Increased BST-2 expression by HBV infection promotes HBV-associated HCC tumorigenesis

Zhang, Jun; Zheng, Baisong; Zhou, Xiaolei; Zheng, Tianhang; Wang, Hong; Wang, Yingchao; Zhang, Wenyan

doi:10.21037/jgo-20-356

Cited by 4 publications

(6 citation statements)

References 48 publications

(57 reference statements)

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Section: Bst2: Roles In Carcinogenesismentioning

confidence: 85%

“…Previous studies have shown that BST2 expression is significantly higher in HCC tissues than that in normal tissues (20,67,68). Similar results were confirmed in HCC cell lines, such as HepG2, Huh7, L02, HepAD38 and Huh7.5 (67,69,70). Xu et al (20) reported that BST2 upregulation is significantly associated with larger tumor size and overall survival, but is not related to sex, age, tumor differentiation, pathological grade and tumor-node-metastasis (TNM) stage, suggesting that BST2 could be an independent unfavorable prognosis factor (Table I).…”

Section: Association With High Bst2 Expressionmentioning

confidence: 98%

“…Xu et al ( 20 ) reported that BST2 upregulation is significantly associated with larger tumor size and overall survival, but is not related to sex, age, tumor differentiation, pathological grade and tumor-node-metastasis (TNM) stage, suggesting that BST2 could be an independent unfavorable prognosis factor ( Table I ). Another study revealed that high BST2 expression is also associated with HBV infection and overall survival ( 67 ). These studies have shown that higher expression of BST2 in patients with HCC is associated with a poorer prognosis.…”

Section: Bst2: Roles In Carcinogenesismentioning

confidence: 99%

“…First, IFNα can induce BST2 expression in HCV-infected or Dengue virus-infected HCC tissues or cell lines ( 69 – 71 ). HBV can also upregulate the expression of the BST2 gene in HCC tissues or cell lines ( 67 ). These studies suggested that BST2 may be an essential factor for the virus-induced tumorigenesis of HCC.…”

Section: Bst2: Roles In Carcinogenesismentioning

confidence: 99%

“…Non-N-glycosylation of BST2 at the N65 site is essential for BST2 function, and can promote the proliferation, migration, invasion and colony-forming ability of HCC cells through activating the NF-κB/ERK pathway. Non-N-glycosylation of BST2 may be a novel factor of BST2 in regulating HCC tumorigenesis ( 67 ). BST2 can also activate EGFR in a lipid raft-dependent manner, not mediated by EGFR ligands.…”

Section: Bst2: Roles In Carcinogenesismentioning

confidence: 99%

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Bone marrow stromal cell antigen 2: Tumor biology, signaling pathway and therapeutic targeting (Review)

Yu,

Bian,

Wang

et al. 2024

Oncol Rep

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Bone marrow stromal cell antigen 2 (BST2) is a type II transmembrane protein that serves critical roles in antiretroviral defense in the innate immune response. In addition, it has been suggested that BST2 is highly expressed in various types of human cancer and high BST2 expression is related to different clinicopathological parameters in cancer. The molecular mechanism underlying BST2 as a potential tumor biomarker in human solid tumors has been reported on; however, to the best of our knowledge, there has been no review published on the molecular mechanism of BST2 in human solid tumors. The present review focuses on human BST2 expression, structure and functions; the molecular mechanisms of BST2 in breast cancer, hepatocellular carcinoma, gastrointestinal tumor and other solid tumors; the therapeutic potential of BST2; and the possibility of BST2 as a potential marker. BST2 is involved in cell membrane integrity and lipid raft formation, which can activate epidermal growth factor receptor signaling pathways, providing a potential mechanistic link between BST2 and tumorigenesis. Notably, BST2 may be considered a universal tumor biomarker and a potential therapeutical target.

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Section: Bst2: Roles In Carcinogenesismentioning

confidence: 85%

Section: Association With High Bst2 Expressionmentioning

confidence: 98%

Section: Bst2: Roles In Carcinogenesismentioning

confidence: 99%

Section: Bst2: Roles In Carcinogenesismentioning

confidence: 99%

Section: Bst2: Roles In Carcinogenesismentioning

confidence: 99%

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Bone marrow stromal cell antigen 2: Tumor biology, signaling pathway and therapeutic targeting (Review)

Yu,

Bian,

Wang

et al. 2024

Oncol Rep

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IFNα-induced BST2+ tumor-associated macrophages facilitate immunosuppression and tumor growth in pancreatic cancer by ERK-CXCL7 signaling

Zheng,

Wang,

Zhou

et al. 2024

Cell Reports

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BST2 is an immune-related prognostic biomarker for glioma

Zhang

Ouyang

et al. 2023

Preprint

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Background Glioma is the most common brain cancer. Research has indicated that the tumor microenvironment (TME) plays an important role in the proliferation, invasion, and treatment response of tumors. However, the role of TME in glioma remains unclear. Here, we try to identify a TME-related gene in glioma that can predict prognosis. Methods The transcriptome data and corresponding clinical data of 701 glioma samples were downloaded from the TCGA database. The transcriptome data of normal samples were obtained from the Genotype-Tissue Expression (GTEx) database. R software and R packages were used to perform statistical analysis, calculation of TME scores, survival analysis, Cox regression analysis, and functional enrichment analyses. GSEA software was used to perform Gene Set Enrichment Analysis (GSEA). Protein-protein interaction (PPI) network analysis was performed using Cytoscape software. The protein expression level of BST2 was detected by immunohistochemistry. Results By gene differential expression analysis based on TME scores, we obtained two sets of differentially expressed genes (DEGs), respectively, followed by intersection analysis, we obtained shared DEGs. By univariate Cox regression analysis and PPI network analysis of the shared DEGs, we obtained a prognostic gene set and hub gene set, respectively, followed by intersection analysis, we obtained three hub genes associated with prognosis, including BST2, CCL2, and RSAD2. Subsequent analyses were focused on BST2. Compared with normal samples, BST2 expression was higher in glioma samples. Moreover, BST2 expression was positively correlated with pathological grades and was negatively correlated with overall survival time (OS). Consistently, a validation cohort of 42 glioma patients further verified the upregulation of BST2 and its influence on prognosis. Mechanistically, the result of GSEA indicated that BST2 might be involved in regulating tumor immunity. By differential analysis of tumor-infiltrating immune cells (TICs) contents between high- and low-BST2 expression groups, and correlation analyses between the expression level of BST2 and TICs contents, we obtained 7 key TICs, and 5 of them were significantly associated with OS, especially regulatory T cells and M2 macrophages. Conclusions The TME-related gene BST2 could promote the progression of glioma via regulating the composition of TICs, and thus might be a novel prognostic biomarker.

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Increased BST-2 expression by HBV infection promotes HBV-associated HCC tumorigenesis

Cited by 4 publications

References 48 publications

Bone marrow stromal cell antigen 2: Tumor biology, signaling pathway and therapeutic targeting (Review)

Bone marrow stromal cell antigen 2: Tumor biology, signaling pathway and therapeutic targeting (Review)

IFNα-induced BST2+ tumor-associated macrophages facilitate immunosuppression and tumor growth in pancreatic cancer by ERK-CXCL7 signaling

BST2 is an immune-related prognostic biomarker for glioma

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