Increased capillary filtration of albumin in diabetic patients—relation with gender, hypertension, microangiopathy, and neuropathy

Valensi, P.; Béhar, A.; Attalah, M.; Cohen-Boulakia, F; Pariès, J.; Attali, J. R.

doi:10.1016/s0026-0495(98)90231-1

Cited by 23 publications

(14 citation statements)

References 23 publications

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“…It is unsure if the target of anthocyanins is only AMPK or adiponectin. During the onsets of diabetic microangiopathic, microvascular permeability and the number of leucocytes sticking to the venular endothelium are increased [123]. In db/db mice, cyanidin-3-glucoside (2 g/kg diet) increases adiponectin secretion from adipose tissue, thus it protects the mice against diabetes-related endothelial dysfunction [89].…”

Section: Nutraceutical and Pharmaceutical Effects Of Anthocyaninsmentioning

confidence: 99%

Anthocyanidins and anthocyanins: colored pigments as food, pharmaceutical ingredients, and the potential health benefits

Khoo

Azlan

Tang

et al. 2017

Food & Nutrition Research

1,991

1,327

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Anthocyanins are colored water-soluble pigments belonging to the phenolic group. The pigments are in glycosylated forms. Anthocyanins responsible for the colors, red, purple, and blue, are in fruits and vegetables. Berries, currants, grapes, and some tropical fruits have high anthocyanins content. Red to purplish blue-colored leafy vegetables, grains, roots, and tubers are the edible vegetables that contain a high level of anthocyanins. Among the anthocyanin pigments, cyanidin-3-glucoside is the major anthocyanin found in most of the plants. The colored anthocyanin pigments have been traditionally used as a natural food colorant. The color and stability of these pigments are influenced by pH, light, temperature, and structure. In acidic condition, anthocyanins appear as red but turn blue when the pH increases. Chromatography has been largely applied in extraction, separation, and quantification of anthocyanins. Besides the use of anthocyanidins and anthocyanins as natural dyes, these colored pigments are potential pharmaceutical ingredients that give various beneficial health effects. Scientific studies, such as cell culture studies, animal models, and human clinical trials, show that anthocyanidins and anthocyanins possess antioxidative and antimicrobial activities, improve visual and neurological health, and protect against various non-communicable diseases. These studies confer the health effects of anthocyanidins and anthocyanins, which are due to their potent antioxidant properties. Different mechanisms and pathways are involved in the protective effects, including free-radical scavenging pathway, cyclooxygenase pathway, mitogen-activated protein kinase pathway, and inflammatory cytokines signaling. Therefore, this review focuses on the role of anthocyanidins and anthocyanins as natural food colorants and their nutraceutical properties for health. Abbreviations: CVD: Cardiovascular disease VEGF: Vascular endothelial growth factor

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Section: Nutraceutical and Pharmaceutical Effects Of Anthocyaninsmentioning

confidence: 99%

Anthocyanidins and anthocyanins: colored pigments as food, pharmaceutical ingredients, and the potential health benefits

Khoo

Azlan

Tang

et al. 2017

Food & Nutrition Research

1,991

1,327

View full text Add to dashboard Cite

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“…[19][20][21] Microangiopathy also affects endothelial function with increased capillary permeability to large proteins and molecules in diabetic patients, a feature that can be seen by the transcapillary escape rate of radiolabelled albumin. 22,23 Removal and drainage of interstitial albumin appears to be delayed in diabetic patients, suggesting a defect in lymphatic function due to overflow saturation of the lymph pumps. 22 Hence, although diabetes does not cause direct damage to the lymphatic vessels, the processes of normal interstitial fluid homeostasis are affected with the increase in transport capacity that overwhelms the drainage system.…”

Section: Diabetic Microangiopathy and Lymphedemamentioning

confidence: 99%

“…22,23 Removal and drainage of interstitial albumin appears to be delayed in diabetic patients, suggesting a defect in lymphatic function due to overflow saturation of the lymph pumps. 22 Hence, although diabetes does not cause direct damage to the lymphatic vessels, the processes of normal interstitial fluid homeostasis are affected with the increase in transport capacity that overwhelms the drainage system. This has been demonstrated by the improvement of edema and notable reduction in local capillary filtration with drugs acting on capillary permeability such as O-(beta-hydroxyethyl)-rutosides and Pycnogenol in subjects with diabetic microangiopathy.…”

Section: Diabetic Microangiopathy and Lymphedemamentioning

confidence: 99%

“…27 The functional subunit in lymphatic vessels is the lymphangion, wall of which consists of smooth muscle cells that propel lymph in a peristaltic manner, contraction of which is under neural control. 22 Analogous to the blood vessels, the peripheral lymphatic vessels and smooth muscle subunits are under autonomic control. Diabetic neuropathy can lead to lymphatic pump failure, impairing interstitial fluid uptake from the distal part of the limb and disrupting lymphatic fluid transport along the lymphatic vessels.…”

Section: Diabetic Neuropathy and Lymphedemamentioning

confidence: 99%

“…Diabetic neuropathy can lead to lymphatic pump failure, impairing interstitial fluid uptake from the distal part of the limb and disrupting lymphatic fluid transport along the lymphatic vessels. 22 The disorder in absorption and transport of lymphatic fluid is analogous to direct neural injury with sympathetic denervation interruption seen in trauma where management by complex physical decongestion therapy with manual lymphatic drainage (MLD) results in clinical improvement. 28 …”

Section: Diabetic Neuropathy and Lymphedemamentioning

confidence: 99%

See 2 more Smart Citations

Diabetic foot ulcers in conjunction with lower limb lymphedema: pathophysiology and treatment procedures

Kanapathy¹,

Portou²,

Tsui³

et al. 2015

CWCMR

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Diabetic foot ulcers (DFUs) are complex, chronic, and progressive wounds, and have a significant impact on morbidity, mortality, and quality of life. A particular aspect of DFU that has not been reviewed extensively thus far is its management in conjunction with peripheral limb edema. Peripheral limb edema is a feature of diabetes that has been identified as a significant risk factor for amputation in patients with DFU. Three major etiological factors in development of lymphedema with concurrent DFU are diabetic microangiopathy, failure of autonomic regulation, and recurrent infection. This review outlines the pathophysiology of lymphedema formation in patients with DFU and highlights the cellular and immune components of impaired wound healing in lymphedematous DFU. We then discuss the principles of management of DFU in conjunction with lymphedema.

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Lymphatic system changes in diabetes mellitus: role of insulin and hyperglycemia

Moriguchi

Sannomiya

Lara

et al. 2005

Diabetes Metab. Res. Rev.

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Increased capillary filtration of albumin in diabetic patients—relation with gender, hypertension, microangiopathy, and neuropathy

Cited by 23 publications

References 23 publications

Anthocyanidins and anthocyanins: colored pigments as food, pharmaceutical ingredients, and the potential health benefits

Anthocyanidins and anthocyanins: colored pigments as food, pharmaceutical ingredients, and the potential health benefits

Diabetic foot ulcers in conjunction with lower limb lymphedema: pathophysiology and treatment procedures

Lymphatic system changes in diabetes mellitus: role of insulin and hyperglycemia

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