Increased chromium and nickel content in lung tissue and bronchial carcinoma

Kollmeier, H.; Seemann, J.; Müller, Klaus‐Michael; Rothe, G; Wittig, Peter; Schejbal, V.

doi:10.1002/ajim.4700110607

Cited by 27 publications

(19 citation statements)

References 11 publications

(4 reference statements)

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“…However, considering the relatively small number oftest subjects and the considerable interindividual variation, evidence at present is not sufficient to reach a conclusion that the nickel detected in the lung tissue is a major contributory cause of the development of occupational lung cancer (31). Therefore, investigations using larger numbers of subjects are necessary to understand this relationship.…”

Section: Accumulation Of Nickel In Human Lungsmentioning

confidence: 98%

Risk assessment of nickel carcinogenicity and occupational lung cancer.

Shen

Zhang

1994

Environ Health Perspect

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Recent progress in risk assessment of nickel carcinogenicity and its correlation with occupational lung cancer in nickelexposed workers is reviewed. Epidemiological investigations provide reliable data indicating the close relation between nickel exposure and high lung cancer risk, especially in nickel refieries. The nickel species-specific effects and the doseresponse relationship between nickel exposure and lung cancer are among the main questions that are explored extensively. It is also suggested that some confounding factors such as cigarette smoking cannot be neglected. The determination of nickel concentration in lung tissue may be conducive to estimating the nickel exposure level, but it is uncertain whether the high nickel content in lung tissue indicates high lung cancer risk in nickel-exposed workers. Immunologic studies suggest that the suppressive effect ofnickel on NK cell activity and interferon production may also be involved in the mechanisms of nickel carcinogenesis. As a potential mutagen, nickel can cause chromosome damage both in vitro and in vivo; and on a molecular basis, nickel is found to induce DNA damage (DNA strandbreaks and crosslinks, infidelity of DNA replication, inhibition ofDNA repair, and the helical transition ofB-DNA toZ-DNA) by binding ofnickel ions to DNA and nuclear proteins. The discovery of oncogene promises both a challenge and an opportunity for nickel carcinogenesis research. It can be predicted that, with the rapid development ofmolecular biology and oncology, new approaches will be established for both understanding and controlling nickel-induced occupational lung cancer.

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Section: Accumulation Of Nickel In Human Lungsmentioning

confidence: 98%

Risk assessment of nickel carcinogenicity and occupational lung cancer.

Shen

Zhang

1994

Environ Health Perspect

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“…Determining of total concentrations of the TE in serum and tissues is unlikely to be a sufficiently sensitive or specific marker. What might bring about a change in our knowledge is the speciation of the various forms of trace element found in the organism in relation to lung cancer [4][5][6][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

“…The role of trace elements in the development or inhibition of cancer is still unclear, and numerous investigations have been carried out on this subject [4,5,[8][9][10][11][12][13][14][15][16][17][18][19]. Many of these studies have focused on heavy elements inducing carcinogenity.…”

Section: Introductionmentioning

confidence: 99%

A Discriminant Analysis of Trace Elements in Scalp Hair of Healthy Controls and Stage-IIIB Non-small Cell Lung Cancer (NSCLC) Patients

Cihan

Yıldırım

2011

Biol Trace Elem Res

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Our work aimed at extending the search for the trace elements (TE) abnormalities in patients with lung cancer and in healthy controls who smoke, and also for evidence of a possible association between lung cancer and TE. The analysis of the hair from patients with Stage-IIIB non-small cell lung cancer (group 1) and healthy controls (group 2) were analyzed using the inductively coupled plasma mass spectrometry technique in order to obtain information on the correlation between the lung cancer patients and healthy controls. Sixty-seven one-hair samples in group 1 were individually collected before chemoradiotherapy. For comparison, 74 hair samples were collected from group 2. In group 1, the trace elements present at the highest levels were measured to be Ca, Zn, Sn, Na and Mg, respectively, and they were quantified as 68.2, 53.2, 33.9, 23.3, and 28.9 μg.kg(-1), respectively. In group 2, the trace elements present at the highest levels were Zn, Mg, Ca, Fe, and Se, respectively, and they were quantified as 109.7, 31.9, 30.8, 25.0, and 20.1 μg.kg(-1). In group 1, the highest levels of Ca, Sn, and Na were 2.03, 1.06, and 1.01 times higher, respectively, compared with group 2. In group 2, Zn, Mg, Fe, and Se were 2, 1.01, 2.7, and 1.6 times higher, respectively, compared with group 1. When the levels of trace elements were compared between groups 1 and 2 using Student's t test, the levels of Ag, Au, Be, Bi, Ca, Cd, Ce, Co, Cr, Cu, Fe, Ga, Hg, K, Ni, Rb, Rh, Sb, Sc, Ti, V, and Zn were found to be statistically different (p < 0.05). According to Pearson's correlation, the most powerful correlation was found for Cr-As (r = 0.858) couple in group 1 (r = 0.745) and for Mn-Cr couple in group 2. The factors obtained according to converted matrix were observed to be as follows: for group 1, first factor, ten variables (Cd, Li, Cs, Ag, Rb, Pd, Ga, Zn, Al, and K); second factor, seven variables (Cr, As, Sn, Co, Ca, Rh, and Fe) and third factor, four variables (Mn, Au, Cu, and Hg). Within the first factor that best describes the overall change, the most important variables are Cd and Li, respectively the first and the second factors. Group 2 contained the following: first factors, six variables, Cr, Mn, Al, Ba, Rb, and Pb; second factor, eight variables, Co, As, Sn, Cd, Hg, Cs, Ca, and Ce; third factor, five variables Na, Ga, Be, B, and Sr; and fourth factor, two variables K and Ag. First, second, third, and fourth factors explain the 36% of the overall change. Within the first factor that best described the overall change, the most important variables were Cr and Mn. In this analysis, we observed that the group 2 trace elements accumulated were heavy metals and that the control group showed both heavy metals and macroelements required for the body. The average trace elements levels in the two groups were evaluated. In addition, the general role of trace elements in the lung carcinogenic processes was discussed. The study revealed that the carcinogenic processes are significantly affecting the trace elements and the trace elements...

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“…Serum Cu levels were found to be lower in lung cancer patients than in healthy people [2]. Levels of Ni were found to be increased in 15 patients with breast cancer [3].…”

Section: Introductionmentioning

confidence: 99%

“…In a study on colorectal cancer patients, varying levels of Fe, Cu, Mn and S were found [1][2][3][4]. Levels of Na, Mg, Ca, Se, Rb and Mo were observed to decrease in the plasma of lung cancer patients undergoing radiotherapy.…”

Section: Introductionmentioning

confidence: 99%