Increased capillary vascularity in the femur of aged rats by exercise training

Viboolvorakul, Sheepsumon; Niimi, Hideyuki; Wongeakin, Natchaya; Eksakulkla, Sukanya; Patumraj, Suthiluk

doi:10.1016/j.mvr.2009.07.003

Cited by 31 publications

(34 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition to medications, alternative interventions often prescribed to DM patients, such as exercise/physical activity, may be indirectly useful since they are expected to mitigate microangiopathy in bone by increasing neo vascularization and blood flow. In vivo investigation in swimming rats showed higher bone capillary vascularity compared with sedentary controls [69] . Such higher vas culogenesis following exercise has been postulated to result from an increase in circulating EPCs [70,71] .…”

Section: Dm-induced Osteoporosismentioning

confidence: 98%

Osteoporosis in diabetes mellitus: Possible cellular and molecular mechanisms

Wongdee

Charoenphandhu²

2011

WJD

170

118

View full text Add to dashboard Cite

Osteoporosis, a global age-related health problem in both male and female elderly, insidiously deteriorates the microstructure of bone, particularly at trabecular sites, such as vertebrae, ribs and hips, culminating in fragility fractures, pain and disability. Although osteoporosis is normally associated with senescence and estrogen deficiency, diabetes mellitus (DM), especially type 1 DM, also contributes to and/or aggravates bone loss in osteoporotic patients. This topic highlight article focuses on DM-induced osteoporosis and DM/ osteoporosis comorbidity, covering alterations in bone metabolism as well as factors regulating bone growth under diabetic conditions including, insulin, insulin-like growth factor-1 and angiogenesis. Cellular and molecular mechanisms of DM-related bone loss are also discussed. This information provides a foundation for the better understanding of diabetic complications and for development of early screening and prevention of osteoporosis in diabetic patients.

show abstract

Section: Dm-induced Osteoporosismentioning

confidence: 98%

Osteoporosis in diabetes mellitus: Possible cellular and molecular mechanisms

Wongdee

Charoenphandhu²

2011

WJD

170

118

View full text Add to dashboard Cite

show abstract

“…Interestingly, when bone angiogenesis was inhibited with administration of an anti-vascular endothelial growth factor antibody in conjunction with treadmill exercise training, bone mineral density, bone volume and blood vessel number were comparable to the sedentary group (Yao et al 2004); i.e., the inhibition of the vascular adaptation to exercise prohibited the adaptation to bone, even in the face of mechanical perturbation. Similarly, bone capillarity in aged, exercise-trained rats was augmented following 8 weeks of swimming in comparison to aged control animals (Viboolvorakul et al 2009). The interesting aspect of this study is that the non-weight bearing activity of swimming minimized the mechanical loads placed upon the skeleton in comparison to weight-bearing exercise such as treadmill running.…”

Section: Introductionmentioning

confidence: 99%

“…While swimming, the skeleton would have only experienced the mechanical loads associated with muscle contraction; however, alterations in bone vascular density were still observed. Unfortunately, no parameters were reported for potential alterations in bone (Viboolvorakul et al 2009). …”

Section: Introductionmentioning

confidence: 99%

Mechanical, hormonal and metabolic influences on blood vessels, blood flow and bone

Prisby

2017

Journal of Endocrinology

View full text Add to dashboard Cite

Bone tissue is highly vascularized due to the various roles bone blood vessels play in bone and bone marrow function. For example, the vascular system is critical for bone development, maintenance and repair, and provides O2, nutrients, waste elimination, systemic hormones, and precursor cells for bone remodeling. Further, bone blood vessels serve as egress and ingress routes for blood and immune cells to and from the bone marrow. It is becoming increasingly clear that the vascular and skeletal systems are intimately linked in metabolic regulation and physiological and pathological processes. This review examines how agents such as mechanical loading, parathyroid hormone, estrogen, vitamin D and calcitonin, all considered anabolic for bone, have tremendous impacts on the bone vasculature. In fact, these agents influence bone blood vessels prior to impacting bone. Further, data reveal strong associations between vasodilator capacity of bone blood vessels and trabecular bone volume, and poor associations between estrogen status and uterine mass and trabecular bone volume. Additionally, this review highlights the importance of the bone microcirculation, particularly the vascular endothelium and NO-mediated signaling, in the regulation of bone blood flow, bone interstitial fluid flow and pressure, and the paracrine signaling of bone cells. Finally, the vascular endothelium as a mediator of bone health and disease is considered.

show abstract

“…By using Image Pro II Software, the total number of pixels that were located within a capillary network was determined (Figure 2) and divided by 100 × 100-pixel-ROI area. The % CV that corresponded to capillary density [24–26] was defined as follows:…”

Section: Methodsmentioning

confidence: 99%

Acanthus ebracteatusVahl. Ethanol Extract Enhancement of the Efficacy of the Collagen Scaffold in Wound Closure: A Study in a Full-Thickness-Wound Mouse Model

Somchaichana

Bunaprasert²,

Patumraj³

2012

Journal of Biomedicine and Biotechnology

Self Cite

View full text Add to dashboard Cite

Acanthus ebracteatus Vahl. is a Thai herb that is effective in wound healing. We sought to quantitatively determine whether or not the combined application of Acanthus ebracteatus Vahl. and a collagen scaffold will increase wound closure and angiogenesis. Balb/c mice (body weight: 22–25 g) were anesthetized with sodium thiopental. The dorsal skin incision measuring 1.5 × 1.5 cm was made and then deepened using scissors to produce a full-thickness incision down to the level of the panniculus carnosus. The size of the wound was approximately 10% of the total body surface area. The collagen sheet was implanted onto the wound. Animals were divided into 4 major groups as follows: wound with normal saline (W-NSS), wound treated with 0.3 g/kg BW of Acanthus ebracteatus Vahl. extract (W-AE (0.3 g/kg.bw)), wound implanted with collagen scaffold (W-Coll), and wound implanted with collagen scaffold and treated with 0.3 g/kg BW of Acanthus ebracteatus Vahl. (W-Coll-AE combination). On day 14, the W-Coll-AE group showed decreased wound areas and increased capillary vascularity (CV) when compared to the other 3 groups, W-NSS, W-AE0.3, and W-Coll. In the present study, the combination of AE0.3 with collagen showed the best effect on skin angiogenesis and promoted wound closure with less neutrophil infiltration.

show abstract

Increased capillary vascularity in the femur of aged rats by exercise training

Cited by 31 publications

References 19 publications

Osteoporosis in diabetes mellitus: Possible cellular and molecular mechanisms

Osteoporosis in diabetes mellitus: Possible cellular and molecular mechanisms

Mechanical, hormonal and metabolic influences on blood vessels, blood flow and bone

Acanthus ebracteatusVahl. Ethanol Extract Enhancement of the Efficacy of the Collagen Scaffold in Wound Closure: A Study in a Full-Thickness-Wound Mouse Model

Contact Info

Product

Resources

About