2001
DOI: 10.1096/fj.00-0813fje
|View full text |Cite
|
Sign up to set email alerts
|

Increased cAMP levels and protein kinase (PKA) type I activation in CD4+ T cells and B cells contribute to the retrovirus‐induced immunodeficiency of mice (MAIDS). A useful in vivo model for drug testing in PKA type I‐ induced immunodeficiency

Abstract: Murine AIDS (MAIDS) is characterized by a lymphoproliferative disease and a profound anergy, which involves mostly CD4 + T cells. To better define the mechanisms responsible for anergy, we measured cAMP concentrations in the different lymphocyte subsets of the infected mice. CD4 + T cells and B cells displayed a dramatic 10-to 30-fold increase of cAMP. cAMP was also significantly increased in CD8 + T cells, although to a far lesser extent. The unusual CD4 + CD90 -T cells, typical of MAIDS, were characterized b… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1

Citation Types

0
24
0

Year Published

2003
2003
2011
2011

Publication Types

Select...
5
1

Relationship

2
4

Authors

Journals

citations
Cited by 20 publications
(24 citation statements)
references
References 68 publications
0
24
0
Order By: Relevance
“…Hyperactivation of the cAMP-type I PKA pathway has been implicated in the T cell dysfunction associated with HIV infection (18) and a subset of common variable immunodeficiency (58), and is also involved in the T cell dysfunction in MAIDS (16,17).…”
Section: Discussionmentioning
confidence: 99%
See 4 more Smart Citations
“…Hyperactivation of the cAMP-type I PKA pathway has been implicated in the T cell dysfunction associated with HIV infection (18) and a subset of common variable immunodeficiency (58), and is also involved in the T cell dysfunction in MAIDS (16,17).…”
Section: Discussionmentioning
confidence: 99%
“…The ability of T cells to proliferate in response to CD3 stimulation declines progressively during the course of MAIDS, partially because of high intracellular levels of cAMP and the resulting type I PKA-mediated inhibition of T cell activation (16,17). In this study, lymph node cells from LP-BM5-infected RIADtransgenic mice and sex-matched wild-type littermates were stimulated with soluble CD3 Ab and/or IL-2 for 72 h and proliferation assessed as [ 3 H]thymidine incorporation.…”
Section: Resistance To Disease Progression In Lp-bm5-infected Riad-trmentioning
confidence: 99%
See 3 more Smart Citations