients

Duan, Honglei; Wang, Yuan; Liú, Dan; Cao, Chenrui; Dai, Yimin; Zhao, Guangfeng; Gu, Ning; Zhou, Yan; Zheng, Mingming; Hu, Yali

doi:10.1101/2022.03.23.22272742

Cited by 2 publications

(3 citation statements)

References 29 publications

(43 reference statements)

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“…Recently, through a longitudinal study related to preeclampsia, we reported that about 30% patients who eventually developed preeclampsia show increased serum miR-155 levels as early as at 11–13 +6 gestational week and maintain high level across pregnancy, while serum miR-155 keeps low throughout normal pregnancy without significant changes as the progression of pregnancy. 22 In this study, we demonstrated that the maternal circulating miR-155 levels were elevated and highly correlated with the pl-miR-155 levels in the patients with high pl-miR-155, and miR-155 levels in serum were also significantly increased in pregnant miR-155 pl+ mice, which could be explained by the location of miR-155 overexpression on syncytiotrophoblasts of the placentas. Syncytiotrophoblasts are the largest subpopulation of placental trophoblasts and bathed in maternal blood pool 47 ; so miR-155 could be excreted into the maternal circulation continuously to activate maternal vascular endothelium to result in the manifestation of preeclampsia.…”

Section: Discussionmentioning

confidence: 57%

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Elevated Placental microRNA-155 Is a Biomarker of a Preeclamptic Subtype

Liú

Dai

et al. 2023

Hypertension

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BACKGROUND: Preeclampsia is a complicated syndrome with marked heterogeneity. The biomarker-based classification for this syndrome is more constructive to the targeted prevention and treatment of preeclampsia. It has been reported that preeclamptic patients had elevated miR-155 in placentas or circulation. Here, we investigated the characteristics of patients with high placental miR-155 (pl-miR-155). METHODS: Based on the 95th percentile (P95) of pl-miR-155 in controls, preeclamptic patients were divided into high miR-155 group (≥P95) and normal miR-155 group (<P95). The changes of placental pathology, clinical manifestations, and placental transcriptome of preeclamptic patients were clustered by t-distributed stochastic neighbor embedding and hierarchical clustering analysis. The placental restricted miR-155 overexpression mouse model was constructed, and the phenotype, placental pathology, and transcriptome were evaluated. Furthermore, the therapeutic potential of antagonist of miR-155 was explored by administrating with antagomir-155. RESULTS: About one-third of preeclamptic patients had high pl-miR-155 expression, which was positively correlated with circulating miR-155 levels. These patients could be clustered as 1 group, according to clinical manifestation, placental pathology, or transcriptomes by t-distributed stochastic neighbor embedding and hierarchical clustering analysis. Further, the pregnant mice with placental restricted miR-155 overexpression could simulate the changes of clinical signs, pathology, and transcriptome of placentas in patients with high pl-miR-155. AntagomiR-155 treatment relieved the preeclampsia-like phenotype and improved the placental vascular development in mice. CONCLUSIONS: There is at least 1 type of preeclampsia with upregulated miR-155 presenting more severe clinical manifestations. MiR-155 may be a potential therapeutic target in patients with high pl-miR-155.

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Section: Discussionmentioning

confidence: 57%

“…The serum collection of preeclamptic patients were collected at admission to our hospital, and the controls were collected during the routine prenatal examinations as previously described. 22…”

Section: Human Serum Sample Collectionmentioning

confidence: 99%

Elevated Placental microRNA-155 Is a Biomarker of a Preeclamptic Subtype

Liú

Dai

et al. 2023

Hypertension

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“…In addition, miR-155 and miR-210, which are upregulated in IH-exposed male subjects, are also increased in preeclampsia, and serve as predictive biomarkers for preeclampsia development [146,147]. miR-144, however, is downregulated in preeclamptic placentas and plays a protective role by inhibiting pro-apoptotic phosphatase and tensin homolog (PTEN) [148].…”

Section: Gestational Ih and Immune Activation During Pregnancymentioning

confidence: 99%

Obstructive Sleep Apnea-Associated Intermittent Hypoxia-Induced Immune Responses in Males, Pregnancies, and Offspring

Song,

Baker,

Watters

et al. 2024

IJMS

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Obstructive sleep apnea (OSA), a respiratory sleep disorder associated with cardiovascular diseases, is more prevalent in men. However, OSA occurrence in pregnant women rises to a level comparable to men during late gestation, creating persistent effects on both maternal and offspring health. The exact mechanisms behind OSA-induced cardiovascular diseases remain unclear, but inflammation and oxidative stress play a key role. Animal models using intermittent hypoxia (IH), a hallmark of OSA, reveal several pro-inflammatory signaling pathways at play in males, such as TLR4/MyD88/NF-κB/MAPK, miRNA/NLRP3, and COX signaling, along with shifts in immune cell populations and function. Limited evidence suggests similarities in pregnancies and offspring. In addition, suppressing these inflammatory molecules ameliorates IH-induced inflammation and tissue injury, providing new potential targets to treat OSA-associated cardiovascular diseases. This review will focus on the inflammatory mechanisms linking IH to cardiovascular dysfunction in males, pregnancies, and their offspring. The goal is to inspire further investigations into the understudied populations of pregnant females and their offspring, which ultimately uncover underlying mechanisms and therapeutic interventions for OSA-associated diseases.

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Increased Circulating miR-155 identifies a subtype of preeclamptic patients

Cited by 2 publications

References 29 publications

Elevated Placental microRNA-155 Is a Biomarker of a Preeclamptic Subtype

Elevated Placental microRNA-155 Is a Biomarker of a Preeclamptic Subtype

Obstructive Sleep Apnea-Associated Intermittent Hypoxia-Induced Immune Responses in Males, Pregnancies, and Offspring

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