Increased C-reactive protein level after coronary stent implantation in patients with stable coronary artery disease

Almagor, Miriam; Keren, Andre; Banai, Shmuel

doi:10.1067/mhj.2003.16

Cited by 76 publications

(52 citation statements)

References 38 publications

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“…Almagor et al (32) showed an inflammatory response with high CRP levels after stent implantation to patients who have stable angina pectoris. Xu et al (33) also found that the CRP levels at both pre-percutaneous coronary intervention and follow-up were significantly correlated with stent restenosis.…”

Section: Discussionmentioning

confidence: 99%

Could plasma asymmetric dimethylarginine level be a novel predictor beyond the classic predictors of stent restenosis?

Bal¹,

Yı́ldı́rı́r²,

Aydınalp³

et al. 2014

Anadolu Kardiyol Derg

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Objective: The aim of this study was to investigate the factors associated with coronary stent restenosis and if there is an association between plasma asymmetric dimethylarginine (ADMA) levels and stent restenosis. Methods: Ninety-one patients, who had a history of coronary bare metal stent implantation due to any cause in the last one year period, were admitted to this observational cross-sectional study. Coronary angiography was performed to all patients and quantitative angiography was used to determine the presence of stent restenosis. Laboratory parameters and angiographic features that contribute to stent restenosis were evaluated. Plasma ADMA levels were measured by using high performance liquid chromatography. Logistic regression analysis was used to determine the independent factors of stent restenosis. Results: Angiographic restenosis was found in 35 patients (38.5%). Stent diameter (p=0.038) and left ventricular ejection fraction (p=0.023) were lower and stent implantation history due to acute coronary syndrome (p=0.029), plasma ADMA level (5.0±1.8x10 -4 mmol/L vs. 3.9±1.0x10 -4 mmol/L, p=0.001), C-reactive protein concentration (p=0.016), white blood cell count (p=0.044) and stent length (p=0.005) were higher in patients with restenosis. Plasma ADMA level (β=0.536; OR: 1.710; CI: 1.022-2.861; p=0.041), C-reactive protein concentration (β=0.062; OR: 1.064; CI: 1.003-1.129; p=0.041), stent diameter (β=-3.047; OR: 0.048; CI: 0.007-0.313; p=0.002) and length (β=0.165; OR: 1.179; CI: 1.036-1.343; p=0.013) were found to be the independent predictors of stent restenosis in logistic regression analysis. Conclusion: We conclude that plasma ADMA levels may be used as a novel marker for stent restenosis beyond the classic stent restenosis markers. (Anadolu Kardiyol Derg 2014; 14: 491-7)

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Section: Discussionmentioning

confidence: 99%

Could plasma asymmetric dimethylarginine level be a novel predictor beyond the classic predictors of stent restenosis?

Bal¹,

Yı́ldı́rı́r²,

Aydınalp³

et al. 2014

Anadolu Kardiyol Derg

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“…It has been clearly demonstrated that the CRP level increases in patients undergoing PCI (1,2,6). Evidence also shows that inflammation indicated by the post-procedural increase in CRP is a predictor of restenosis in patients after coronary stenting (7).…”

Section: Introductionmentioning

confidence: 99%

Pravastatin therapy fails to suppress post-PCI inflammatory response measured by serum neopterin and CRP levels

Bozbaş¹,

Mermer²,

Yildirir³

et al. 2011

Anadolu Kardiyol Derg

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ÖZETAmaç: Perkütan koroner girişim (PKG) sonrası hem lokal, hem de sistemik bir enflamatuvar yanıt meydana gelmektedir. Statinler lipit düşürücü etkilerinin yanında iyi tanımlanmış antienflamatuvar etkilere de sahiptirler. Bu çalışmada pravastatin tedavisinin elektif PKG yapılan hastalarda işlem sonrası serum C-reaktif protein (CRP) ve neopterin düzeyine olan etkisinin değerlendirilmesi amaçlanmıştır. Yöntemler: Bu prospektif, randomize çalışmaya elektif PKG planlanan 93 hasta dahil edildi. Grup 1'e (n=30) pravastatin 10mg/gün, Grup 2'ye (n=29) 40 mg/gün başlandı; Grup 3 (n=34) kontrol grubu alındı ve bu gruba lipit düşürücü tedavi verilmedi. Hastalardan işlem öncesi, işlemden sonra kan örnekleri alınarak serum CRP ve neopterin düzeyleri çalışıldı. Devamlı değişkenlerin gruplar arası karşılaştırılması ANOVA ve KruskalWallis testi ile yapıldı. Devamlı olmayan değişkenler ise Ki-kare testi ile değerlendirildi. Bulgular: Hastaların demografik özellikleri ve PKG ile ilişkili verileri (işlem yapılan damar sayısı, balon şişirme sayısı ve süresi) gruplar arasında benzer idi (p>0.05). Serum CRP ve neopterin düzeylerinde işlemden sonra anlamlı artış saptandı (p<0.001). İşlem öncesi ve sonrası ortalama serum neopterin düzeyleri gruplar arasında şu şekilde idi: Grup 1: 13.3±5.9 ve 22.8±15.4 nmol/L; Grup 2: 16.9±10.2 ve 22.0±14.9 nmol/L; kontrol grubu: 15.2±11.9 ve 18.8±11.5nmol/L. İşlem öncesi başlanan pravastatin tedavisinin bu enflamasyon parametrelerine anlamlı bir etkisi saptanmadı (F=0.5, p=0.6). Sonuç: Perkütan koroner girişim (PKG) belirgin bir enflamatuvar yanıta yol açmaktadır. İşlem öncesi 2 farklı dozda başlanan pravastatin tedavisinin kısa süreli izlemde bu inflamatuvar yanıtı baskılamada yetersiz kaldığı görülmüştür. Bu konunun daha iyi aydınlatılabilmesi için ileri çalış-malara ihtiyaç vardır. (Anadolu Kardiyol Derg 2011; 11: 207-12) Anahtar kelimeler: Statin, C-reaktif protein, neopterin, perkütan koroner girişim ABSTRACT Objective: Percutaneous coronary intervention (PCI) is known to induce both local and systemic inflammatory states. In addition to lowering lipid levels, statins exert well-proven anti-inflammatory effects. We investigated the effects of pravastatin on serum C-reactive protein (CRP) and neopterin levels in the short term after elective PCI. Methods: In this randomized prospective study, 93 patients undergoing elective PCI were enrolled. Group 1 (n=30) received pravastatin at a dose of 10 mg/day, Group 2 (n=29) was given 40 mg/day, and Group 3 (n=34) served as the control group and received no lipid-lowering drugs. Blood samples were drawn before and after PCI to measure serum CRP and neopterin levels. Differences among the groups for continuous variables were evaluated by the ANOVA and the Kruskal-Wallis test as appropriate. The Chi-square test was used for comparison of categorical variables. Results: Demographic features and the characteristics of the PCI, including the number of vessels and lesions and the duration and number of inflations, did not differ among groups (p>0.05). Serum CRP...

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“…ALMAGOR et al [1] demonstrated that levels of reactive protein C in patients after coronary stent implantation were persistently high over the medium term, constituting a continuous systemic inflammatory response.…”

Section: Coronary Stenting and Inflammationmentioning

confidence: 99%

“…However, recent evidence has demonstrated that the coronary stent may induce the appearance of Systemic Inflammatory Response Syndrome (SIRS) [1,2], where restenosis after stent implantation constitutes the earliest manifestation of an inflammatory reaction. SIRS, the consequent endothelial dysfunction and ischemia are events that follow and are little understood.…”

mentioning

confidence: 99%

Coronary stenting and inflammation

Gomes¹,

Buffolo²

2003

Rev Bras Cir Cardiovasc

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Increased C-reactive protein level after coronary stent implantation in patients with stable coronary artery disease

Cited by 76 publications

References 38 publications

Could plasma asymmetric dimethylarginine level be a novel predictor beyond the classic predictors of stent restenosis?

Could plasma asymmetric dimethylarginine level be a novel predictor beyond the classic predictors of stent restenosis?

Pravastatin therapy fails to suppress post-PCI inflammatory response measured by serum neopterin and CRP levels

Coronary stenting and inflammation

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