Increased capsaicin-induced secondary hyperalgesia as a marker of abnormal sensory activity in patients with fibromyalgia

Increased Capsaicin-induced Secondary Hyperalgesia in Patients With Multiple Chemical Sensitivity

“…Central sensitization measured as an increased capsaicin-induced area of secondary hyperalgesia has also been found in other diseases including rheumatoid arthritis, and FM. 10,19 However, in this study area of secondary hyperalgesia was unaffected by the presence of comorbidity of FM, CFS, and chronic pain. Thus, this reflects a common dysfunction in their central processing of pain stimuli.…”

“…[16][17][18] Another indicator for sensitization is temporal summation, increased response to repeated stimulation as this is also facilitated in patients with chronic pain such FM, 8 and temporomandibular joint disease. 19 In addition, the neurogenic inflammation (flare) generated by capsaicin injection has been found to be enhanced in FM 9 and rheumatoid arthritis. 10 Although MCS recently was suggested to be part of the above mentioned central sensitivity syndromes (CSS) pain processing has never been investigated in MCS patients.…”

Altered Central Sensitization and Pain Modulation in the CNS in Chronic Joint Pain

“…A similar increased hyperalgesic reaction is found in patients with rheumatoid arthritis when they are provoked by a capsaicin challenge [104], which is also found in fibromyalgia [105]. Many studies have observed that patients with chronic musculoskeletal pain show widespread deep-tissue hyperalgesia and develop widespread pain.…”

Gender Differences in Pain and Secondary Hyperalgesia After Heat/Capsaicin Sensitization in Healthy Volunteers

“…3 We have previously demonstrated that central sensitization might play a critical role in maintaining pain and allodynia in postherpetic neuralgia. 21 It has been shown that patients with fibromyalgia and rheumatoid arthritis develop larger areas of secondary hyperalgesia than normal volunteers after application of topical capsaicin 18,19 and that patients with fibromyalgia and temporomandibular disorder have enhanced temporal summation to thermal stimulation. 16,34 On the basis of these findings and the finding that experimentally induced temporal summation of pain evoked by thermal 9 and mechanical stimuli 30,31 is enhanced in women, it was suggested *Adjustment: An adjusted analysis was performed to account for differences in forearm size between genders.…”