Increased carotid IMT in overweight and obese women affected by Hashimoto's thyroiditis: an adiposity and autoimmune linkage?

Ciccone, Marco Matteo; Pergola, Giovanni De; Porcelli, Maria T; Scicchitano, Pietro; Caldarola, Pasquale; Iacoviello, Massimo; Guida, Pietro; Giorgino, Francesco; Favale, Stefano

doi:10.1186/1471-2261-10-22

Cited by 62 publications

(53 citation statements)

References 26 publications

(20 reference statements)

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“…The increased risk of atherosclerosis in patients with SCH is usually due to dyslipidemia and hypertension (5), but the results of this study, similar to other ones (22,23,29), showed that SCH is associated with carotid atherosclerosis independent of these factors. Several studies (17,18,30) showed a reduction in CIMT in patients with SCH after treatment with levothyroxine.…”

Section: Discussionsupporting

confidence: 77%

Subclinical hypothyroidism and risk to carotid atherosclerosis

Valentina

Bosevski²,

Chedo³

et al. 2011

Arq Bras Endocrinol Metab

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Objective: The aim of this study was to assess whether subclinical hypothyroidism (SCH) is associated with carotid atherosclerosis, as well as dyslipidemia, and arterial hypertension. Subjects and methods: The study included 69 consecutive patients with newly diagnosed SCH, and 30 matched healthy controls. Body mass index (BMI), TSH, fT4, antibodies to thyroid peroxidase (TPOabs), lipids, blood pressure, mean and maximum carotid intima-media thickness (CIMT) were determined in all participants. Results: Mean values of CIMT, triglycerides, and total cholesterol/HDL-C ratio were significantly different in SCH patients versus matched controls. Linear multiple regression analysis demonstrated that TSH, diastolic blood pressure and triglycerides were independent predictors of mean CIMT, fT4 for maximum CIMT; and that TSH, fT4, age, and total cholesterol/HDL-C ratio were independent predictors of the presence of carotid plaques. Conclusion: Our data revealed that SCH is associated with increase in CIMT and presence of carotid plaques, independent of classical risk factors for atherosclerosis. Arq Bras Endocrinol Metab. 2011;55(7):475-80 Keywords Subclinical hypothyroidism; atherosclerosis; dyslipidemia; arterial hypertension; carotid intima-media thickness ReSumoObjetivo: O objetivo deste estudo foi avaliar se o hipotireoidismo subclínico (HSC) está associado a aterosclerose de carótida, dislipidemia e hipertensão arterial. Sujeitos e métodos: O estudo incluiu 69 pacientes consecutivos recém-diagnosticados com HSC e 30 controles pareados. Índice de massa corpórea, TSH, T4L, anticorpos antiperoxidase (TPO), perfil lipídico, pressão arterial, espessamento carotídeo íntima-média máximo (ECIM) e médio foi determinado em todos os indivíduos. Resultados: Os valores médios de ECIM, triglicérides e razão colesterol total/C-HDL foram significantemente diferentes entre pacientes e controles. Regressão linear múltipla demonstrou que TSH, pressão arterial diastólica e triglicérides foram fatores independentes preditores de ECIM médio, T4L para ECIM máximo e TSH, T4L, idade e colesterol total/HDL-C para presença de placa carotídea. Conclusão: Nossos resultados indicam que HSC é associado com aumento do ECIM e presença de placas carotídeas, independentemente dos fatores de risco clássicos para aterosclerose. Arq Bras Endocrinol Metab. 2011;55(7):475-80 Descritores

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Section: Discussionsupporting

confidence: 77%

Subclinical hypothyroidism and risk to carotid atherosclerosis

Valentina

Bosevski²,

Chedo³

et al. 2011

Arq Bras Endocrinol Metab

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“…Currently, however, the causative relationship between thyroid autoimmunity and increased risk of atherosclerosis has not yet been established. A few studies which were addressing this question investigated the effect of thyroid autoimmunity on lipid profile, abdominal obesity, fasting glucose and homeostasis model assessment (HOMA) insulin resistance, as well as carotid intima-media thickness (CIMT) [25][26][27]. However, in contrast to our study group, the study populations were not uniform, therefore the conclusions of these investigations are not comparable.…”

Section: Discussioncontrasting

confidence: 53%

Serum homocysteine levels are decreased in levothyroxine-treated women with autoimmune thyroiditis

Owecki

Dorszewska

Sawicka‐Gutaj

et al. 2014

EJEA

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Background: Hyperhomocysteinemia is a well-known cardiovascular risk factor and its elevation is established in overt hypothyroidism. Since some authors suggest that chronic autoimmune thyroiditis per se may be considered as a novel risk factor of atherosclerosis independent of thyroid function, the analysis of classical cardiovascular risk factors might be helpful in evaluation the causative relationship. Data concerning the impact of thyroid autoimmunity in euthyroid state on homocysteine (Hcy) level is lacking. The aim of this study was to evaluate Hcy level in context of anti-thyroperoxidase antibodies (TPOAbs) in euthyroidism. Methods: It is a case-control study. 31 euthyroid women treated with levothyroxine (L-T4) due to Hashimoto thyroiditis (HT) and 26 females in euthyroidism without L-T4 replacement therapy were enrolled in the study. All women with HT had positive TPOAbs. Forty healthy females negative for TPOAbs comparable for age and body mass index (BMI) participated in the study as controls. Exclusion criteria were a history of any acute or chronic disease, use of any medications (including oral contraceptives and vitamin supplements), smoking, alcoholism. Results: TPOAbs titers were higher in both groups of HT patients versus the healthy controls. Hcy levels were found to be significantly lower in treated HT patients (Me 11 μmol; IQR 4.2 μmol) as compared with healthy controls (Me 13.35 μmol; IQR 6.34 μmol; p = 0.0179). In contrast, no significant difference was found between non treated HT and control group in Hcy level. The study groups and the controls did not differ in age and BMI. Furthermore, levels of TSH, FT4, TC, LDL, HDL and TAG did not differ between the study group and the control group. Conclusion: The main finding of the study is a decrease in Hcy level in treated HT as compared with healthy controls. Based on our observations one can also assume that correct L-T4 replacement was associated here with a decrease of Hcy. Furthermore, it seems that non treated HT in euthyroidism is not associated with Hcy increase, in contrast to overt hypothyroidism. This may be just another argument against the concepts about the role of "euthyroid HT" in the development of atherosclerosis.

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“…Thyroid damage might also increase the risk of severe autoimmune thyroid disease. All these hypotheses are in line with a recent paper showing that Hashimoto's thyroiditis is associated to an increased intima-media thickness only in overweight and obese subjects, independently of the thyroid function, BMI and cardiovascular risk factors, suggesting that Hashimoto's thyroiditis is a marker of evolution of atherosclerosis whether combined to adiposity [27].…”

Section: Discussionsupporting

confidence: 89%

Possible Evolution of Autoimmune Thyroiditis in Hypothyroidism: Role of Obesity

G¹

2013

OCTOA

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Increased carotid IMT in overweight and obese women affected by Hashimoto's thyroiditis: an adiposity and autoimmune linkage?

Cited by 62 publications

References 26 publications

Subclinical hypothyroidism and risk to carotid atherosclerosis

Subclinical hypothyroidism and risk to carotid atherosclerosis

Serum homocysteine levels are decreased in levothyroxine-treated women with autoimmune thyroiditis

Possible Evolution of Autoimmune Thyroiditis in Hypothyroidism: Role of Obesity

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