Increased C reactive protein in response to acute stress in patients with rheumatoid arthritis

Zanten, Jet J.C.S. Veldhuijzen van; Ring, Christopher; Carroll, Douglas; Kitas, George D.

doi:10.1136/ard.2004.032151

Cited by 55 publications

(68 citation statements)

References 34 publications

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“…Thus, the experimental manipulations induced increase in IL-6 values which were similar to those at risk for MI. Furthermore, the mental stress task used in the present study elicited a physiological response similar to previous studies (Paine et al, 2013a;Veldhuijzen van Zanten et al, 2005. Heart rate, blood pressure and total numbers of white blood cells increased in all conditions during the mental stress task (figure 2).…”

Section: Discussionsupporting

confidence: 83%

“…Previous studies have suggested a role for baseline inflammation on physiological responses to mental stress (Roupe van der Voort et al, 2000;Shah et al, 2006;Veldhuijzen van Zanten et al, 2005). In the current study, we used two established experimental paradigms to induce inflammation in healthy participants to specifically assess the influence of inflammation on the oxidative stress responses to mental stress.…”

Section: Discussionmentioning

confidence: 97%

“…A 16-minute version of the paced auditory serial addition task (PASAT) was used to induce acute mental stress in all participants (Veldhuijzen van Zanten et al, 2005). A series of single digit numbers were dictated to participants via a CD player.…”

Section: Mental Stress Taskmentioning

confidence: 99%

“…For example, the well documented ROS burst from inflammatory neutrophils (Babior et al, 1973) could follow from a mental stress-induced inflammatory response Veldhuijzen van Zanten et al, 2005). Furthermore, altered blood flow and shear stress patterns (i.e.…”

Section: Introductionmentioning

confidence: 99%

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Underlying inflammation has no impact on the oxidative stress response to acute mental stress

Wadley¹,

Zanten²,

Paine³

et al. 2014

Brain, Behavior, and Immunity

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 97%

Section: Mental Stress Taskmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Underlying inflammation has no impact on the oxidative stress response to acute mental stress

Wadley¹,

Zanten²,

Paine³

et al. 2014

Brain, Behavior, and Immunity

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“…Recently, the impact of stress and hormones on the regulation of CRP production has been discussed [19,20].…”

mentioning

confidence: 99%

Pathogenic implications for autoantibodies against C-reactive protein and other acute phase proteins

Sjöwall

Wetterö

2007

Clinica Chimica Acta

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Systemic lupus erythematosus (SLE) is a systemic rheumatic disease characterized clinically by multiorgan involvement and serologically by the occurrence of antinuclear antibodies. SLE patients may present with multiple autoantibodies to cytoplasmic and cell surface antigens as well as to circulating plasma proteins. Another feature of SLE is that serum levels of C-reactive protein (CRP) often remain low despite high disease activity and despite high levels of other acute phase proteins and interleukin-6, i.e. the main CRP inducing cytokine. Apart from its important role as a laboratory marker of inflammation, CRP attracts increasing interest due to its many intriguing biological functions, one of which is a role as an opsonin contributing to the elimination of apoptotic cell debris, e.g. nucleosomes, thereby preventing immunization against autoantigens. Recently, autoantibodies against CRP and other acute phase proteins have been reported in certain rheumatic conditions, including SLE. Although the presence of anti-CRP autoantibodies does not explain the failed CRP response in SLE, antibodies directed against acute phase proteins have several implications of pathogenetic interest. This paper thus highlights the biological and clinical aspects of native and monomeric CRP and anti-CRP, as well as autoantibodies against mannose-binding lectin, serum amyloid A and serum amyloid P component. © 2006 Elsevier B.V. All rights reserved

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Pain sensitivity and pain reactivity in osteoarthritis

Lee

Lü

Bathon

et al. 2011

Arthritis Care & Research

136

116

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Objective In systemic inflammatory diseases such as rheumatoid arthritis, pain and inflammation exhibit reciprocal inter-relationships. However, the nature of the association between pain and inflammation in osteoarthritis (OA) is not clear. We assessed experimental pain sensitivity and compared the inflammatory response to pain in 26 OA patients and 33 age-and sex-matched controls from the general population. Methods Participants underwent psychophysical pain testing to assess pain sensitivity in response to heat, cold and mechanical stimuli. Blood samples were taken at baseline and four time points after testing to determine the effect of acute pain on C-reactive protein (CRP), interleukin 6 (IL-6), interleukin-1beta (IL-1β) and tumor necrosis factor-alpha (TNF-α). Results OA patients had lower pressure pain thresholds (P ≤ 0.003) and higher heat pain ratings (P ≤ 0.04) than controls across multiple body sites. OA patients had higher CRP levels than controls (P = 0.007). CRP levels did not change in response to pain testing. Although not statistically significant, OA patients tended to have higher IL-6 levels than controls (P = 0.12). IL-6 levels increased after pain testing in OA patients and controls (P < 0.0001), but the amount of increase was not different between the two groups. Among OA patients, heightened pain sensitivity was associated with elevated CRP and IL-6 (P ≤ 0.05). Conclusions Compared to controls, OA patients are more sensitive to experimental pain at multiple body sites. IL-6 levels in OA patients and controls exhibited reactivity to acute painful stimuli, increasing at similar rates after psychophysical pain testing.

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Increased C reactive protein in response to acute stress in patients with rheumatoid arthritis

Cited by 55 publications

References 34 publications

Underlying inflammation has no impact on the oxidative stress response to acute mental stress

Underlying inflammation has no impact on the oxidative stress response to acute mental stress

Pathogenic implications for autoantibodies against C-reactive protein and other acute phase proteins

Pain sensitivity and pain reactivity in osteoarthritis

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