Increased Carotid Atherosclerosis in Andropausal Middle-Aged Men

Mäkinen, Juuso; Järvisalo, Mikko J.; Pöllänen, Pasi; Perheentupa, Antti; Irjala, Kerttu; Koskenvuo, Markku; Mäkinen, Juha; Huhtaniemi, Ilpo; Raitakari, Olli T.

doi:10.1016/j.jacc.2005.01.052

Cited by 150 publications

(106 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Similar results were demonstrated in younger men with T levels < 9.8 nmol/mL. 85 In men aged 73-90 years, TT concentrations were inversely correlated with increased carotid intima media thickness (CIMT). 86 In a prospective analysis in 195 independently living older men, FT levels were inversely related to the mean progression of CIMT after adjustment on the usual cardiovascular risk factors; TT concentration were not.…”

Section: Body Composition and Cardiovascular Healthsupporting

confidence: 63%

“…Low T status and metabolic syndrome both appear to be independently associated with increased all-cause and cardiovascular mortality. 28,80,81 Hence, several studies have examined the impact of TT, FT, and SHBG levels on cardiovascular health or atherosclerosis 54,72,[82][83][84][85][86][87] Thus, from the analysis of the large Swedish arm of the cross-sectional Osteoporotic Fractures in Men study (3,014 men aged 69-80 years), Tivesten et al observed that individuals with TT and FT levels within the lowest quartile have an increased odds of lower-extremity peripheral artery disease (i.e., ankle and brachial index < 0.9). 84 Hak et al in the Rotterdam Study have investigated the association of T and FT serum levels with aortic atherosclerosis (i.e., radiographic detection of calcified deposits in the abdominal aorta) among 1,032 nonsmoking men aged 55 year and over.…”

Section: Body Composition and Cardiovascular Healthmentioning

confidence: 99%

See 1 more Smart Citation

Testosterone Replacement Therapy in Reversing “Andropause”: What Is the Proof-of-Principle?

Lang

Samaras

2012

Rejuvenation Research

View full text Add to dashboard Cite

Testosterone replacement therapy is often equated with the macho male physique and virility and is viewed by some as an antiaging tonic. The growth in testosterone's reputation and its increased use by men of all ages has seemed to outpace the scientific evidences. This review will aim to examine the uncertainty regarding the nature and the clinical importance of the age-related reduction in the testosterone levels. Considerations will be given both to clinical symptoms, biochemical and clinical diagnostic criteria, and to the risk-to-benefit ratio of reversing late-onset hypogonadism in aging and older men.

show abstract

Section: Body Composition and Cardiovascular Healthsupporting

confidence: 63%

Section: Body Composition and Cardiovascular Healthmentioning

confidence: 99%

Testosterone Replacement Therapy in Reversing “Andropause”: What Is the Proof-of-Principle?

Lang

Samaras

2012

Rejuvenation Research

View full text Add to dashboard Cite

show abstract

“…Carotid artery intima-media thickness, a common marker of clinical and subclinical atherosclerosis, has been shown to be correlated inversely with testosterone levels. [65][66][67] Demirbag et al 68 reported a similar finding by examining the intima thickness of the thoracic aorta in older men. Similarly, in the Rotterdam Study population, Hak et al 69 demonstrated that both bioavailable and total testosterone levels were negatively associated with calcified deposits in the abdominal aorta in men older than 55 years of age.…”

Section: Association Of Low Testosterone With Surrogate Markers Of Atmentioning

confidence: 65%

Hormonal effects on blood vessels

Akishita

2012

Hypertens Res

View full text Add to dashboard Cite

The incidence of cardiovascular disease (CVD) is lower in younger women than in men of the same age, but it increases after menopause, implicating the atheroprotective action of endogenous estrogen. Although observational studies have suggested the efficacy of estrogen therapy in postmenopausal women, placebo-controlled, randomized trials, such as the Women's Health Initiative, have not confirmed effects of estrogen therapy on CVD. Conversely, basic, experimental research has progressed and provided mechanistic insight into estrogen's action on blood vessels. By contrast, the vascular effects of androgens remain poorly understood and have been controversial for a long time. In recent years, an increasing body of evidence has suggested that androgens may exert protective effects against the development of atherosclerosis, at least in elderly men. Epidemiological studies have shown that the incidence of and mortality due to CVD were increased in elderly men with low testosterone levels, although the efficacy of androgen therapy remains unknown. Furthermore, recent experimental studies have demonstrated the direct action of androgens on the vasculature. In this review, we illustrate the effects of sex steroids on the cardiovascular system, focusing on the action of testosterone on the blood vessels.

show abstract

“…In fact, several in vivo and in vitro studies have suggested that androgens increase expression of proatherogenic factors (Adams et al 1995, McCrohon et al 1999, Ng et al 2003, Nheu et al 2011. In contrast, recent clinical studies have shown that low endogenous testosterone levels are associated with advanced atherosclerosis of the carotid artery in middleaged males and that this association is independent of the traditional cardiovascular risk factors (Muller et al 2004, Makinen et al 2005. Low testosterone level is also associated with poor vasodilation of the brachial artery and is an independent risk factor for endothelial dysfunction in men (Akishita et al 2007).…”

Section: Effects Of Androgens On Vascular Remodelingmentioning

confidence: 99%

Effects of androgens on cardiovascular remodeling

Ikeda

Aihara

Yoshida³

et al. 2012

Journal of Endocrinology

View full text Add to dashboard Cite

Androgens, the male sex hormones, exert various biological effects on many target organs through the transcriptional effects of the nuclear androgen receptor (AR). ARs are expressed not only in classical target organs, such as the brain, genital organs, bone, and skeletal muscles, but also in the cardiovascular system. Because the female sex hormones estrogens are wellknown to protect against cardiovascular disease, sex has been considered to have a significant clinical impact on cardiovascular mortality. However, the influence of androgens on the cardiovascular system has not been fully elucidated. To clarify this issue, we analyzed the effects of administration of angiotensin II and doxorubicin, an anticancer agent, in a loading model in male wild-type and AR-deficient mice. In this review, we focus on the actions of androgens as potential targets for the prevention of cardiovascular diseases in males.

show abstract

Increased Carotid Atherosclerosis in Andropausal Middle-Aged Men

Cited by 150 publications

References 40 publications

Testosterone Replacement Therapy in Reversing “Andropause”: What Is the Proof-of-Principle?

Testosterone Replacement Therapy in Reversing “Andropause”: What Is the Proof-of-Principle?

Hormonal effects on blood vessels

Effects of androgens on cardiovascular remodeling

Contact Info

Product

Resources

About