Increased cardiovascular reactivity to the cold pressor test is not associated with increased reactivity to isometric handgrip exercise

Moriyama, Kayo; Ifuku, Hirotoshi

doi:10.1007/s00421-009-1299-8

Cited by 17 publications

(14 citation statements)

References 29 publications

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“…23,24 Baroreflex resetting also occurs during CPT though only about 120 s after the onset of the cold stimulus. 25 This is consistent with our data, demonstrating that the HR was still under baroreflex control (see Fig. 5 and Table 2).…”

Section: Discussionsupporting

confidence: 94%

Carotid haemodynamics during sympathetic nervous system stimulation via handgrip and cold pressor testing in young healthy subjects: A feasibility study

Londoño

Klopmeijer

Georgakopoulos

et al. 2014

ARTRES

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Introduction: Assessing arterial and haemodynamic properties in response to a physiological perturbation might provide additional information on an individual's "vascular health". The aim of this study was to assess the feasibility of measuring changes in carotid stiffness and haemodynamics in response to sympathetic nervous system stressors, such as the Hand Grip Test (HGT) and the Cold Pressor Test (CPT). Methods: A non-invasive protocol, consisting of two HGT's at 30% and 40% of maximal voluntary contraction and a CPT, was performed in 12 young healthy volunteers (6 males/6 females). Measurements included continuous finger blood pressure recordings (NexFin; non-dominant hand) and ultrasound measurement of common carotid diameter distension and flow velocity at discrete moments in time during the protocol (GE Vivid 7 system). Carotid distension (DD/ D), local wave speed using the waterhammer equation (PWV WH ) and reflection magnitude (RM; ratio of backward to forward diameter wave) were derived from the data. Results: Consistent with the overall increase in blood pressure, carotid diameter increased while DD/D decreased. PWV WH and RM showed high variability during both HGT's and CPT. Conclusion: It is feasible to monitor the carotid haemodynamic response to selected Artery Research (2014) 8, 178e188 sympathetic nervous system stimulus. Moreover, the analysis showed supporting evidence of specific physiological response to regulate adequately each stress stimulus.

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Section: Discussionsupporting

confidence: 94%

Carotid haemodynamics during sympathetic nervous system stimulation via handgrip and cold pressor testing in young healthy subjects: A feasibility study

Londoño

Klopmeijer

Georgakopoulos

et al. 2014

ARTRES

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“…Remembering that the CPT was merely a tool to evoke sympatho-excitation and forearm vasoconstriction, it was important to ensure that this tool did indeed evoke what it was intended to evoke. A lack of participant screening prior to investigation when utilizing the CPT could easily lead to confounded conclusions due to the non-homogeneous response to the CPT within a population (Ifuku et al, 2007; Moriyama and Ifuku, 2007, 2010). Furthermore, we accounted for normal changes in post-exercise blood flow by validation of a curve fit prediction technique that provided good estimates of what the normal FVC would have been during the CPT test.…”

Section: Discussionmentioning

confidence: 99%

Persistence of functional sympatholysis post-exercise in human skeletal muscle

Moynes¹,

Bentley²,

Bravo³

et al. 2013

Front. Physiol.

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Blunting of sympathetic vasoconstriction in exercising muscle is well-established. Whether it persists during the early post-exercise period is unknown. This study tested the hypothesis that it persists in human skeletal muscle during the first 10 min of recovery from exercise. Eight healthy young males (21.4 ± 0.8 yrs, SE) performed 7 min of forearm rhythmic isometric handgrip exercise at 15% below forearm critical force (fCF). In separate trials, a cold pressor test (CPT) of 2 min duration was used to evoke forearm sympathetic vasoconstriction in each of Rest (R), Steady State Exercise (Ex), 2–4 min Post-Exercise (PEearly), and 8–10 min Post-Exercise (PElate). A 7 min control exercise trial with no CPT was also performed. Exercising forearm brachial artery blood flow, arterial blood pressure, cardiac output (CO), heart rate (HR), forearm deep venous catecholamine concentration, and arterialized venous catecholamine concentration were obtained immediately prior to and following the CPT in each trial. CPT resulted in a significant increase in forearm venous plasma norepinephrine concentration in all trials (P = 0.007), but no change in arterialized plasma norepinephrine (P = 0.32). CPT did not change forearm venous plasma epinephrine (P = 0.596) or arterialized plasma epinephrine concentration (P = 0.15). As assessed by the %reduction in forearm vascular conductance (FVC) the CPT evoked a robust vasoconstriction at rest that was severely blunted in exercise (R = −39.9 ± 4.6% vs. Ex = 5.5 ± 7.4%, P < 0.001). This blunting of vasoconstriction persisted at PEearly (-12.3 ± 10.1%, P = 0.02) and PElate (-18.1 ± 8.2%, P = 0.03) post-exercise. In conclusion, functional sympatholysis remains evident in human skeletal muscle as much as 10 min after the end of a bout of forearm exercise. Persistence of functional sympatholysis may have important implications for blood pressure regulation in the face of a challenge to blood pressure following exercise.

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“…First experiment: The longitudinal (long-axis) view of the right common carotid arteries of 8 (n = 8) healthy subjects was scanned, at 2500 FPS, during 3s to include 4 cardiac cycles before and just after a cold pressor test. This test consists in immersing the right hand in cold water (4-10 °C) during 3 min and has for effect to increase heart reactivity (blood pressure, heart rate) and the PWV [24], [25]. Thanks to that we will be able to see if the WSPR can be seen as stiffness wall marker by performing a relative difference between its maximum amplitude obtained before and after the cold pressor test.…”

Section: A Data Acquisitionmentioning

confidence: 99%

Estimation of arterial wall motion using ultrafast imaging and transverse oscillations: in vivo study

Salles

Long

Petrusca

et al. 2016

2016 IEEE International Ultrasonics Symposium (IUS)

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International audienceEarly detection of cardiovascular diseases can be done by assessing the dynamic properties of arteries. In this study, two phenomena related to the carotid wall motion are presented. The 2D motion estimation method employs (i) ultrafast imaging which became a world-wide use modality, (ii) transverse oscillations technics which allow improving the motion estimation in transverse direction i.e. perpendicular to the beam, and (iii) a 2D phase shift estimator. First, using only the radial acceleration wall, the Wall Spatial Periodic Ripples (WSPR) is studied under a cold pressor test. The results show that the WSPR mean maximum amplitude decreased of 22.9% at the systolic wave and 33.2% at the dicrotic notch. So, the WSPR is a possible artery wall rigidity marker. Then, using a very high frame rate imaging, the longitudinal carotid wall motion of one healthy subject is studied. This second experimentation permits to estimate the propagation of a longitudinal motion on an in vivo carotid. Its mean velocity was evaluated at 16.1 m.s-1, which given a ratio of 3 between with the estimated PWV

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Increased cardiovascular reactivity to the cold pressor test is not associated with increased reactivity to isometric handgrip exercise

Cited by 17 publications

References 29 publications

Carotid haemodynamics during sympathetic nervous system stimulation via handgrip and cold pressor testing in young healthy subjects: A feasibility study

Carotid haemodynamics during sympathetic nervous system stimulation via handgrip and cold pressor testing in young healthy subjects: A feasibility study

Persistence of functional sympatholysis post-exercise in human skeletal muscle

Estimation of arterial wall motion using ultrafast imaging and transverse oscillations: in vivo study

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