Increased Carotid Intima-Media Thickness in Female Patients With Fibromyalgia: A Preliminary Study

Bölük, Hüma

doi:10.5606/archrheumatol.2015.5639

Cited by 8 publications

(11 citation statements)

References 29 publications

(29 reference statements)

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“…In the literature, studies have shown the presence of early atherosclerosis with increased CIMT values in ankylosing spondylitis, rheumatoid arthritis and Behçet's disease compared to a healthy population (26,27). In addition, high serum endocan levels and increased CIMT in patients with FMS have been shown in different studies (28,29) . Previous studies have reported that endocan levels and CIMT are correlated in inflammatory diseases (7,8).…”

Section: Discussionmentioning

confidence: 92%

“…Fibromyalgia syndrome (FMS) is a chronic Pain syndrome characterized by widespread pain, sensitivity, sleep disturbance, fatigue, cognitive dysfunction, and emotional stress (1). Although the pathophysiology of FMS has not yet been completely elucidated, it has been suggested that inflammation and endothelial dysfunction occur in patients with FMS (2,3). Studies have shown that serum levels of proinflammatory cytokines (TNF-a, IL-6) and chemokines (Tarc, MIG) are higher in patients with FMS than in the healthy population (4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

“…Studies have shown that serum levels of proinflammatory cytokines (TNF-a, IL-6) and chemokines (Tarc, MIG) are higher in patients with FMS than in the healthy population (4)(5)(6). Furthermore, carotid intima-media thickness (CIMT) used to evaluate early atherosclerotic vascular diseases has been shown to be increased in FMS patients (2). Some studies have also shown that the level of endocan, which is a novel marker of inflammation and endothelial dysfunction, correlates with CIMT in various inflammatory diseases (7,8).…”

Section: Introductionmentioning

confidence: 99%

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Is There Any Relationship Between Serum Endocan Levels and Carotid Intima-media Thickness in Patients with Fibromyalgia?

Bağcıer¹,

Tufanoğlu²,

Kadıçeşme³

2019

Tod

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Amaç: Fibromiyaljinin patofizyolojisi henüz tam olarak aydınlatılmamış olmakla birlikte, fibromiyaljili hastalarda enflamasyon ve endotel disfonksiyonunun ortaya çıktığı ileri sürülmüştür. Son yıllarda, endokan enflamasyon ve endotel disfonksiyonu için önemli bir biyobelirteç olarak bildirilmiştir. Erken aterosklerotik vasküler hastalıkları değerlendirmede karotis intima media-kalınlığının (KİMK) değerlendirilmesi önemlidir. Bu çalışmada, fibromiyalji hastalarında serum endokan düzeylerini ve KİMK'yi ölçerek bu mekanizmayı araştırdık, aralarında bir korelasyon olup olmadığını değerlendirdik. Gereç ve Yöntem: İlk kez fibromiyalji tanısı alan 40 kadın hastadan toplanan serum örnekleri ve 40 sağlıklı kadın endokan düzeyleri ve KİMK ultrasonografi ile incelendi ve iki grubun değerleri karşılaştırıldı. Bulgular: Hasta grubunda serum endokan seviyeleri ve KİMK sonuçları kontrol grubuna göre anlamlı olarak yüksek olarak bulunmuştur (p<0,001). Ayrıca FMS'li hastalarda KİMK ile endokan seviyesi arasında çok zayıf bir korelasyon görüldü. Sonuç: Fibromiyaljinin patofizyolojisinde artmış subklinik enflamasyon, endotelyal disfonksiyon ve erken ateroskleroz önemlidir. Artan endokan düzeyi, KİMK ve aralarında korelasyon görülmesi bu mekanizmayı aydınlatmaya katkı sağlar.Objective: Although the pathophysiology of Fibromyalgia syndrome (FMS) has not yet been completely elucidated, it has been suggested that inflammation and endothelial dysfunction occur in patients with FMS. In recent years, endocan has been reported as an important biomarker for inflammation and endothelial dysfunction. It is important to assess carotid intima-media thickness (CIMT) in the evaluation of early atherosclerotic vascular diseases. In this study, we investigated this mechanism by measuring serum endocan levels and CIMT in patients with FMS and evaluated whether there is a correlation between them. Materials and Methods: Serum samples collected from 40 female patients diagnosed with FMS (the patient group) for the first time and 40 healthy female participants' (the control group) endocan levels and CIMT ultrasonography were investigated, and the values of the two groups were compared. Results: Serum endocan levels and CIMT results were significantly higher in the patient group than in the control group (p<0.001). In addition, a very weak correlation was found between CIMT and endocan levels in patients with FMS. Conclusion: Increased subclinical inflammation, endothelial dysfunction, and early atherosclerosis play an important role in the pathophysiology of FMS. Increased endocan levels, CIMT, and the correlation between them will contribute to elucidating this mechanism. Turk J Osteoporos 2019;25:49-52 Abstract

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Section: Discussionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Is There Any Relationship Between Serum Endocan Levels and Carotid Intima-media Thickness in Patients with Fibromyalgia?

Bağcıer¹,

Tufanoğlu²,

Kadıçeşme³

2019

Tod

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“…Neuroendocrine abnormalities including autonomic dysfunction were thought to play an important role in the pathogenesis of the disease [3,4]. Autonomic dysfunction characterized by sympathetic hyperactivation and/or parasympathetic dysfunction in FMS patients has been shown to be related to many cardiovascular diseases including arrhythmias, and suggested to be the cause of increased cardiovascular mortality and morbidity [5][6][7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Subclinical cardiac structural and electrical abnormalities in fibromyalgia syndrome

et al. 2020

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Background/aim: In the literature, there is a paucity of data about the effects of fibromyalgia syndrome (FMS) on myocardial function and electrophysiological properties of atrium and ventricles. In this study, we investigated cardiac functions and noninvasive predictors of arrhythmias in patients with FMS. Materials and methods: The study included 43 female patients diagnosed with FMS and 30 age-and sex-matched healthy subjects. The presence of fragmented QRS (fQRS) morphology, P dispersion, QT dispersion, inter-and intraatrial electromechanical delay was evaluated in the groups with 12-lead ECG and standard and tissue Doppler echocardiography. Results: Among electrocardiographic parameters, P dispersion, QT dispersion, and the ratio of presence of fQRS morphology were found to be significantly higher in the study group as compared to the control group. In lateral and septal, the ratio of the early transmitral flow velocity to the early diastolic tissue velocity (E/Em) was significantly higher in the study group. Additionally, intra-and interatrial electromechanical delay was found significantly prolonged in the study group. Conclusion: FMS is found to be associated with significant cardiac electrical alterations that may indicate the increased risk of atrial and ventricular arrhythmias in this group of patients.

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“…1,2 Previous studies have established that FM is associated with cardiovascular diseases such as nondipper circadian blood pressure variability, increased carotid intima media thickness, and coronary heart disease. [3][4][5] Although the exact physiopathology is not known, the aforementioned studies mainly focused on inappropriate sympathetic discharges due to the autonomic nervous system changes and their impacts on blood pressure and cardiac functions. On the other hand, diastolic dysfunction (DD) refers to a collection of mechanical problems in the contraction and relaxation of the heart.…”

mentioning

confidence: 99%

Evaluation of Ventricular Diastolic Function in Patients With Fibromyalgia Syndrome

Sayılır

Ergün

Ekiz³

2018

Arch Rheumatol

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Objectives:This study aims to compare the diastolic functions between fibromyalgia (FM) patients and control subjects by using transthoracic echocardiography. Patients and methods:This case-control and cross-sectional study included 34 female FM patients (mean age 43.6±8.2 years; range 28 to 57 years), who were diagnosed by The American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia and defined as the FM group. A control group was defined consisting of 30 healthy females (mean age 41.2±9.1 years; range 22 to 54 years). Echocardiography findings of the groups were compared. Results: The body mass index and mean disease duration of the FM group were 25.37±2.71 kg/m 2 and 12.24 months, respectively. The body mass index of the control group was 25.58±1.49 kg/m 2 . There was no significant difference between the groups in terms of age and body mass index. Isovolumetric relaxation time and mitral E-wave deceleration time values were significantly higher in the FM group than in the control group (p=0.047, p=0.003, respectively). Conclusion: Isovolumetric relaxation time and mitral valve deceleration time are significantly prolonged in FM patients compared with healthy subjects. Female patients with FM seem to be under risk of impaired relaxation and diastolic function of the left ventricle.

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Increased Carotid Intima-Media Thickness in Female Patients With Fibromyalgia: A Preliminary Study

Cited by 8 publications

References 29 publications

Is There Any Relationship Between Serum Endocan Levels and Carotid Intima-media Thickness in Patients with Fibromyalgia?

Is There Any Relationship Between Serum Endocan Levels and Carotid Intima-media Thickness in Patients with Fibromyalgia?

Subclinical cardiac structural and electrical abnormalities in fibromyalgia syndrome

Evaluation of Ventricular Diastolic Function in Patients With Fibromyalgia Syndrome

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