Increased caffeine consumption is associated with reduced hepatic fibrosis

Modi, Apurva A.; Feld, Jordan J.; Park, Yoon; Kleiner, David E.; Everhart, James E.; Liang, T. Jake; Hoofnagle, Jay H.

doi:10.1002/hep.23279

Cited by 257 publications

(208 citation statements)

References 26 publications

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“…In various studies including a large prospective study, patients with HCV-related liver disease with a regular coffee consumption show a lower rate of disease progression such as hepatic fibrosis [131][132][133] and HCC [134][135][136][137][138] . Recently, it was also reported that more than 3 cups per day coffee drinkers are three times more likely to have a virological response to peginterferon plus ribavirin treatment than non-drinkers [139] .…”

Section: Coffee Consumptionmentioning

confidence: 99%

Insulin resistance and chronic liver disease

Kawaguchi

Taniguchi²,

Itou³

et al. 2011

WJH

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Increased insulin resistance is frequently associated with chronic liver disease and is a pathophysiological feature of hepatogenous diabetes. Distinctive factors including hepatic parenchymal cell damage, portalsystemic shunting and hepatitis C virus are responsible for the development of hepatogenous insulin resistance/ diabetes. Although it remains unclear whether insulin secretion from pancreatic beta cells is impaired as it is in type 2 diabetes, retinopathic and cardiovascular risk is low and major causes of death in cirrhotic patients with diabetes are liver failure, hepatocellular carcinoma and gastrointestinal hemorrhage. Hemoglobin A1c is an inaccurate marker for the assessment and management of hepatogenous diabetes. Moreover, exogenous insulin or sulfonylureas may be harmful because these agents may promote hepatocarcinogenesis. Thus, pathogenesis, cause of death, assessment and therapeutic strategy for hepatogenous insulin resistance/diabetes differ from those for lifestyle-related type 2 diabetes. In this article, we review features of insulin resistance in relationship to chronic liver disease. We also discuss the impact of anti-diabetic agents on interferon treatment and hepatocarcinogenesis.

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Section: Coffee Consumptionmentioning

confidence: 99%

Insulin resistance and chronic liver disease

Kawaguchi

Taniguchi²,

Itou³

et al. 2011

WJH

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“…Work of Ruhl and Everhart [17] has reported that the relationship between caffeine intake and reduced serum ALT levels was of prime importance than that for coffee. Sharp and Benowitz [18] have suggested that caffeine administration and serum level of caffeine were related to decreased levels of GGT however, studies performed in animals have provided data that caffeine has been effective in inhibiting chemical induced carcinogenesis [19]. Liver enzymes level may be affected by coffee components.…”

Section: Role Of Caffeinementioning

confidence: 99%

“…Coffee consumption has also suggested to be related to lower severeness of liver problems and lower speed of liver disease progression [17,52,53]. Epidemiological data obtained from studies have strongly suggested that consumption of coffee is defensive against hepatocellular carcinoma (HCC) as well as chronic liver disease (CLD) [18,[54][55][56][57][58][59]. There are hundreds of compounds in coffee, namely caffeine, diterpenes, potassium, niacin,magnesium, antioxidants, chlorogenic acids and tocopherols [60].…”

Section: The Mechanism Of Coffee's Hepatoprotective Effectmentioning

confidence: 99%

“…However, the outcomes provided by these studies do not explain this elucidation [44,47]. The histologically beneficial effect of coffee was first represented by Modi et al He analyzed the relationship between intake of caffeine on daily basis and severeness of hepatic fibrosis amongst the patients with chronic liver diseases [18]. The authors suggest that daily intake of two or more cups of coffee were related to reduce rates of hepatic fibrosis (Figure 3).…”

Section: The Mechanism Of Coffee's Hepatoprotective Effectmentioning

confidence: 99%

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Multiple Beneficial effects Associated with Coffee Consumption on Human Liver

Saleem¹,

Latif²

2017

J Hepatol Gastroint Dis

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Coffee is widely consumed beverage in the world. Incidence of chronic liver disease decreases with intake of coffee.The main objective of this study is to elucidate the hepatoprotective as well as chemo protective effect of coffee consumption in relation to previous published data. Prospective cohort studies based on relationship between coffee intake and ultimate effects on liver cancer have drawn various conclusions. Coffee's beneficial effects in various disease states have been demonstrated in variety of studies. Studies have provided data regarding effects of coffee in hot as well as in cold state. Level of blood cholesterol, following filtration, is affected by the coffee components. Among the components of coffee, caffeine played the significant role in reducing the level of ALT in coffee consumers as compared with non-coffee consumers. Coffee intake is associated with cardiovascular events and hypertension risks. However, intake of coffee has been found to be inversely related to the level of serum enzymes like gamma-glutamyltransferase, and alanine aminotransferase when studies relating to coffee effect on liver were performed in different countries. Moreover, the data based on epidemiological analysis, clearly suggested that liver cirrhosis had inverse relationship with coffee consumption; however, the results obtained were not sufficient to demonstrate that coffee may have hepatoprotective effect in liver injury. There is emerging evidence revealing that consumption of coffee has been associated with reduction of risks of various types of cancers. The emerging data on coffee consumption has revealed that it has beneficial effects in colorectal, pancreatic, and pharyngeal as well as in liver cancer. A systematic review was performed regarding association of coffee consumption and effect of coffee intake on liver diseases like hepatocellular carcinoma (HCC), viral hepatitis, cirrhosis and nonalcoholic fatty liver disease (NAFLD). Coffee consumption, in dose dependent manner, was found to improve the level of serum gamma-glutamyltransferase, alanine aminotransferase and aspartate aminotransferase in individuals which were found to be at risk of liver diseases. Anticancer effect of coffee on liver is achieved by induction as well as inhibition of specific enzymes. The patients with history of chronic liver disease who consume coffee, were reported to be at a reduced risk of liver to be cirrhotic, and a decreased mortality rate was observed in cirrhosis patients, as well as a decreased rate of development of Hepatocellular carcinoma was observed. In individuals with history of chronic hepatitis C, coffee intake was found to be associated with enhanced virologic reaction to antiviral drug therapy. Furthermore, coffee intake was reported to be inversely associated with the severeness of steatohepatitis in individuals with non-alcoholic fatty liver disorder. Therefore, in patients with chronic liver disease, coffee consumption on daily basis should be persuaded.

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“…In the two last study conducted by The National Health and Nutrition Examination Survey (NHANES) I and III, its was reported that high coffee consumption (more than two cups per day) were strongly associated with lower risk in increase transaminase enzyme and chronic liver disease. 2 Chronic liver disease, such as cirrhosis and hepatocellular carcinoma, were a highly morbidity and mortality disease. Patient with those end stage liver disease have a higher risk of liver failure, even 80% among them could lead to hepatocellular carcinoma.…”

Section: Introductionmentioning

confidence: 99%