Increased cingulo-orbital connectivity is associated with violent behaviours in schizophrenia

Athanassiou, Maria; Dumais, Alexandre; Tikàsz, Andràs; Lipp, Olivier; Dubreucq, Jean-Luc; Potvin, Stéphane

doi:10.1016/j.jpsychires.2022.01.001

Cited by 9 publications

(8 citation statements)

References 54 publications

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“…This triggered off the compressing or blocking of the transmitted information in varying degrees, explaining the functional deactivation state of OFC. The same decreased fALFF value in the LOFC was also found in patients with impulsive SZ ( 30 ). The impaired OFC decreased the inhibitory control mechanism through GABAergic neurons, and the change of OFC might lead to the delay of impulse inhibition ( 18 ).…”

Section: Discussionsupporting

confidence: 68%

“…Structural magnetic resonance imaging (MRI) studies suggested that patients with SZ who were more impulsive showed larger gray and white matter volumes, as well as a smaller cortical thickness in the OFC area compared with those with no history of impulsivity ( 10 , 29 ). Functional MRI studies revealed that patients with impulsivity showed anomalous functional connections between the OFC and anterior cingulate gyrus ( 19 , 30 ). In addition, several MRI studies demonstrated that the reduced gray matter volume in OFC is negatively correlated with the severity of emotional instability, and an abnormal OFC function has also been shown to be associated with the expressions of negative emotions, such as anxiety and fear in patients with SZ ( 4 , 6 , 31 , 32 ).…”

Section: Introductionmentioning

confidence: 99%

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Aberrant Functional Connectivity of the Orbitofrontal Cortex Is Associated With Excited Symptoms in First-Episode Drug-Naïve Patients With Schizophrenia

Chen

Yao

et al. 2022

Front. Psychiatry

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BackgroundSchizophrenia (SZ) is associated with the highest disability rate among serious mental disorders. Excited symptoms are the core symptoms of SZ, which appear in the early stage, followed by other stages of the disease subsequently. These symptoms are destructive and more prone to violent attacks, posing a serious economic burden to the society. Abnormal spontaneous activity in the orbitofrontal cortex had been reported to be associated with excited symptoms in patients with SZ. However, whether the abnormality appears in first-episode drug-naïve patients with SZ has still remained elusive.MethodsA total of 56 first-episode drug-naïve patients with SZ and 27 healthy controls underwent resting-state functional magnetic resonance imaging (rs-fMRI) and positive and negative syndrome scale (PANSS). First, differences in fractional amplitude of low-frequency fluctuations (fALFF) between first-episode drug-naïve patients with SZ and healthy controls were examined to identify cerebral regions exhibiting abnormal local spontaneous activity. Based on the fALFF results, the resting-state functional connectivity analysis was performed to determine changes in cerebral regions exhibiting abnormal local spontaneous activity. Finally, the correlation between abnormal functional connectivity and exciting symptoms was analyzed.ResultsCompared with the healthy controls, first-episode drug-naïve patients with SZ showed a significant decrease in intrinsic activity in the bilateral precentral gyrus, bilateral postcentral gyrus, and the left orbitofrontal cortex. In addition, first-episode drug-naïve patients with SZ had significantly reduced functional connectivity values between the left orbitofrontal cortex and several cerebral regions, which were mainly distributed in the bilateral postcentral gyrus, the right middle frontal gyrus, bilateral paracentral lobules, the left precentral gyrus, and the right median cingulate. Further analyses showed that the functional connectivity between the left orbitofrontal cortex and the left postcentral gyrus, as well as bilateral paracentral lobules, was negatively correlated with excited symptoms in first-episode drug-naïve patients with SZ.ConclusionOur results indicated the important role of the left orbitofrontal cortex in first-episode drug-naïve patients with SZ and suggested that the abnormal spontaneous activity of the orbitofrontal cortex may be valuable to predict the occurrence of excited symptoms. These results may provide a new direction to explore the excited symptoms of SZ.

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Section: Discussionsupporting

confidence: 68%

Section: Introductionmentioning

confidence: 99%

Aberrant Functional Connectivity of the Orbitofrontal Cortex Is Associated With Excited Symptoms in First-Episode Drug-Naïve Patients With Schizophrenia

Chen

Yao

et al. 2022

Front. Psychiatry

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“…As such, fALFF is a normalized version of ALFF and is less susceptible to artifactual signals in regions located within the vicinity of vessels and/or significant pulsatile motion (23). Although many previous studies have found ALFF alternations in schizophrenia, including increased or decreased ALFF in the cingulate gyrus, temporal gyrus, lentiform nuclei, inferior parietal lobes and frontal gyrus (24)(25)(26)(27), few studies have been carried out in schizophrenia patients with PNS. ReHo assumes that a given voxel is temporally similar to those of its neighbors, and can be used to detect the localized functional connectivity or synchronization of information processing with little interference from external stimuli (28).…”

Section: Introductionmentioning

confidence: 99%

Meta-analysis of structural and functional brain abnormalities in schizophrenia with persistent negative symptoms using activation likelihood estimation

et al. 2022

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BackgroundPersistent negative symptoms (PNS) include both primary and secondary negative symptoms that persist after adequate treatment, and represent an unmet therapeutic need. Published magnetic resonance imaging (MRI) evidence of structural and resting-state functional brain abnormalities in schizophrenia with PNS has been inconsistent. Thus, the purpose of this meta-analysis is to identify abnormalities in structural and functional brain regions in patients with PNS compared to healthy controls.MethodsWe systematically searched PubMed, Web of Science, and Embase for structural and functional imaging studies based on five research methods, including voxel-based morphometry (VBM), diffusion tensor imaging (DTI), functional connectivity (FC), the amplitude of low-frequency fluctuation or fractional amplitude of low-frequency fluctuation (ALFF/fALFF), and regional homogeneity (ReHo). Afterward, we conducted a coordinate-based meta-analysis by using the activation likelihood estimation algorithm.ResultsTwenty-five structural MRI studies and thirty-two functional MRI studies were included in the meta-analyses. Our analysis revealed the presence of structural alterations in patients with PNS in some brain regions including the bilateral insula, medial frontal gyrus, anterior cingulate gyrus, left amygdala, superior temporal gyrus, inferior frontal gyrus, cingulate gyrus and middle temporal gyrus, as well as functional differences in some brain regions including the bilateral precuneus, thalamus, left lentiform nucleus, posterior cingulate gyrus, medial frontal gyrus, and superior frontal gyrus.ConclusionOur study suggests that structural brain abnormalities are consistently located in the prefrontal, temporal, limbic and subcortical regions, and functional alterations are concentrated in the thalamo-cortical circuits and the default mode network (DMN). This study provides new insights for targeted treatment and intervention to delay further progression of negative symptoms.Systematic review registration[https://www.crd.york.ac.uk/prospero/], identifier [CRD42022338669].

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“… 41 Another study found that increased functional connectivity in the left OFC and anterior cingulate gyrus was associated with violent behaviour in schizophrenia. 42 These findings all suggest a closer relationship between the left OFC and schizophrenia, but to our knowledge, no study has explored the relationship between H-shaped sulci volume and schizophrenia.…”

Section: Discussionmentioning

confidence: 94%

Childhood trauma and cognitive deficits in patients with schizophrenia: mediation by orbitofrontal cortex H-shaped sulci volume

Wang¹,

Yin²,

Feng³

et al. 2022

jpn

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Background: A line of evidence has shown that childhood trauma and patterns of H-shaped sulci in the orbitofrontal cortex (OFC) are associated with cognitive deficits in patients with schizophrenia. Studies have also suggested that childhood trauma is associated with OFC volumetrics. This study investigated the interrelationship between childhood trauma, OFC H-shaped sulci volume and cognitive function in patients with first-episode schizophrenia. We hypothesized that OFC H-shaped sulci volume would mediate the relationship between childhood trauma and cognitive function in patients with first-episode schizophrenia. Methods: We recruited patients with first-episode schizophrenia ( n = 63) and healthy controls ( n = 48), and quantified OFC H-shaped sulci volumes with 3.0 T high-resolution MRI. We assessed cognitive function and childhood trauma experiences using the MATRICS Consensus Cognitive Battery (MCCB) and the Childhood Trauma Questionnaire (CTQ). Results: Patients with first-episode schizophrenia had smaller left OFC H-shaped sulci volumes, more severe childhood trauma experiences and worse cognitive function than healthy controls. CTQ total score and emotional and physical neglect subscores were negatively correlated with left OFC H-shaped sulci volume. CTQ total score and emotional neglect and sexual abuse subscores were negatively correlated with cognitive function in patients with first-episode schizophrenia. Interestingly, the CTQ total score and physical neglect subscore were positively correlated with cognitive function in healthy controls. Left OFC H-shaped sulci volume played a mediating role in CTQ emotional neglect subscore, CTQ total score and MCCB composite score. Limitations: The small sample size and retrospective design need to be considered. Conclusion: Childhood trauma might contribute to cognitive deficits in patients with first-episode schizophrenia by affecting left OFC H-shaped sulci volume. This finding can help in the design of strategies to improve cognitive function in patients with first-episode schizophrenia.

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Increased cingulo-orbital connectivity is associated with violent behaviours in schizophrenia

Cited by 9 publications

References 54 publications

Aberrant Functional Connectivity of the Orbitofrontal Cortex Is Associated With Excited Symptoms in First-Episode Drug-Naïve Patients With Schizophrenia

Aberrant Functional Connectivity of the Orbitofrontal Cortex Is Associated With Excited Symptoms in First-Episode Drug-Naïve Patients With Schizophrenia

Meta-analysis of structural and functional brain abnormalities in schizophrenia with persistent negative symptoms using activation likelihood estimation

Childhood trauma and cognitive deficits in patients with schizophrenia: mediation by orbitofrontal cortex H-shaped sulci volume

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