Increased chromosome translocations and aneuploidy in peripheral blood lymphocytes of patients having revision arthroplasty of the hip

Doherty, Ann; Howell, R T; Ellis, Lyndon A.; Bisbinas, Ilias; Learmonth, Ian D.; Newson, Roger; Case, C. P.

doi:10.1302/0301-620x.83b7.10102

Cited by 89 publications

(19 citation statements)

References 26 publications

(24 reference statements)

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“…In vitro studies have clearly demonstrated that cobalt particles can be highly cytotoxic when produced in high enough concentrations (Merritt and Brown 1993). There is also much concern about the effect of long-term exposure and the potential for chromosomal aberrations in the patient, as well as the risk of passing chromosomal abnormalities to the next generation (Case et al 1996, Doherty et al 2001, Ladon et al 2004, Bordner et al 2004a, Papageorgiou et al 2007, Ziaee et al 2007). …”

Section: Discussionmentioning

confidence: 99%

Cobalt ions induce chemokine secretion in a variety of systemic cell lines

et al. 2010

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Background and purposeMetal ion toxicity both locally and systemically following MoM hip replacements remains a concern. Cobalt ions have been shown to induce secretion of proinflammatory chemokines locally; however, little is known about their effect systemically. We investigated the in vitro effect of cobalt ions on a variety of cell lines by measuring production of the proinflammatory chemokines IL-8 and MCP-1.MethodRenal, gastrointestinal, and respiratory epithelium and also neutrophils and monocytes were exposed to cobalt ions at 4, 12, 24, and 48 hours.ResultsWe found that cobalt ions enhanced the secretion of IL-8 and MCP-1 in renal epithelial cells, gastric and colon epithelium, monocytes and neutrophils, and small airway epithelial cells but not in alveolar cells. Secretion of IL-8 and MCP-1 was markedly elevated in renal epithelium, where a 16-fold and 7-fold increase occurred compared to controls. There was a 6-fold and 4-fold increase in IL-8 and MCP-1 secretion in colon epithelium and a 4-fold and 3-fold increase in gastric epithelium. Small airway epithelial cells showed a maximum increase in secretion of 8-fold (IL-8) and of 4-fold (MCP-1). The increase in chemokine secretion observed in alveolar cells was moderate and did not reach statistical significance. Monocytes and neutrophils showed a 2.5-fold and 2-fold increase in IL-8 secretion and a 6-fold and 4-fold increase in MCP-1 secretion at 48 and 24 hours, respectively.InterpretationThese data demonstrate the potent bioactivity of cobalt ions in a variety of cell types and the potential to induce a proinflammatory response.

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Section: Discussionmentioning

confidence: 99%

Cobalt ions induce chemokine secretion in a variety of systemic cell lines

et al. 2010

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“…Bone marrow adjacent to the worn implant was found to show an increased number of chromatid breaks and gaps (Case et al 1996). At revision THA, patients with mixed types of CoCr prostheses had a 2.5-fold increase in peripheral blood lymphocytes with aneuploidy and 3.5 fold more chromosomal translocations than at primary THA (Doherty et al 2001). Wear debris from worn hip and knee prostheses in human tissue cultures has been found to damage chromosomes in a dose-dependent manner, which was specific to the type of metal.…”

Section: Introductionmentioning

confidence: 96%

Cancer risk is not increased after conventional hip arthroplasty

Visuri¹,

Pulkkinen

Paavolainen³

et al. 2010

Acta Orthopaedica

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Background and purposeWear debris from conventional total hip arthroplasty (THA) induces chromosomal aberrations and DNA damage, which may promote cancerogenesis. A long latent period is required for solid tumors. We therefore re-analyzed a large THA cohort for cancer.Patients and methodsWe updated a cohort of 24,636 patients with primary osteoarthritis and metal-on-polyethylene THA who had been entered in the Finnish Arthroplasty Register between 1980 and 1995, and linked it to the Finnish Cancer Registry for cancer risk assessment up to 2005. The mean follow-up time was 13 years. The numbers of cancer cases observed were compared with expected rates based on incidence in the general population.ResultsThe standardized incidence ratio (SIR) for the whole follow-up period was 0.95 (95% confidence interval (CI): 0.92–0.97). After 10 years of follow-up, the SIR was equal to that in the normal population (SIR = 0.98, 95% CI: 0.94–1.03). Incidence of lung cancer was low throughout the follow-up time and that of prostate cancer was slightly elevated. The incidence rates for all other forms of cancer did not deviate significantly from those in the normal population.InterpretationWe found no increased cancer risk in patients with conventional THA after an average of 13 years and up to 25 years of follow-up.

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“…These can lead to pain and removal of the implant. Metal ions in the blood have been shown to change the genetics in some blood cells, 23 although it has been shown that patients with metal-on-metal implants do not have an increased risk of developing cancer compared with the general population. 24 Metal ions can also cross the placenta and be absorbed by a fetus, so metal-on-metal implants are not recommended in women of childbearing age.…”

Section: Metal-on-metalmentioning

confidence: 99%

Surgical Total Hip Arthroplasty Options for Geriatric Patients

Chen

Pigott

Klatt

2013

Topics in Geriatric Rehabilitation

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Total hip arthroplasty to replace the hip is a very successful surgical procedure. There are different options for patients with regard to total hip arthroplasty surgical approaches and implant materials. This article provides an in-depth review of the pros and cons of various surgical approaches, including the posterior, lateral, anterior, anterolateral, and transtrochateric approaches. Various implant materials, including metal, ceramic, and polyethylene, are also discussed. and resurfaces the acetabulum. A metal stem is introduced into the femur and a head is placed on top of this stem to replace the femoral head. The acetabular cup is placed into the pelvis and a liner is snapped into this to mate with the head. The goal of placing these implants is to recreate a more normal joint articulation with less friction and less stiffness. This restores function and relieves the pain associated with hip osteoarthritis.THA for hip osteoarthritis is one of the most successful surgical procedures performed, with regard to patient improvement in function and quality of life. 2 While the results of most THAs are good, there are different surgical styles and materials that are used to perform THAs. The purpose of this article was to give an overview of the advantages and disadvantages of different surgical approaches (posterior, lateral, anterolateral, anterior, and transtrochanteric) and different implant materials (metal-on-metal, metal-on-polyethylene, ceramic-on-ceramic, and ceramicon-polyethylene).

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Increased chromosome translocations and aneuploidy in peripheral blood lymphocytes of patients having revision arthroplasty of the hip

Cited by 89 publications

References 26 publications

Cobalt ions induce chemokine secretion in a variety of systemic cell lines

Cobalt ions induce chemokine secretion in a variety of systemic cell lines

Cancer risk is not increased after conventional hip arthroplasty

Surgical Total Hip Arthroplasty Options for Geriatric Patients

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