Increased CD69 Expression on Peripheral Eosinophils from Patients with Food Protein-Induced Enterocolitis Syndrome

Wada, Taizo; Matsuda, Yusuke; Toma, Tomoko; Koizumi, Eiko; Okamoto, Hiroyuki; Yachie, Akihiro

doi:10.1159/000448755

Cited by 16 publications

(4 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, both the rise of peripheral platelets and neutrophils might also be linked to the associated stress and their active contribution needs to be determined. Non‐specific presence of eosinophils have also been reported in FPIES patients (increase expression of CD69, clusters of eosinophils in intestinal biopsies and eosinophils/Charcot‐Leyden crystals in stool samples) . A potential role of mast cells was suggested, as higher baseline tryptase levels within the normal range were found in children with CM‐FPIES compared to controls .…”

Section: Different Phenotypes Of Food Protein‐induced Enterocolitis Smentioning

confidence: 88%

“…Non-specific presence of eosinophils have also been reported in FPIES patients (increase expression of CD69, clusters of eosinophils in intestinal biopsies and eosinophils/Charcot-Leyden crystals in stool samples). 55,56 A potential role of mast cells was suggested, as higher baseline tryptase levels within the normal range were found in children with CM-FPIES compared to controls. 4 These data need to be confirmed by further studies.…”

Section: Pathophysiology Of Food Protein-induced Enterocolitis Syndmentioning

confidence: 99%

See 1 more Smart Citation

Food protein‐induced enterocolitis syndrome

Caubet

Cianferoni

Groetch

et al. 2019

Clin Experimental Allergy

View full text Add to dashboard Cite

Food protein‐induced enterocolitis syndrome (FPIES) is a non‐IgE‐mediated gastrointestinal food allergic disorder that has gained a major interest the past decade. FPIES prevalence, which still needs to be accurately determine in different populations, appears to be higher than previously thought (ie up to 0.7% in infants in the 1st year of life). FPIES to seafood in adults is also increasingly reported; limited data suggest that adult FPIES is most commonly triggered by shellfish, tends to affect females more than men, is characterized by a significant delay in diagnosis and a prolonged course. The first international consensus guidelines on diagnosis and management of FPIES have been published in 2017, proposing new diagnostic criteria as well as new criteria for a positive oral food challenge. However, there is a need to develop new biomarkers to improve the diagnosis and management of FPIES patients, and this requires a better understanding of the pathophysiology. Recently, the role of T cells has been questioned and a major role of innate immune cells has been suggested in acute FPIES. Regarding the treatment of acute FPIES reaction, ondansetron has emerged as an adjunct to intravenous rehydration in moderate‐severe reactions and as a first‐line treatment in mild reactions. Important information regarding the nutritional management of FPIES patients that might be complex has also been provided in the international guidelines. In this review, we discuss recent advances regarding all those different aspects.

show abstract

Section: Different Phenotypes Of Food Protein‐induced Enterocolitis Smentioning

confidence: 88%

Section: Pathophysiology Of Food Protein-induced Enterocolitis Syndmentioning

confidence: 99%

Food protein‐induced enterocolitis syndrome

Caubet

Cianferoni

Groetch

et al. 2019

Clin Experimental Allergy

View full text Add to dashboard Cite

show abstract

“…Two years later, the same researchers explored the expression of activation marker CD69 on circulating eosinophils from five patients with FPIES [ 95 ]. Consistent with their previous report [ 94 ], a significant increase in fecal EDN on the day after ingestion of the causative food was observed in all patients (mean 26,670 ng/mL), with a median time to maximum concentration of 30 h [ 95 ].…”

Section: Resultsmentioning

confidence: 99%

Emerging Role of Alarmins in Food Allergy: An Update on Pathophysiological Insights, Potential Use as Disease Biomarkers, and Therapeutic Implications

Rizzi

Presti

Chini

et al. 2023

JCM

View full text Add to dashboard Cite

Food allergies are immuno-mediated adverse reactions to ingestion or contact with foods, representing a widespread health problem. The immune response can be IgE-mediated, non-IgE-mediated, or with a mixed mechanism. The role of innate immunity and alarmins in the pathogenesis of diseases such as asthma and atopic dermatitis is well known. Some authors have investigated the correlation between alarmins and food allergies, often obtaining interesting results. We analyzed articles published in English from the last 22 years present on PubMed concerning the role of alarmins in the pathogenesis of food allergies and their potential use as disease biomarkers, response biomarkers to therapy, or potential therapeutic targets. Nuclear alarmins (TSLP, IL-33, IL-25) appear to have a critical role in IgE-mediated allergies but are also implicated in entities such as eosinophilic esophagitis. Calprotectin and defensins may play a role as disease biomarkers and could help predict response to therapy, although results in the literature are often conflicting. Despite the promising results, more studies on humans still need to be conducted. Deepening our knowledge regarding alarmins and their involvement in food allergies could lead to the development of new biological therapies, significantly impacting patients’ quality of life.

show abstract

“…In acute reactions of food protein-induced enterocolitis syndrome, an increased expression of CD69 on eosinophils has been noted, though the absolute eosinophil counts in the peripheral blood were not increased, suggesting CD69 as a marker for systemic events in the disease [56]. If patients on oral or sublingual immunotherapy develop gastrointestinal symptoms, they should be evaluated by endoscopy for eosinophilic gastrointestinal disorders [57].…”

Section: Improving the Diagnosis And Treatment Of Food Allergymentioning

confidence: 99%

Recent Advances in Clinical Allergy and Immunology

Simon

2018

Int Arch Allergy Immunol

View full text Add to dashboard Cite

Allergic diseases are of great concern because of their high prevalence, which is still rising in several regions, their impact on patients’ physical and psychological health, the huge burden they place on patients’ quality of life, as well as the socioeconomic consequences that they cause. Recent research has provided new data on both genetic and environmental risk factors of atopic/allergic diseases. The application of new technologies such as “omics” has allowed a better understanding of the pathogenesis and has helped with the identification of therapeutic targets. Immense progress has been made in developing and applying novel, targeted therapies, for example for asthma and urticaria. Intensive efforts are being made to find biomarkers that help to classify patients, to identify their potential responsiveness to specific therapies, and to monitor the disease severity. Based on recent insights in the pathogenesis of food allergy and drug hypersensitivity, novel strategies for diagnostics, allergen avoidance, and induction of tolerance have been developed. Here, we summarize important findings in the field of clinical allergy and immunology with a special focus on asthma, allergic rhinitis, atopic dermatitis, food allergy, urticaria, angioedema, and drug hypersensitivity.

show abstract

Increased CD69 Expression on Peripheral Eosinophils from Patients with Food Protein-Induced Enterocolitis Syndrome

Abstract: Background: Food protein-induced enterocolitis syndrome (FPIES) is an uncommon,

Cited by 16 publications

References 18 publications

Food protein‐induced enterocolitis syndrome

Food protein‐induced enterocolitis syndrome

Emerging Role of Alarmins in Food Allergy: An Update on Pathophysiological Insights, Potential Use as Disease Biomarkers, and Therapeutic Implications

Recent Advances in Clinical Allergy and Immunology

Contact Info

Product

Resources

About